Thrombin generation assays (TGAs)
(2017) In Methods in Molecular Biology 1646. p.515-522- Abstract
In recent years, there has been a revival of interest in a time-honored tool of the clotting trade: the thrombin generation curve or thrombin generation (TG) assay (TGA) as we now call it. Thrombin generation is a key coagulation process that determines the extent of a hemostatic plug or a thrombotic process. The recent development of newer tests based on the continuous registration of TG under in vitro conditions that mimic more closely what occurs in vivo prompted us to reinvestigate the balance between procoagulants and anticoagulants in patients. Measurement of TG is accepted as a research tool, but the variety of sources and concentrations of reagents, as well as technical constraints, limit its potential for proper clinical use.... (More)
In recent years, there has been a revival of interest in a time-honored tool of the clotting trade: the thrombin generation curve or thrombin generation (TG) assay (TGA) as we now call it. Thrombin generation is a key coagulation process that determines the extent of a hemostatic plug or a thrombotic process. The recent development of newer tests based on the continuous registration of TG under in vitro conditions that mimic more closely what occurs in vivo prompted us to reinvestigate the balance between procoagulants and anticoagulants in patients. Measurement of TG is accepted as a research tool, but the variety of sources and concentrations of reagents, as well as technical constraints, limit its potential for proper clinical use. The newer TGAs not only provide an overall assessment of hemostasis but also provide promising laboratory tools for investigating hemorrhagic coagulopathies and monitoring replacement therapy in several clinical conditions.
(Less)
- author
- Salvagno, Gian Luca LU and Berntorp, Erik LU
- organization
- publishing date
- 2017
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Coagulation, Hemophilia, Thrombin generation assay
- host publication
- Methods in Molecular Biology
- series title
- Methods in Molecular Biology
- volume
- 1646
- pages
- 8 pages
- publisher
- Humana Press
- external identifiers
-
- scopus:85027506642
- pmid:28804851
- ISSN
- 10643745
- DOI
- 10.1007/978-1-4939-7196-1_37
- language
- English
- LU publication?
- yes
- id
- ba24400a-7f4a-4b24-a2f2-b02e33533771
- date added to LUP
- 2017-09-14 13:45:22
- date last changed
- 2024-03-31 16:45:19
@inbook{ba24400a-7f4a-4b24-a2f2-b02e33533771,
abstract = {{<p>In recent years, there has been a revival of interest in a time-honored tool of the clotting trade: the thrombin generation curve or thrombin generation (TG) assay (TGA) as we now call it. Thrombin generation is a key coagulation process that determines the extent of a hemostatic plug or a thrombotic process. The recent development of newer tests based on the continuous registration of TG under in vitro conditions that mimic more closely what occurs in vivo prompted us to reinvestigate the balance between procoagulants and anticoagulants in patients. Measurement of TG is accepted as a research tool, but the variety of sources and concentrations of reagents, as well as technical constraints, limit its potential for proper clinical use. The newer TGAs not only provide an overall assessment of hemostasis but also provide promising laboratory tools for investigating hemorrhagic coagulopathies and monitoring replacement therapy in several clinical conditions.</p>}},
author = {{Salvagno, Gian Luca and Berntorp, Erik}},
booktitle = {{Methods in Molecular Biology}},
issn = {{10643745}},
keywords = {{Coagulation; Hemophilia; Thrombin generation assay}},
language = {{eng}},
pages = {{515--522}},
publisher = {{Humana Press}},
series = {{Methods in Molecular Biology}},
title = {{Thrombin generation assays (TGAs)}},
url = {{http://dx.doi.org/10.1007/978-1-4939-7196-1_37}},
doi = {{10.1007/978-1-4939-7196-1_37}},
volume = {{1646}},
year = {{2017}},
}