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Thrombin generation assays (TGAs)

Salvagno, Gian Luca LU and Berntorp, Erik LU (2017) In Methods in Molecular Biology 1646. p.515-522
Abstract

In recent years, there has been a revival of interest in a time-honored tool of the clotting trade: the thrombin generation curve or thrombin generation (TG) assay (TGA) as we now call it. Thrombin generation is a key coagulation process that determines the extent of a hemostatic plug or a thrombotic process. The recent development of newer tests based on the continuous registration of TG under in vitro conditions that mimic more closely what occurs in vivo prompted us to reinvestigate the balance between procoagulants and anticoagulants in patients. Measurement of TG is accepted as a research tool, but the variety of sources and concentrations of reagents, as well as technical constraints, limit its potential for proper clinical use.... (More)

In recent years, there has been a revival of interest in a time-honored tool of the clotting trade: the thrombin generation curve or thrombin generation (TG) assay (TGA) as we now call it. Thrombin generation is a key coagulation process that determines the extent of a hemostatic plug or a thrombotic process. The recent development of newer tests based on the continuous registration of TG under in vitro conditions that mimic more closely what occurs in vivo prompted us to reinvestigate the balance between procoagulants and anticoagulants in patients. Measurement of TG is accepted as a research tool, but the variety of sources and concentrations of reagents, as well as technical constraints, limit its potential for proper clinical use. The newer TGAs not only provide an overall assessment of hemostasis but also provide promising laboratory tools for investigating hemorrhagic coagulopathies and monitoring replacement therapy in several clinical conditions.

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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Coagulation, Hemophilia, Thrombin generation assay
in
Methods in Molecular Biology
volume
1646
pages
8 pages
publisher
Humana Press
external identifiers
  • scopus:85027506642
ISSN
10643745
DOI
10.1007/978-1-4939-7196-1_37
language
English
LU publication?
yes
id
ba24400a-7f4a-4b24-a2f2-b02e33533771
date added to LUP
2017-09-14 13:45:22
date last changed
2017-09-15 03:00:03
@inbook{ba24400a-7f4a-4b24-a2f2-b02e33533771,
  abstract     = {<p>In recent years, there has been a revival of interest in a time-honored tool of the clotting trade: the thrombin generation curve or thrombin generation (TG) assay (TGA) as we now call it. Thrombin generation is a key coagulation process that determines the extent of a hemostatic plug or a thrombotic process. The recent development of newer tests based on the continuous registration of TG under in vitro conditions that mimic more closely what occurs in vivo prompted us to reinvestigate the balance between procoagulants and anticoagulants in patients. Measurement of TG is accepted as a research tool, but the variety of sources and concentrations of reagents, as well as technical constraints, limit its potential for proper clinical use. The newer TGAs not only provide an overall assessment of hemostasis but also provide promising laboratory tools for investigating hemorrhagic coagulopathies and monitoring replacement therapy in several clinical conditions.</p>},
  author       = {Salvagno, Gian Luca and Berntorp, Erik},
  issn         = {10643745},
  keyword      = {Coagulation,Hemophilia,Thrombin generation assay},
  language     = {eng},
  pages        = {515--522},
  publisher    = {Humana Press},
  series       = {Methods in Molecular Biology},
  title        = {Thrombin generation assays (TGAs)},
  url          = {http://dx.doi.org/10.1007/978-1-4939-7196-1_37},
  volume       = {1646},
  year         = {2017},
}