Electrochemical molecularly imprinted polymer sensors in viral diagnostics : Innovations, challenges and case studies
Gritsok, Dmitrij ; Hedström, Martin LU
; Montenegro, Maria C.B.S.M.
and Amorim, Célia Gomes
(2025)
In Biosensors and Bioelectronics
287.
- Abstract
Molecularly imprinted polymers (MIPs) are synthetic equivalent of antibodies and have been widely used in electrochemical sensing as recognition elements. They offer advantages over traditional recognition elements such as antibodies, nucleic acids and aptamers due to their simple synthesis, lower production costs, greater chemical and physical stability, and robust performance in diverse environments. Improved detection techniques and combining MIPs with materials like metal nanoparticles, carbon nanotubes, aptamers, metal organic frameworks, quantum dots, and electrochemically active internal probes show increasing potential. These combinations could become a reliable method for detecting viruses quickly, with performance similar or... (More)
Molecularly imprinted polymers (MIPs) are synthetic equivalent of antibodies and have been widely used in electrochemical sensing as recognition elements. They offer advantages over traditional recognition elements such as antibodies, nucleic acids and aptamers due to their simple synthesis, lower production costs, greater chemical and physical stability, and robust performance in diverse environments. Improved detection techniques and combining MIPs with materials like metal nanoparticles, carbon nanotubes, aptamers, metal organic frameworks, quantum dots, and electrochemically active internal probes show increasing potential. These combinations could become a reliable method for detecting viruses quickly, with performance similar or better than standard techniques. In this review article we provide detailed case studies covering ten different viruses (Bean pod mottle virus, Dengue virus, Zika virus, Foot-and-mouth disease virus, Human papillomavirus, Hepatitis C virus, Human immunodeficiency virus, Influenza A virus, Norovirus, Severe acute respiratory syndrome coronavirus 2) and over forty specific examples. We summarize the recent advances in the development of electrochemical MIP-based sensors for the diagnostics of viral diseases and compare their performance. Additionally, challenges and future perspectives of MIPs as promising recognition elements are discussed.
(Less)
- author
- Gritsok, Dmitrij
; Hedström, Martin
LU
; Montenegro, Maria C.B.S.M.
and Amorim, Célia Gomes
- organization
- publishing date
- 2025-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Electrochemical sensors, Molecularly imprinted polymers, Virus diagnostics
- in
- Biosensors and Bioelectronics
- volume
- 287
- article number
- 117678
- publisher
- Elsevier
- external identifiers
-
- scopus:105007728972
- pmid:40513291
- ISSN
- 0956-5663
- DOI
- 10.1016/j.bios.2025.117678
- language
- English
- LU publication?
- yes
- id
- c0ff7908-91aa-4487-913f-7cf76960d6d7
- date added to LUP
- 2025-10-27 12:51:34
- date last changed
- 2025-10-27 12:52:53
@article{c0ff7908-91aa-4487-913f-7cf76960d6d7,
abstract = {{<p>Molecularly imprinted polymers (MIPs) are synthetic equivalent of antibodies and have been widely used in electrochemical sensing as recognition elements. They offer advantages over traditional recognition elements such as antibodies, nucleic acids and aptamers due to their simple synthesis, lower production costs, greater chemical and physical stability, and robust performance in diverse environments. Improved detection techniques and combining MIPs with materials like metal nanoparticles, carbon nanotubes, aptamers, metal organic frameworks, quantum dots, and electrochemically active internal probes show increasing potential. These combinations could become a reliable method for detecting viruses quickly, with performance similar or better than standard techniques. In this review article we provide detailed case studies covering ten different viruses (Bean pod mottle virus, Dengue virus, Zika virus, Foot-and-mouth disease virus, Human papillomavirus, Hepatitis C virus, Human immunodeficiency virus, Influenza A virus, Norovirus, Severe acute respiratory syndrome coronavirus 2) and over forty specific examples. We summarize the recent advances in the development of electrochemical MIP-based sensors for the diagnostics of viral diseases and compare their performance. Additionally, challenges and future perspectives of MIPs as promising recognition elements are discussed.</p>}},
author = {{Gritsok, Dmitrij and Hedström, Martin and Montenegro, Maria C.B.S.M. and Amorim, Célia Gomes}},
issn = {{0956-5663}},
keywords = {{Electrochemical sensors; Molecularly imprinted polymers; Virus diagnostics}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Biosensors and Bioelectronics}},
title = {{Electrochemical molecularly imprinted polymer sensors in viral diagnostics : Innovations, challenges and case studies}},
url = {{http://dx.doi.org/10.1016/j.bios.2025.117678}},
doi = {{10.1016/j.bios.2025.117678}},
volume = {{287}},
year = {{2025}},
}