Human malignant melanoma heterotransplanted to nude mice
Trope, C. ; Johnsson, J. E. ; Alm, P. LU ; Landberg, T. LU ; Olsson, Håkan LU
and Wennerberg, J.
LU
(1981)
In Neoplasma
28(5).
p.585-591
- Abstract
- Five different human malignant melanoma were heterotransplanted subcutaneously to nude mice. When small tissue pieces were used 3 out of 5 tumors grew. Subcutaneous injections of suspended tumor cells were also made, but all failed to take. Metastatic or infiltrative growth was never seen in the mice observed for up to 2.5 months. The successful grafts largely retained the original morphological features. The three successfully transplanted tumors could all be serially transfered with 100% tumor take. In one case passage time was reduced from 40 days to 15 days. As measured with 3H-thymidine incorporation the proliferation rate increased during the passages. These changes might be due to a selection of more rapidly growing tumor cells in... (More)
- Five different human malignant melanoma were heterotransplanted subcutaneously to nude mice. When small tissue pieces were used 3 out of 5 tumors grew. Subcutaneous injections of suspended tumor cells were also made, but all failed to take. Metastatic or infiltrative growth was never seen in the mice observed for up to 2.5 months. The successful grafts largely retained the original morphological features. The three successfully transplanted tumors could all be serially transfered with 100% tumor take. In one case passage time was reduced from 40 days to 15 days. As measured with 3H-thymidine incorporation the proliferation rate increased during the passages. These changes might be due to a selection of more rapidly growing tumor cells in the nudes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/c0b82aff-fc3f-4832-8812-d4cc0b938398
- author
- Trope, C.
; Johnsson, J. E.
; Alm, P.
LU
; Landberg, T.
LU
; Olsson, Håkan
LU
and Wennerberg, J.
LU
- organization
- publishing date
- 1981
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neoplasma
- volume
- 28
- issue
- 5
- pages
- 7 pages
- publisher
- Vydavatel'stvo Slovenkej Akademie Vied/Veda Publishing House of the Slovak Academy of Sciences
- external identifiers
-
- scopus:0019808295
- language
- English
- LU publication?
- yes
- additional info
- Cited By :3 Export Date: 11 December 2018
- id
- c0b82aff-fc3f-4832-8812-d4cc0b938398
- alternative location
- https://www.scopus.com/inward/record.uri?eid=2-s2.0-0019808295&partnerID=40&md5=5a3e0170e544baa3b1d5b5e38728ee2d
- date added to LUP
- 2018-12-11 16:39:11
- date last changed
- 2021-08-29 04:59:15
@article{c0b82aff-fc3f-4832-8812-d4cc0b938398,
abstract = {{Five different human malignant melanoma were heterotransplanted subcutaneously to nude mice. When small tissue pieces were used 3 out of 5 tumors grew. Subcutaneous injections of suspended tumor cells were also made, but all failed to take. Metastatic or infiltrative growth was never seen in the mice observed for up to 2.5 months. The successful grafts largely retained the original morphological features. The three successfully transplanted tumors could all be serially transfered with 100% tumor take. In one case passage time was reduced from 40 days to 15 days. As measured with 3H-thymidine incorporation the proliferation rate increased during the passages. These changes might be due to a selection of more rapidly growing tumor cells in the nudes.}},
author = {{Trope, C. and Johnsson, J. E. and Alm, P. and Landberg, T. and Olsson, Håkan and Wennerberg, J.}},
language = {{eng}},
number = {{5}},
pages = {{585--591}},
publisher = {{Vydavatel'stvo Slovenkej Akademie Vied/Veda Publishing House of the Slovak Academy of Sciences}},
series = {{Neoplasma}},
title = {{Human malignant melanoma heterotransplanted to nude mice}},
url = {{https://www.scopus.com/inward/record.uri?eid=2-s2.0-0019808295&partnerID=40&md5=5a3e0170e544baa3b1d5b5e38728ee2d}},
volume = {{28}},
year = {{1981}},
}