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The small-for-gestational-age fetus has an intact ability to develop lacticemia when exposed to hypoxia : a retrospective comparative register study

Åkerman, Fernanda ; Mokarami, Parisa LU ; Källén, Karin LU and Olofsson, Per LU (2018) In Journal of Maternal-Fetal and Neonatal Medicine 31(10). p.1290-1297
Abstract

Objective: To investigate the ability of small-for-gestational-age (SGA) fetuses to develop lacticemia during hypoxia. Methods: Umbilical cord arterial and venous pH, lactate and glucose concentrations were determined in 1777 SGA (<10th percentile) and 14,569 AGA newborns and related to acidemia (pH < mean –2SD). Non-parametric statistics with two-sided p < .05 were considered significant. Results: Glucose and lactate were linearly related and both variables correlated negatively with pH. Glucose was equal in SGA and AGA at a normal pH, but at severe acidemia it was lower in SGA. Glucose was higher in both groups during acidemia. Lactate was higher in SGA at both a normal and a low pH, and in both groups lactate increased... (More)

Objective: To investigate the ability of small-for-gestational-age (SGA) fetuses to develop lacticemia during hypoxia. Methods: Umbilical cord arterial and venous pH, lactate and glucose concentrations were determined in 1777 SGA (<10th percentile) and 14,569 AGA newborns and related to acidemia (pH < mean –2SD). Non-parametric statistics with two-sided p < .05 were considered significant. Results: Glucose and lactate were linearly related and both variables correlated negatively with pH. Glucose was equal in SGA and AGA at a normal pH, but at severe acidemia it was lower in SGA. Glucose was higher in both groups during acidemia. Lactate was higher in SGA at both a normal and a low pH, and in both groups lactate increased progressively with the severity of acidemia. Conclusions: In both SGA and AGA fetuses, glucose was mobilized during acidemia; lactate was higher in SGA at both a normal and low pH. Considering SGA being a proxy for fetal growth restriction, and acidemia a proxy for hypoxia, it is concluded that growth-restricted fetuses have an intact ability to develop lacticemia during hypoxia.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cord blood, glucose, growth restriction, hypoxia, IUGR, lactate, SGA
in
Journal of Maternal-Fetal and Neonatal Medicine
volume
31
issue
10
pages
1290 - 1297
publisher
Taylor & Francis
external identifiers
  • pmid:28372508
  • scopus:85018827853
ISSN
1476-7058
DOI
10.1080/14767058.2017.1315098
language
English
LU publication?
yes
id
baade514-a705-4498-97c7-168a08d19087
date added to LUP
2017-06-08 14:29:11
date last changed
2022-03-24 19:03:09
@article{baade514-a705-4498-97c7-168a08d19087,
  abstract     = {{<p>Objective: To investigate the ability of small-for-gestational-age (SGA) fetuses to develop lacticemia during hypoxia. Methods: Umbilical cord arterial and venous pH, lactate and glucose concentrations were determined in 1777 SGA (&lt;10th percentile) and 14,569 AGA newborns and related to acidemia (pH &lt; mean –2SD). Non-parametric statistics with two-sided p &lt; .05 were considered significant. Results: Glucose and lactate were linearly related and both variables correlated negatively with pH. Glucose was equal in SGA and AGA at a normal pH, but at severe acidemia it was lower in SGA. Glucose was higher in both groups during acidemia. Lactate was higher in SGA at both a normal and a low pH, and in both groups lactate increased progressively with the severity of acidemia. Conclusions: In both SGA and AGA fetuses, glucose was mobilized during acidemia; lactate was higher in SGA at both a normal and low pH. Considering SGA being a proxy for fetal growth restriction, and acidemia a proxy for hypoxia, it is concluded that growth-restricted fetuses have an intact ability to develop lacticemia during hypoxia.</p>}},
  author       = {{Åkerman, Fernanda and Mokarami, Parisa and Källén, Karin and Olofsson, Per}},
  issn         = {{1476-7058}},
  keywords     = {{Cord blood; glucose; growth restriction; hypoxia; IUGR; lactate; SGA}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1290--1297}},
  publisher    = {{Taylor & Francis}},
  series       = {{Journal of Maternal-Fetal and Neonatal Medicine}},
  title        = {{The small-for-gestational-age fetus has an intact ability to develop lacticemia when exposed to hypoxia : a retrospective comparative register study}},
  url          = {{http://dx.doi.org/10.1080/14767058.2017.1315098}},
  doi          = {{10.1080/14767058.2017.1315098}},
  volume       = {{31}},
  year         = {{2018}},
}