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The geometric design of micromachined silicon sieve electrodes influences functional nerve regeneration

Wallman, Lars LU ; Zhang, Yuanyuan LU ; Laurell, Thomas LU and Danielsen, Nils LU (2001) In Biomaterials 22(10). p.1187-1193
Abstract
A neural interface could be used to control a limb prosthesis. Such an interface can be created by facilitating axonal regeneration through a sieve electrode and then register nerve signals intended to control the prosthesis. A key question is how to design the electrodes to ensure the best possible regeneration. Our previous studies have indicated that regeneration can be achieved using electrodes with square-shaped, 100×100 μm, via holes (holes that axons will regenerate through). Other reports have indicated a suitable range of these holes between 40 and 65 μm. In the present study we used silicon sieve electrodes with via holes of either 30 or 90 μm. The transparency, i.e. the percentage of the total via hole area, of these electrodes... (More)
A neural interface could be used to control a limb prosthesis. Such an interface can be created by facilitating axonal regeneration through a sieve electrode and then register nerve signals intended to control the prosthesis. A key question is how to design the electrodes to ensure the best possible regeneration. Our previous studies have indicated that regeneration can be achieved using electrodes with square-shaped, 100×100 μm, via holes (holes that axons will regenerate through). Other reports have indicated a suitable range of these holes between 40 and 65 μm. In the present study we used silicon sieve electrodes with via holes of either 30 or 90 μm. The transparency, i.e. the percentage of the total via hole area, of these electrodes was either 20 or 30%. The electrodes were inserted into a silicone chamber which was used to bridge a gap in a rat sciatic nerve. After 12 weeks of nerve regeneration electrodes with a hole size of 30 μm and a 30% transparency had the most favourable result as judged by the regained gastrocnemius muscle force and the formation of reactive tissue inside the chamber. The sieve electrode transparency is crucial for ensuring regeneration. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Silicon, Nerve regeneration, Rat sciatic nerve, Sieve electrode
in
Biomaterials
volume
22
issue
10
pages
1187 - 1193
publisher
Elsevier
external identifiers
  • wos:000168325100018
  • scopus:0035098603
ISSN
1878-5905
DOI
language
English
LU publication?
yes
id
b7abb802-cb8c-4511-b507-14b808ccbdb7 (old id 1121188)
date added to LUP
2008-07-17 10:51:10
date last changed
2018-06-03 03:42:29
@article{b7abb802-cb8c-4511-b507-14b808ccbdb7,
  abstract     = {A neural interface could be used to control a limb prosthesis. Such an interface can be created by facilitating axonal regeneration through a sieve electrode and then register nerve signals intended to control the prosthesis. A key question is how to design the electrodes to ensure the best possible regeneration. Our previous studies have indicated that regeneration can be achieved using electrodes with square-shaped, 100×100 μm, via holes (holes that axons will regenerate through). Other reports have indicated a suitable range of these holes between 40 and 65 μm. In the present study we used silicon sieve electrodes with via holes of either 30 or 90 μm. The transparency, i.e. the percentage of the total via hole area, of these electrodes was either 20 or 30%. The electrodes were inserted into a silicone chamber which was used to bridge a gap in a rat sciatic nerve. After 12 weeks of nerve regeneration electrodes with a hole size of 30 μm and a 30% transparency had the most favourable result as judged by the regained gastrocnemius muscle force and the formation of reactive tissue inside the chamber. The sieve electrode transparency is crucial for ensuring regeneration.},
  author       = {Wallman, Lars and Zhang, Yuanyuan and Laurell, Thomas and Danielsen, Nils},
  issn         = {1878-5905},
  keyword      = {Silicon,Nerve regeneration,Rat sciatic nerve,Sieve electrode},
  language     = {eng},
  number       = {10},
  pages        = {1187--1193},
  publisher    = {Elsevier},
  series       = {Biomaterials},
  title        = {The geometric design of micromachined silicon sieve electrodes influences functional nerve regeneration},
  url          = {http://dx.doi.org/},
  volume       = {22},
  year         = {2001},
}