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Zinc and Breast Cancer Survival: A Prospective Cohort Study of Dietary Intake and Serum Levels

Bengtsson, Ylva LU orcid ; Demircan, Kamil ; Rosendahl, Ann LU ; Borgquist, Signe LU ; Sandsveden, Malte LU and Manjer, Jonas LU (2022) In Nutrients 14.
Abstract
Zinc has been suggested to play a role in breast cancer progression; however, no previous study on zinc levels and the potential effect on breast cancer survival has been conducted. This study investigates recurrence-free survival (RFS), breast cancer-specific survival (BCSS) and overall survival (OS) in relation to zinc levels, in serum and diet, overall and stratified for phosphorus and selenium levels. The Malmö Diet and Cancer Study, a prospective population-based cohort in Sweden including 17,035 women, was used to identify breast cancer patients diagnosed in the period 1991–2013. Diet was assessed by a validated modified diet history method. A Cox regression analysis yielded hazard ratios (HRs) with 95% confidence intervals adjusted... (More)
Zinc has been suggested to play a role in breast cancer progression; however, no previous study on zinc levels and the potential effect on breast cancer survival has been conducted. This study investigates recurrence-free survival (RFS), breast cancer-specific survival (BCSS) and overall survival (OS) in relation to zinc levels, in serum and diet, overall and stratified for phosphorus and selenium levels. The Malmö Diet and Cancer Study, a prospective population-based cohort in Sweden including 17,035 women, was used to identify breast cancer patients diagnosed in the period 1991–2013. Diet was assessed by a validated modified diet history method. A Cox regression analysis yielded hazard ratios (HRs) with 95% confidence intervals adjusted for potential confounders. Out of 1062 patients with invasive breast cancer, 268 recurrences, 205 breast cancer deaths and 228 deaths from other causes were recorded. No overall associations were seen between zinc and RFS, BCSS or OS. However, in women with a high phosphorus intake, a higher BCSS and OS were seen in zinc intake Q2 to Q4 versus Q1; the adjusted HR was 0.41 (0.23–0.73) and 0.64 (0.41–1.00), respectively. The results indicate that the combination of intermediate/high zinc intake and high phosphorus intake may lead to a better breast cancer survival. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nutrients
volume
14
article number
2575
publisher
MDPI AG
external identifiers
  • scopus:85132314365
  • pmid:35807763
ISSN
2072-6643
DOI
10.3390/nu14132575
project
Trace Elements and Breast Cancer: Selenium, Zinc and Copper in Relation to Risk and Prognosis
language
English
LU publication?
yes
id
bd21c08d-5a2b-430c-a34a-ec8845ab3193
date added to LUP
2022-07-25 18:28:25
date last changed
2024-05-17 12:59:14
@article{bd21c08d-5a2b-430c-a34a-ec8845ab3193,
  abstract     = {{Zinc has been suggested to play a role in breast cancer progression; however, no previous study on zinc levels and the potential effect on breast cancer survival has been conducted. This study investigates recurrence-free survival (RFS), breast cancer-specific survival (BCSS) and overall survival (OS) in relation to zinc levels, in serum and diet, overall and stratified for phosphorus and selenium levels. The Malmö Diet and Cancer Study, a prospective population-based cohort in Sweden including 17,035 women, was used to identify breast cancer patients diagnosed in the period 1991–2013. Diet was assessed by a validated modified diet history method. A Cox regression analysis yielded hazard ratios (HRs) with 95% confidence intervals adjusted for potential confounders. Out of 1062 patients with invasive breast cancer, 268 recurrences, 205 breast cancer deaths and 228 deaths from other causes were recorded. No overall associations were seen between zinc and RFS, BCSS or OS. However, in women with a high phosphorus intake, a higher BCSS and OS were seen in zinc intake Q2 to Q4 versus Q1; the adjusted HR was 0.41 (0.23–0.73) and 0.64 (0.41–1.00), respectively. The results indicate that the combination of intermediate/high zinc intake and high phosphorus intake may lead to a better breast cancer survival.}},
  author       = {{Bengtsson, Ylva and Demircan, Kamil and Rosendahl, Ann and Borgquist, Signe and Sandsveden, Malte and Manjer, Jonas}},
  issn         = {{2072-6643}},
  language     = {{eng}},
  month        = {{06}},
  publisher    = {{MDPI AG}},
  series       = {{Nutrients}},
  title        = {{Zinc and Breast Cancer Survival: A Prospective Cohort Study of Dietary Intake and Serum Levels}},
  url          = {{http://dx.doi.org/10.3390/nu14132575}},
  doi          = {{10.3390/nu14132575}},
  volume       = {{14}},
  year         = {{2022}},
}