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Interstitial laser thermotherapy of a rat liver adenocarcinoma

Tranberg, K G LU ; Myllymäki, L ; Möller, P H LU ; Ivarsson, K LU ; Sjögren, H O LU and Stenram, U LU (2002) In Journal of X-Ray Science and Technology 10(3). p.177-185
Abstract

The aim of this study was to compare interstitial laser thermotherapy with excision of a liver tumour. A dimethylhydrazine-induced adenocarcinoma was implanted into the left lateral lobe of the rat liver, and treatment was performed 8 days later. Rats were treated with resection of the tumour-bearing lobe or underwent interstitial laser thermotherapy, which was performed at a steady-state temperature of 46°C for 30 min, 3 mm from the tumour margin. The incidence and extent of intraperitoneal spread was smaller after laser thermotherapy than after resection, with no difference in local control. Using inoculation of tumour cell suspensions into the lateral and the median lobes of the liver simultaneously and treating the lateral lobe... (More)

The aim of this study was to compare interstitial laser thermotherapy with excision of a liver tumour. A dimethylhydrazine-induced adenocarcinoma was implanted into the left lateral lobe of the rat liver, and treatment was performed 8 days later. Rats were treated with resection of the tumour-bearing lobe or underwent interstitial laser thermotherapy, which was performed at a steady-state temperature of 46°C for 30 min, 3 mm from the tumour margin. The incidence and extent of intraperitoneal spread was smaller after laser thermotherapy than after resection, with no difference in local control. Using inoculation of tumour cell suspensions into the lateral and the median lobes of the liver simultaneously and treating the lateral lobe tumour only, we found that laser thermotherapy reduced take and growth of the untreated tumour in the median lobe indicating that laser thermotherapy may induce immunologic effects. It is concluded that interstitial laser thermotherapy reduces spread of liver tumour as compared to resection. It is suggested that this can be at least partly explained by a laser-induced immunologic effect.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of X-Ray Science and Technology
volume
10
issue
3
pages
177 - 185
publisher
IOS Press
external identifiers
  • pmid:22388047
ISSN
0895-3996
language
English
LU publication?
yes
id
bbe31675-9a9c-4cef-bdaf-ab493ea0b297
alternative location
https://content.iospress.com/articles/journal-of-x-ray-science-and-technology/xst00067?resultNumber=0&totalResults=87&start=0&q=Interstitial+laser+thermotherapy+of+a+rat+liver+adenocarcinoma.&resultsPageSize=10&rows=10
date added to LUP
2019-06-15 17:28:15
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2020-12-13 04:11:55
@article{bbe31675-9a9c-4cef-bdaf-ab493ea0b297,
  abstract     = {<p>The aim of this study was to compare interstitial laser thermotherapy with excision of a liver tumour. A dimethylhydrazine-induced adenocarcinoma was implanted into the left lateral lobe of the rat liver, and treatment was performed 8 days later. Rats were treated with resection of the tumour-bearing lobe or underwent interstitial laser thermotherapy, which was performed at a steady-state temperature of 46°C for 30 min, 3 mm from the tumour margin. The incidence and extent of intraperitoneal spread was smaller after laser thermotherapy than after resection, with no difference in local control. Using inoculation of tumour cell suspensions into the lateral and the median lobes of the liver simultaneously and treating the lateral lobe tumour only, we found that laser thermotherapy reduced take and growth of the untreated tumour in the median lobe indicating that laser thermotherapy may induce immunologic effects. It is concluded that interstitial laser thermotherapy reduces spread of liver tumour as compared to resection. It is suggested that this can be at least partly explained by a laser-induced immunologic effect.</p>},
  author       = {Tranberg, K G and Myllymäki, L and Möller, P H and Ivarsson, K and Sjögren, H O and Stenram, U},
  issn         = {0895-3996},
  language     = {eng},
  month        = {01},
  number       = {3},
  pages        = {177--185},
  publisher    = {IOS Press},
  series       = {Journal of X-Ray Science and Technology},
  title        = {Interstitial laser thermotherapy of a rat liver adenocarcinoma},
  url          = {https://content.iospress.com/articles/journal-of-x-ray-science-and-technology/xst00067?resultNumber=0&totalResults=87&start=0&q=Interstitial+laser+thermotherapy+of+a+rat+liver+adenocarcinoma.&resultsPageSize=10&rows=10},
  volume       = {10},
  year         = {2002},
}