Changes in T-Peak-to-T-End Morphology Measured by Time-Warping are Associated with Ischemia-Induced Ventricular Fibrillation in a Porcine Model
(2023) 50th Computing in Cardiology, CinC 2023 In Computing in Cardiology- Abstract
In this work, we use a time-warping-based morphology variation index, d_{w}, computed between the peak and the end of the T-wave, and assess its association with the occurrence of ventricular fibrillation (VF) episodes in ischemic conditions. ECG recordings from 26 pigs under-going a 40-minute coronary occlusion were analyzed. The d_{w} series was obtained by quantifying the morphological differences between the final part of the T wave at different stages of the occlusion and a reference T wave in the control recording. During control recordings, d_{w} remained stationary with a median value along each recording of 1.76 ms, IQR of 1.80, while during artery occlusion followed a well-marked gradual increasing trend as ischemia... (More)
In this work, we use a time-warping-based morphology variation index, d_{w}, computed between the peak and the end of the T-wave, and assess its association with the occurrence of ventricular fibrillation (VF) episodes in ischemic conditions. ECG recordings from 26 pigs under-going a 40-minute coronary occlusion were analyzed. The d_{w} series was obtained by quantifying the morphological differences between the final part of the T wave at different stages of the occlusion and a reference T wave in the control recording. During control recordings, d_{w} remained stationary with a median value along each recording of 1.76 ms, IQR of 1.80, while during artery occlusion followed a well-marked gradual increasing trend as ischemia progressed, with median of 15.47 ms, IQR of 18.53. At the 20-to-25 min period from occlusion onset (and during 5 min prior to VF episode) dw averages in the VF group was significantly higher than in the non-VF group with median values of 40.0 (and 34.4) vs 7.8 (and 7.7) ms, with p-values of 0.002 (and 0.001), respectively. In conclusion, dynamic increases of the d_{w} index during ischaemia progression in pigs are associated with VF occurrence.
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- author
- Gomez, Neurys ; Ramirez, Julia ; Martin-Yebra, Alba ; Demidova, Marina M. LU ; Platonov, Pyotr LU ; Martinez, Juan Pablo and Laguna, Pablo
- organization
- publishing date
- 2023
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- Computing in Cardiology, CinC 2023
- series title
- Computing in Cardiology
- publisher
- IEEE Computer Society
- conference name
- 50th Computing in Cardiology, CinC 2023
- conference location
- Atlanta, United States
- conference dates
- 2023-10-01 - 2023-10-04
- external identifiers
-
- scopus:85182341798
- ISSN
- 2325-887X
- 2325-8861
- ISBN
- 9798350382525
- DOI
- 10.22489/CinC.2023.408
- language
- English
- LU publication?
- yes
- id
- bc940901-b228-4df2-bcd3-a16097ecccbc
- date added to LUP
- 2024-02-16 14:40:16
- date last changed
- 2024-04-17 08:24:56
@inproceedings{bc940901-b228-4df2-bcd3-a16097ecccbc,
abstract = {{<p>In this work, we use a time-warping-based morphology variation index, d_{w}, computed between the peak and the end of the T-wave, and assess its association with the occurrence of ventricular fibrillation (VF) episodes in ischemic conditions. ECG recordings from 26 pigs under-going a 40-minute coronary occlusion were analyzed. The d_{w} series was obtained by quantifying the morphological differences between the final part of the T wave at different stages of the occlusion and a reference T wave in the control recording. During control recordings, d_{w} remained stationary with a median value along each recording of 1.76 ms, IQR of 1.80, while during artery occlusion followed a well-marked gradual increasing trend as ischemia progressed, with median of 15.47 ms, IQR of 18.53. At the 20-to-25 min period from occlusion onset (and during 5 min prior to VF episode) dw averages in the VF group was significantly higher than in the non-VF group with median values of 40.0 (and 34.4) vs 7.8 (and 7.7) ms, with p-values of 0.002 (and 0.001), respectively. In conclusion, dynamic increases of the d_{w} index during ischaemia progression in pigs are associated with VF occurrence.</p>}},
author = {{Gomez, Neurys and Ramirez, Julia and Martin-Yebra, Alba and Demidova, Marina M. and Platonov, Pyotr and Martinez, Juan Pablo and Laguna, Pablo}},
booktitle = {{Computing in Cardiology, CinC 2023}},
isbn = {{9798350382525}},
issn = {{2325-887X}},
language = {{eng}},
publisher = {{IEEE Computer Society}},
series = {{Computing in Cardiology}},
title = {{Changes in T-Peak-to-T-End Morphology Measured by Time-Warping are Associated with Ischemia-Induced Ventricular Fibrillation in a Porcine Model}},
url = {{http://dx.doi.org/10.22489/CinC.2023.408}},
doi = {{10.22489/CinC.2023.408}},
year = {{2023}},
}