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Human malignant melanoma heterotransplanted to nude mice

Trope, C.; Johnsson, J. E.; Alm, P. LU ; Landberg, T. LU ; Olsson, Håkan LU and Wennerberg, J. LU (1981) In Neoplasma 28(5). p.585-591
Abstract
Five different human malignant melanoma were heterotransplanted subcutaneously to nude mice. When small tissue pieces were used 3 out of 5 tumors grew. Subcutaneous injections of suspended tumor cells were also made, but all failed to take. Metastatic or infiltrative growth was never seen in the mice observed for up to 2.5 months. The successful grafts largely retained the original morphological features. The three successfully transplanted tumors could all be serially transfered with 100% tumor take. In one case passage time was reduced from 40 days to 15 days. As measured with 3H-thymidine incorporation the proliferation rate increased during the passages. These changes might be due to a selection of more rapidly growing tumor cells in... (More)
Five different human malignant melanoma were heterotransplanted subcutaneously to nude mice. When small tissue pieces were used 3 out of 5 tumors grew. Subcutaneous injections of suspended tumor cells were also made, but all failed to take. Metastatic or infiltrative growth was never seen in the mice observed for up to 2.5 months. The successful grafts largely retained the original morphological features. The three successfully transplanted tumors could all be serially transfered with 100% tumor take. In one case passage time was reduced from 40 days to 15 days. As measured with 3H-thymidine incorporation the proliferation rate increased during the passages. These changes might be due to a selection of more rapidly growing tumor cells in the nudes. (Less)
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published
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Neoplasma
volume
28
issue
5
pages
7 pages
external identifiers
  • scopus:0019808295
language
English
LU publication?
yes
id
c0b82aff-fc3f-4832-8812-d4cc0b938398
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-0019808295&partnerID=40&md5=5a3e0170e544baa3b1d5b5e38728ee2d
date added to LUP
2018-12-11 16:39:11
date last changed
2019-01-06 14:19:42
@article{c0b82aff-fc3f-4832-8812-d4cc0b938398,
  abstract     = {Five different human malignant melanoma were heterotransplanted subcutaneously to nude mice. When small tissue pieces were used 3 out of 5 tumors grew. Subcutaneous injections of suspended tumor cells were also made, but all failed to take. Metastatic or infiltrative growth was never seen in the mice observed for up to 2.5 months. The successful grafts largely retained the original morphological features. The three successfully transplanted tumors could all be serially transfered with 100% tumor take. In one case passage time was reduced from 40 days to 15 days. As measured with 3H-thymidine incorporation the proliferation rate increased during the passages. These changes might be due to a selection of more rapidly growing tumor cells in the nudes.},
  author       = {Trope, C. and Johnsson, J. E. and Alm, P. and Landberg, T. and Olsson, Håkan and Wennerberg, J.},
  language     = {eng},
  number       = {5},
  pages        = {585--591},
  series       = {Neoplasma},
  title        = {Human malignant melanoma heterotransplanted to nude mice},
  volume       = {28},
  year         = {1981},
}