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How to interpret differing cerebral blood flow patterns estimated with 99tcm-hmpao and 99tcm-ecd spet in a healthy population

Siennicki-Lantz, Arkadiusz LU orcid ; Elmståhl, Sölve LU and Lilja, B. (1999) In Nuclear Medicine Communications 20(3). p.219-226
Abstract

Two radiopharmaceuticals, 99Tcm-hexamethyl propylene amine oxime (99Tcm-HMPAO) and 99Tcm-ethyl cysteinate dimer (99Tcm-ECD), are currently used to determine cerebral blood flow. 99Tcm-ECD is, by virtue of its greater stability, superceding 99Tcm-HMPAO for routine examinations. Since the clinical assessment of 99Tcm-ECD images is usually based on experience with 99Tcm-HMPAO, we used both radiopharmaceuticals to compare regional cerebral blood flow in the same individuals. Eleven healthy subjects aged 67.1 ± 6.3 years (mean ± S.D.) underwent... (More)

Two radiopharmaceuticals, 99Tcm-hexamethyl propylene amine oxime (99Tcm-HMPAO) and 99Tcm-ethyl cysteinate dimer (99Tcm-ECD), are currently used to determine cerebral blood flow. 99Tcm-ECD is, by virtue of its greater stability, superceding 99Tcm-HMPAO for routine examinations. Since the clinical assessment of 99Tcm-ECD images is usually based on experience with 99Tcm-HMPAO, we used both radiopharmaceuticals to compare regional cerebral blood flow in the same individuals. Eleven healthy subjects aged 67.1 ± 6.3 years (mean ± S.D.) underwent 99Tcm-ECD followed by 99Tcm-HMPAO single photon emission tomography. Cerebral blood flow was quantified in cortical and central regions of interest (basal ganglia, ventricles, white matter) in relation to cerebellar uptake. The intra-subject comparison of cerebral blood flow in the cortical areas revealed higher levels of perfusion in the posterior parietal, parieto-occipital and temporo-occipital areas using 99Tcm-ECD. In contrast to the cortical areas, cerebral blood flow in the central areas was greater using 99Tcm-HMPAO, especially in the centrum semiovale, basal ganglia, frontal white matter and frontal horns. This difference in cerebral blood flow when imaging healthy individuals with 99Tcm-ECD and 99Tcm-HMPAO should be taken into account in clinical practice when changing from one radiopharmaceutical to the other.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nuclear Medicine Communications
volume
20
issue
3
pages
219 - 226
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:10093071
  • scopus:0032909737
ISSN
0143-3636
DOI
10.1097/00006231-199903000-00004
language
English
LU publication?
yes
id
bf3c7fd6-e370-4220-9db6-1c0d758bcc3c
date added to LUP
2019-06-19 11:03:55
date last changed
2024-04-16 11:58:09
@article{bf3c7fd6-e370-4220-9db6-1c0d758bcc3c,
  abstract     = {{<p>Two radiopharmaceuticals, <sup>99</sup>Tc<sup>m</sup>-hexamethyl propylene amine oxime (<sup>99</sup>Tc<sup>m</sup>-HMPAO) and <sup>99</sup>Tc<sup>m</sup>-ethyl cysteinate dimer (<sup>99</sup>Tc<sup>m</sup>-ECD), are currently used to determine cerebral blood flow. <sup>99</sup>Tc<sup>m</sup>-ECD is, by virtue of its greater stability, superceding <sup>99</sup>Tc<sup>m</sup>-HMPAO for routine examinations. Since the clinical assessment of <sup>99</sup>Tc<sup>m</sup>-ECD images is usually based on experience with <sup>99</sup>Tc<sup>m</sup>-HMPAO, we used both radiopharmaceuticals to compare regional cerebral blood flow in the same individuals. Eleven healthy subjects aged 67.1 ± 6.3 years (mean ± S.D.) underwent <sup>99</sup>Tc<sup>m</sup>-ECD followed by <sup>99</sup>Tc<sup>m</sup>-HMPAO single photon emission tomography. Cerebral blood flow was quantified in cortical and central regions of interest (basal ganglia, ventricles, white matter) in relation to cerebellar uptake. The intra-subject comparison of cerebral blood flow in the cortical areas revealed higher levels of perfusion in the posterior parietal, parieto-occipital and temporo-occipital areas using <sup>99</sup>Tc<sup>m</sup>-ECD. In contrast to the cortical areas, cerebral blood flow in the central areas was greater using <sup>99</sup>Tc<sup>m</sup>-HMPAO, especially in the centrum semiovale, basal ganglia, frontal white matter and frontal horns. This difference in cerebral blood flow when imaging healthy individuals with <sup>99</sup>Tc<sup>m</sup>-ECD and <sup>99</sup>Tc<sup>m</sup>-HMPAO should be taken into account in clinical practice when changing from one radiopharmaceutical to the other.</p>}},
  author       = {{Siennicki-Lantz, Arkadiusz and Elmståhl, Sölve and Lilja, B.}},
  issn         = {{0143-3636}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{219--226}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Nuclear Medicine Communications}},
  title        = {{How to interpret differing cerebral blood flow patterns estimated with <sup>99</sup>tc<sup>m</sup>-hmpao and <sup>99</sup>tc<sup>m</sup>-ecd spet in a healthy population}},
  url          = {{http://dx.doi.org/10.1097/00006231-199903000-00004}},
  doi          = {{10.1097/00006231-199903000-00004}},
  volume       = {{20}},
  year         = {{1999}},
}