Advanced

Midlife risk factor exposure and incidence of cardiac arrest depending on cardiac or non-cardiac origin

Ohlsson, Marcus Andreas LU ; Kennedy, Linn Maria Anna LU ; Juhlin, Tord LU and Melander, Olle LU (2017) In International Journal of Cardiology 240. p.398-402
Abstract

Objective: Little is known about midlife risk factors of future cardiac arrest. Our objective was to evaluate cardiovascular risk factors in midlife in relation to the risk of cardiac arrest (CA) of cardiac and non-cardiac origin later in life. Methods: We cross-matched individuals of the population based Malmö Diet and Cancer study (n = 30,447) with the local CA registry of the city of Malmö. Baseline exposures were related to incident CA. Results: During a mean follow-up of 17.6. ±. 4.6. years, 378 CA occurred, of whom 17.2% survived to discharge. Independent midlife risk factors for CA of cardiac origin included coronary artery disease (HR 2.84 (1.86-4.34) (p <. 0.001)), diabetes mellitus (HR 2.37 (1.61-3.51) (p <. 0.001)) and... (More)

Objective: Little is known about midlife risk factors of future cardiac arrest. Our objective was to evaluate cardiovascular risk factors in midlife in relation to the risk of cardiac arrest (CA) of cardiac and non-cardiac origin later in life. Methods: We cross-matched individuals of the population based Malmö Diet and Cancer study (n = 30,447) with the local CA registry of the city of Malmö. Baseline exposures were related to incident CA. Results: During a mean follow-up of 17.6. ±. 4.6. years, 378 CA occurred, of whom 17.2% survived to discharge. Independent midlife risk factors for CA of cardiac origin included coronary artery disease (HR 2.84 (1.86-4.34) (p <. 0.001)), diabetes mellitus (HR 2.37 (1.61-3.51) (p <. 0.001)) and smoking (HR 1.95 (1.49-2.55) (p <. 0.001)). Dyslipidemia and history of stroke were also significantly associated with an elevated risk for CA of cardiac origin.Independent midlife risk factors for CA of non-cardiac origin included obesity (BMI>30kg/m2) (HR 2.37 (1.51-3.71) (p <0.001)), smoking (HR 2.05 (1.33-3.15) (p <0.001)) and being on antihypertensive treatment (HR 2.25 (1.46-3.46) (p <0.001)). Conclusion: Apart from smoking, which increases the risk of CA in general, the midlife risk factor pattern differs between CA of cardiac and non-cardiac origin. Whereas CA of cardiac origin is predicted by history of cardiovascular disease, dyslipidemia and diabetes mellitus, the main risk factors for CA of non-cardiac origin are obesity and hypertension. In addition to control of classical cardiovascular risk factors for prevention of CA, our results suggest that prevention of midlife obesity may reduce the risk of CA of non-cardiac origin.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cardiology
volume
240
pages
398 - 402
publisher
Elsevier
external identifiers
  • scopus:85018442674
  • wos:000405454800072
ISSN
0167-5273
DOI
10.1016/j.ijcard.2017.05.004
language
English
LU publication?
yes
id
bd9b4321-b5d9-4681-943c-277e6b8b3cfc
date added to LUP
2017-05-19 10:51:27
date last changed
2018-01-07 12:04:24
@article{bd9b4321-b5d9-4681-943c-277e6b8b3cfc,
  abstract     = {<p>Objective: Little is known about midlife risk factors of future cardiac arrest. Our objective was to evaluate cardiovascular risk factors in midlife in relation to the risk of cardiac arrest (CA) of cardiac and non-cardiac origin later in life. Methods: We cross-matched individuals of the population based Malmö Diet and Cancer study (n = 30,447) with the local CA registry of the city of Malmö. Baseline exposures were related to incident CA. Results: During a mean follow-up of 17.6. ±. 4.6. years, 378 CA occurred, of whom 17.2% survived to discharge. Independent midlife risk factors for CA of cardiac origin included coronary artery disease (HR 2.84 (1.86-4.34) (p &lt;. 0.001)), diabetes mellitus (HR 2.37 (1.61-3.51) (p &lt;. 0.001)) and smoking (HR 1.95 (1.49-2.55) (p &lt;. 0.001)). Dyslipidemia and history of stroke were also significantly associated with an elevated risk for CA of cardiac origin.Independent midlife risk factors for CA of non-cardiac origin included obesity (BMI&gt;30kg/m<sup>2</sup>) (HR 2.37 (1.51-3.71) (p &lt;0.001)), smoking (HR 2.05 (1.33-3.15) (p &lt;0.001)) and being on antihypertensive treatment (HR 2.25 (1.46-3.46) (p &lt;0.001)). Conclusion: Apart from smoking, which increases the risk of CA in general, the midlife risk factor pattern differs between CA of cardiac and non-cardiac origin. Whereas CA of cardiac origin is predicted by history of cardiovascular disease, dyslipidemia and diabetes mellitus, the main risk factors for CA of non-cardiac origin are obesity and hypertension. In addition to control of classical cardiovascular risk factors for prevention of CA, our results suggest that prevention of midlife obesity may reduce the risk of CA of non-cardiac origin.</p>},
  author       = {Ohlsson, Marcus Andreas and Kennedy, Linn Maria Anna and Juhlin, Tord and Melander, Olle},
  issn         = {0167-5273},
  language     = {eng},
  pages        = {398--402},
  publisher    = {Elsevier},
  series       = {International Journal of Cardiology},
  title        = {Midlife risk factor exposure and incidence of cardiac arrest depending on cardiac or non-cardiac origin},
  url          = {http://dx.doi.org/10.1016/j.ijcard.2017.05.004},
  volume       = {240},
  year         = {2017},
}