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Polyamines and microbiota in bicuspid and tricuspid aortic valve aortopathy

Forte, Amalia; Balistreri, Carmela Rita; De Feo, Marisa; Della Corte, Alessandro; Hellstrand, Per LU ; Persson, Lo LU and Nilsson, Bengt Olof LU (2019) In Journal of Molecular and Cellular Cardiology 129. p.179-187
Abstract

Polyamines are small aliphatic cationic molecules synthesized via a highly regulated pathway and involved in general molecular and cellular phenomena. Both mammalian cells and microorganisms synthesize polyamines, and both sources may contribute to the presence of polyamines in the circulation. The dominant location for microorganisms within the body is the gut. Accordingly, the gut microbiota probably synthesizes most of the polyamines in the circulation in addition to those produced by the mammalian host cells. Polyamines are mandatory for cellular growth and proliferation. Established evidence suggests that the polyamine spermidine prolongs lifespan and improves cardiovascular health in animal models and humans through both local... (More)

Polyamines are small aliphatic cationic molecules synthesized via a highly regulated pathway and involved in general molecular and cellular phenomena. Both mammalian cells and microorganisms synthesize polyamines, and both sources may contribute to the presence of polyamines in the circulation. The dominant location for microorganisms within the body is the gut. Accordingly, the gut microbiota probably synthesizes most of the polyamines in the circulation in addition to those produced by the mammalian host cells. Polyamines are mandatory for cellular growth and proliferation. Established evidence suggests that the polyamine spermidine prolongs lifespan and improves cardiovascular health in animal models and humans through both local mechanisms, involving improved cardiomyocyte function, and systemic mechanisms, including increased NO bioavailability and reduced systemic inflammation. Higher levels of polyamines have been detected in non-dilated aorta of patients affected by bicuspid aortic valve congenital malformation, an aortopathy associated with an increased risk for thoracic ascending aorta aneurysm. In this review, we discuss metabolism of polyamines and their potential effects on vascular smooth muscle and endothelial cell function in vascular pathology of the thoracic ascending aorta associated with bicuspid or tricuspid aortic valve.

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author
organization
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type
Contribution to journal
publication status
published
subject
in
Journal of Molecular and Cellular Cardiology
volume
129
pages
9 pages
publisher
Elsevier
external identifiers
  • scopus:85062403750
ISSN
0022-2828
DOI
10.1016/j.yjmcc.2019.02.014
language
English
LU publication?
yes
id
baf47c22-57f0-4d04-aef1-1654906bba61
date added to LUP
2019-03-12 12:38:50
date last changed
2019-04-10 04:20:49
@article{baf47c22-57f0-4d04-aef1-1654906bba61,
  abstract     = {<p>Polyamines are small aliphatic cationic molecules synthesized via a highly regulated pathway and involved in general molecular and cellular phenomena. Both mammalian cells and microorganisms synthesize polyamines, and both sources may contribute to the presence of polyamines in the circulation. The dominant location for microorganisms within the body is the gut. Accordingly, the gut microbiota probably synthesizes most of the polyamines in the circulation in addition to those produced by the mammalian host cells. Polyamines are mandatory for cellular growth and proliferation. Established evidence suggests that the polyamine spermidine prolongs lifespan and improves cardiovascular health in animal models and humans through both local mechanisms, involving improved cardiomyocyte function, and systemic mechanisms, including increased NO bioavailability and reduced systemic inflammation. Higher levels of polyamines have been detected in non-dilated aorta of patients affected by bicuspid aortic valve congenital malformation, an aortopathy associated with an increased risk for thoracic ascending aorta aneurysm. In this review, we discuss metabolism of polyamines and their potential effects on vascular smooth muscle and endothelial cell function in vascular pathology of the thoracic ascending aorta associated with bicuspid or tricuspid aortic valve.</p>},
  author       = {Forte, Amalia and Balistreri, Carmela Rita and De Feo, Marisa and Della Corte, Alessandro and Hellstrand, Per and Persson, Lo and Nilsson, Bengt Olof},
  issn         = {0022-2828},
  language     = {eng},
  pages        = {179--187},
  publisher    = {Elsevier},
  series       = {Journal of Molecular and Cellular Cardiology},
  title        = {Polyamines and microbiota in bicuspid and tricuspid aortic valve aortopathy},
  url          = {http://dx.doi.org/10.1016/j.yjmcc.2019.02.014},
  volume       = {129},
  year         = {2019},
}