The small-for-gestational-age fetus has an intact ability to develop lacticemia when exposed to hypoxia : a retrospective comparative register study
(2018) In Journal of Maternal-Fetal and Neonatal Medicine 31(10). p.1290-1297- Abstract
Objective: To investigate the ability of small-for-gestational-age (SGA) fetuses to develop lacticemia during hypoxia. Methods: Umbilical cord arterial and venous pH, lactate and glucose concentrations were determined in 1777 SGA (<10th percentile) and 14,569 AGA newborns and related to acidemia (pH < mean –2SD). Non-parametric statistics with two-sided p < .05 were considered significant. Results: Glucose and lactate were linearly related and both variables correlated negatively with pH. Glucose was equal in SGA and AGA at a normal pH, but at severe acidemia it was lower in SGA. Glucose was higher in both groups during acidemia. Lactate was higher in SGA at both a normal and a low pH, and in both groups lactate increased... (More)
Objective: To investigate the ability of small-for-gestational-age (SGA) fetuses to develop lacticemia during hypoxia. Methods: Umbilical cord arterial and venous pH, lactate and glucose concentrations were determined in 1777 SGA (<10th percentile) and 14,569 AGA newborns and related to acidemia (pH < mean –2SD). Non-parametric statistics with two-sided p < .05 were considered significant. Results: Glucose and lactate were linearly related and both variables correlated negatively with pH. Glucose was equal in SGA and AGA at a normal pH, but at severe acidemia it was lower in SGA. Glucose was higher in both groups during acidemia. Lactate was higher in SGA at both a normal and a low pH, and in both groups lactate increased progressively with the severity of acidemia. Conclusions: In both SGA and AGA fetuses, glucose was mobilized during acidemia; lactate was higher in SGA at both a normal and low pH. Considering SGA being a proxy for fetal growth restriction, and acidemia a proxy for hypoxia, it is concluded that growth-restricted fetuses have an intact ability to develop lacticemia during hypoxia.
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- author
- Åkerman, Fernanda ; Mokarami, Parisa LU ; Källén, Karin LU and Olofsson, Per LU
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cord blood, glucose, growth restriction, hypoxia, IUGR, lactate, SGA
- in
- Journal of Maternal-Fetal and Neonatal Medicine
- volume
- 31
- issue
- 10
- pages
- 1290 - 1297
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:85018827853
- pmid:28372508
- ISSN
- 1476-7058
- DOI
- 10.1080/14767058.2017.1315098
- language
- English
- LU publication?
- yes
- id
- baade514-a705-4498-97c7-168a08d19087
- date added to LUP
- 2017-06-08 14:29:11
- date last changed
- 2024-07-07 19:23:23
@article{baade514-a705-4498-97c7-168a08d19087, abstract = {{<p>Objective: To investigate the ability of small-for-gestational-age (SGA) fetuses to develop lacticemia during hypoxia. Methods: Umbilical cord arterial and venous pH, lactate and glucose concentrations were determined in 1777 SGA (<10th percentile) and 14,569 AGA newborns and related to acidemia (pH < mean –2SD). Non-parametric statistics with two-sided p < .05 were considered significant. Results: Glucose and lactate were linearly related and both variables correlated negatively with pH. Glucose was equal in SGA and AGA at a normal pH, but at severe acidemia it was lower in SGA. Glucose was higher in both groups during acidemia. Lactate was higher in SGA at both a normal and a low pH, and in both groups lactate increased progressively with the severity of acidemia. Conclusions: In both SGA and AGA fetuses, glucose was mobilized during acidemia; lactate was higher in SGA at both a normal and low pH. Considering SGA being a proxy for fetal growth restriction, and acidemia a proxy for hypoxia, it is concluded that growth-restricted fetuses have an intact ability to develop lacticemia during hypoxia.</p>}}, author = {{Åkerman, Fernanda and Mokarami, Parisa and Källén, Karin and Olofsson, Per}}, issn = {{1476-7058}}, keywords = {{Cord blood; glucose; growth restriction; hypoxia; IUGR; lactate; SGA}}, language = {{eng}}, number = {{10}}, pages = {{1290--1297}}, publisher = {{Taylor & Francis}}, series = {{Journal of Maternal-Fetal and Neonatal Medicine}}, title = {{The small-for-gestational-age fetus has an intact ability to develop lacticemia when exposed to hypoxia : a retrospective comparative register study}}, url = {{http://dx.doi.org/10.1080/14767058.2017.1315098}}, doi = {{10.1080/14767058.2017.1315098}}, volume = {{31}}, year = {{2018}}, }