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Role of Mannose-binding Lectin and Association with Microbial Sensitization in a Cohort of Patients with Atopic Dermatitis

Belfrage, Emma LU ; Jinnestål, Camilla L ; Jönsen, Andreas LU ; Bengtsson, Anders LU ; Åkesson, Anna ; Schmidtchen, Artur LU and Sonesson, Andreas LU (2023) In Acta Dermato-Venereologica 103. p.1-5
Abstract

Atopic dermatitis is a relapsing inflammatory skin condition, in which bacteria, fungi and viruses may colonize the skin and aggravate the condition. Mannose-binding lectin is part of the innate immune system. Polymorphism in the mannose-binding lectin gene can result in deficiency of mannose-binding lectin, which may affect defence against microbes. The aim of this study was to investigate whether polymorphisms in the mannose-binding lectin gene affect the extent of sensitization to common skin microbes, the skin barrier function, or the severity of the disease in a cohort of patients with atopic dermatitis. Genetic testing of mannose-binding lectin polymorphism was performed in 60 patients with atopic dermatitis. The disease severity,... (More)

Atopic dermatitis is a relapsing inflammatory skin condition, in which bacteria, fungi and viruses may colonize the skin and aggravate the condition. Mannose-binding lectin is part of the innate immune system. Polymorphism in the mannose-binding lectin gene can result in deficiency of mannose-binding lectin, which may affect defence against microbes. The aim of this study was to investigate whether polymorphisms in the mannose-binding lectin gene affect the extent of sensitization to common skin microbes, the skin barrier function, or the severity of the disease in a cohort of patients with atopic dermatitis. Genetic testing of mannose-binding lectin polymorphism was performed in 60 patients with atopic dermatitis. The disease severity, skin barrier function, and serum levels of specific immunoglobulin E against skin microbes were measured. In patients with low mannose-binding lectin genotype (group 1) 6 of 8 (75%) were sensitized to Candida albicans, compared to 14 of 22 (63.6%) patients with intermediate mannose-binding genotype (group 2) and 10 of 30 (33.3%) patients with high mannose-binding genotype (group 3). Group 1 (low mannose-binding lectin) was more likely to be sensitized to Candida albicans compared with group 3 (high mannose-binding lectin) (odds ratio 6.34, p-value 0.045). In this cohort of patients with atopic dermatitis, mannose-binding lectin deficiency was associated with increased sensitization to Candida albicans.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Dermatitis, Atopic/diagnosis, Genotype, Mannose, Mannose-Binding Lectin/genetics, Polymorphism, Genetic, Skin
in
Acta Dermato-Venereologica
volume
103
article number
adv2405
pages
1 - 5
publisher
Medical Journals Limited
external identifiers
  • pmid:36994777
  • scopus:85151228805
ISSN
1651-2057
DOI
10.2340/actadv.v103.2405
language
English
LU publication?
yes
id
ba96f647-1b36-41ee-ae08-7dd3310fcc1e
date added to LUP
2023-04-24 12:52:21
date last changed
2025-03-09 03:48:10
@article{ba96f647-1b36-41ee-ae08-7dd3310fcc1e,
  abstract     = {{<p>Atopic dermatitis is a relapsing inflammatory skin condition, in which bacteria, fungi and viruses may colonize the skin and aggravate the condition. Mannose-binding lectin is part of the innate immune system. Polymorphism in the mannose-binding lectin gene can result in deficiency of mannose-binding lectin, which may affect defence against microbes. The aim of this study was to investigate whether polymorphisms in the mannose-binding lectin gene affect the extent of sensitization to common skin microbes, the skin barrier function, or the severity of the disease in a cohort of patients with atopic dermatitis. Genetic testing of mannose-binding lectin polymorphism was performed in 60 patients with atopic dermatitis. The disease severity, skin barrier function, and serum levels of specific immunoglobulin E against skin microbes were measured. In patients with low mannose-binding lectin genotype (group 1) 6 of 8 (75%) were sensitized to Candida albicans, compared to 14 of 22 (63.6%) patients with intermediate mannose-binding genotype (group 2) and 10 of 30 (33.3%) patients with high mannose-binding genotype (group 3). Group 1 (low mannose-binding lectin) was more likely to be sensitized to Candida albicans compared with group 3 (high mannose-binding lectin) (odds ratio 6.34, p-value 0.045). In this cohort of patients with atopic dermatitis, mannose-binding lectin deficiency was associated with increased sensitization to Candida albicans.</p>}},
  author       = {{Belfrage, Emma and Jinnestål, Camilla L and Jönsen, Andreas and Bengtsson, Anders and Åkesson, Anna and Schmidtchen, Artur and Sonesson, Andreas}},
  issn         = {{1651-2057}},
  keywords     = {{Humans; Dermatitis, Atopic/diagnosis; Genotype; Mannose; Mannose-Binding Lectin/genetics; Polymorphism, Genetic; Skin}},
  language     = {{eng}},
  pages        = {{1--5}},
  publisher    = {{Medical Journals Limited}},
  series       = {{Acta Dermato-Venereologica}},
  title        = {{Role of Mannose-binding Lectin and Association with Microbial Sensitization in a Cohort of Patients with Atopic Dermatitis}},
  url          = {{http://dx.doi.org/10.2340/actadv.v103.2405}},
  doi          = {{10.2340/actadv.v103.2405}},
  volume       = {{103}},
  year         = {{2023}},
}