Decline of C-peptide during the first year after diagnosis of Type 1 diabetes in children and adolescents
(2013) In Diabetes Research and Clinical Practice 100(2). p.203-209- Abstract
- Aims/hypothesis: We studied the decline of C-peptide during the first year after diagnosis of Type 1 diabetes (T1D), and its relation to various factors. Methods: 3824/4017 newly diagnosed patients (95%) were classified as T1D in a national study. In a non-selected subgroup of 1669 T1D patients we determined non-fasting C-peptide both at diagnosis and after 1 year, and analyzed decline in relation to clinical symptoms and signs, initial C-peptide and occurrence of auto-antibodies. Results: Younger children lost more C-peptide (p < 0.001) and the higher the C-peptide at diagnosis the larger the decline during the first year (p < 0.0000). Patients with higher BMI had higher C-peptide at diagnosis but lost more (p < 0.01), and those... (More)
- Aims/hypothesis: We studied the decline of C-peptide during the first year after diagnosis of Type 1 diabetes (T1D), and its relation to various factors. Methods: 3824/4017 newly diagnosed patients (95%) were classified as T1D in a national study. In a non-selected subgroup of 1669 T1D patients we determined non-fasting C-peptide both at diagnosis and after 1 year, and analyzed decline in relation to clinical symptoms and signs, initial C-peptide and occurrence of auto-antibodies. Results: Younger children lost more C-peptide (p < 0.001) and the higher the C-peptide at diagnosis the larger the decline during the first year (p < 0.0000). Patients with higher BMI had higher C-peptide at diagnosis but lost more (p < 0.01), and those with lower HbA1c, without symptoms and signs at diagnosis, and with higher BMI, had higher C-peptide at diagnosis, but lost more during the first year (p < 0.001). Finally, patients diagnosed during autumn had higher C-peptide at diagnosis, but lost more during the coming year (p < 0.001). Occurrence of auto-antibodies did not correlate with C-peptide decline, except possibly for a more rapid loss in IAA-positive patients. Conclusions/interpretation: Even in a restricted geographical area and narrow age range (< 18 years), the natural course of Type 1 diabetes is heterogeneous. This should be considered in clinical trials. (C) 2013 Elsevier Ireland Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3979227
- author
- Ludvigsson, Johnny ; Carlsson, Annelie LU ; Deli, Ahmed ; Forsander, Gun ; Ivarsson, Sten LU ; Kockum, Ingrid ; Lindblad, Bengt LU ; Marcus, Claude ; Lernmark, Ake LU and Samuelsson, Ulf
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- C-peptide, Natural course, Type 1 diabetes, Children, BMI, Intervention, trials
- in
- Diabetes Research and Clinical Practice
- volume
- 100
- issue
- 2
- pages
- 203 - 209
- publisher
- Elsevier
- external identifiers
-
- wos:000320590900016
- scopus:84878376574
- pmid:23529064
- ISSN
- 1872-8227
- DOI
- 10.1016/j.diabres.2013.03.003
- project
- Better Diabetes Diagnosis (BDD)
- language
- English
- LU publication?
- yes
- id
- b9eb6ff1-a724-4721-8528-8a029091ee60 (old id 3979227)
- date added to LUP
- 2016-04-01 09:57:45
- date last changed
- 2023-01-01 23:53:08
@article{b9eb6ff1-a724-4721-8528-8a029091ee60, abstract = {{Aims/hypothesis: We studied the decline of C-peptide during the first year after diagnosis of Type 1 diabetes (T1D), and its relation to various factors. Methods: 3824/4017 newly diagnosed patients (95%) were classified as T1D in a national study. In a non-selected subgroup of 1669 T1D patients we determined non-fasting C-peptide both at diagnosis and after 1 year, and analyzed decline in relation to clinical symptoms and signs, initial C-peptide and occurrence of auto-antibodies. Results: Younger children lost more C-peptide (p < 0.001) and the higher the C-peptide at diagnosis the larger the decline during the first year (p < 0.0000). Patients with higher BMI had higher C-peptide at diagnosis but lost more (p < 0.01), and those with lower HbA1c, without symptoms and signs at diagnosis, and with higher BMI, had higher C-peptide at diagnosis, but lost more during the first year (p < 0.001). Finally, patients diagnosed during autumn had higher C-peptide at diagnosis, but lost more during the coming year (p < 0.001). Occurrence of auto-antibodies did not correlate with C-peptide decline, except possibly for a more rapid loss in IAA-positive patients. Conclusions/interpretation: Even in a restricted geographical area and narrow age range (< 18 years), the natural course of Type 1 diabetes is heterogeneous. This should be considered in clinical trials. (C) 2013 Elsevier Ireland Ltd. All rights reserved.}}, author = {{Ludvigsson, Johnny and Carlsson, Annelie and Deli, Ahmed and Forsander, Gun and Ivarsson, Sten and Kockum, Ingrid and Lindblad, Bengt and Marcus, Claude and Lernmark, Ake and Samuelsson, Ulf}}, issn = {{1872-8227}}, keywords = {{C-peptide; Natural course; Type 1 diabetes; Children; BMI; Intervention; trials}}, language = {{eng}}, number = {{2}}, pages = {{203--209}}, publisher = {{Elsevier}}, series = {{Diabetes Research and Clinical Practice}}, title = {{Decline of C-peptide during the first year after diagnosis of Type 1 diabetes in children and adolescents}}, url = {{http://dx.doi.org/10.1016/j.diabres.2013.03.003}}, doi = {{10.1016/j.diabres.2013.03.003}}, volume = {{100}}, year = {{2013}}, }