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Long-Term Changes to the Microbiome, Blood Lipid Profiles and IL-6 in Female and Male Swedish Patients in Response to Bariatric Roux-en-Y Gastric Bypass

Prykhodko, Olena LU ; Burleigh, Stephen LU ; Campanello, Magnus ; Iresjö, Britt-Marie ; Zilling, Thomas LU ; Ljungh, Åsa LU ; Smedh, Ulrika LU and Hållenius, Frida Fåk LU orcid (2024) In Nutrients 16(4).
Abstract

Lipid metabolism dysregulation is a critical factor contributing to obesity. To counteract obesity-associated disorders, bariatric surgery is implemented as a very effective method. However, surgery such as Roux-en-Y gastric bypass (RYGB) is irreversible, resulting in life-long changes to the digestive tract. The aim of the present study was to elucidate changes in the fecal microbiota before and after RYGB in relation to blood lipid profiles and proinflammatory IL-6. Here, we studied the long-term effects, up to six years after the RYGB procedure, on 15 patients’ gut microbiomes and their post-surgery well-being, emphasizing the biological sex of the patients. The results showed improved health among the patients after surgery, which... (More)

Lipid metabolism dysregulation is a critical factor contributing to obesity. To counteract obesity-associated disorders, bariatric surgery is implemented as a very effective method. However, surgery such as Roux-en-Y gastric bypass (RYGB) is irreversible, resulting in life-long changes to the digestive tract. The aim of the present study was to elucidate changes in the fecal microbiota before and after RYGB in relation to blood lipid profiles and proinflammatory IL-6. Here, we studied the long-term effects, up to six years after the RYGB procedure, on 15 patients’ gut microbiomes and their post-surgery well-being, emphasizing the biological sex of the patients. The results showed improved health among the patients after surgery, which coincided with weight loss and improved lipid metabolism. Health changes were associated with decreased inflammation and significant alterations in the gut microbiome after surgery that differed between females and males. The Actinobacteriota phylum decreased in females and increased in males. Overall increases in the genera Prevotella, Paraprevotella, Gemella, Streptococcus, and Veillonella_A, and decreases in Bacteroides_H, Anaerostipes, Lachnoclostridium_B, Hydrogeniiclostridium, Lawsonibacter, Paludicola, and Rothia were observed. In conclusion, our findings indicate that there were long-term changes in the gut microbiota after RYGB, and shifts in the microbial taxa appeared to differ depending on sex, which should be investigated further in a larger cohort.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Male, Female, Gastric Bypass/methods, Obesity, Morbid/surgery, Interleukin-6, Sweden, Obesity/surgery, Gastrointestinal Microbiome/physiology, Lactobacillales
in
Nutrients
volume
16
issue
4
article number
498
pages
12 pages
publisher
MDPI AG
external identifiers
  • pmid:38398821
  • scopus:85185947467
  • pmid:38398821
ISSN
2072-6643
DOI
10.3390/nu16040498
language
English
LU publication?
yes
id
c1797c8f-2a16-451f-9011-9447078c5796
date added to LUP
2024-03-13 13:22:52
date last changed
2024-05-22 13:13:58
@article{c1797c8f-2a16-451f-9011-9447078c5796,
  abstract     = {{<p>Lipid metabolism dysregulation is a critical factor contributing to obesity. To counteract obesity-associated disorders, bariatric surgery is implemented as a very effective method. However, surgery such as Roux-en-Y gastric bypass (RYGB) is irreversible, resulting in life-long changes to the digestive tract. The aim of the present study was to elucidate changes in the fecal microbiota before and after RYGB in relation to blood lipid profiles and proinflammatory IL-6. Here, we studied the long-term effects, up to six years after the RYGB procedure, on 15 patients’ gut microbiomes and their post-surgery well-being, emphasizing the biological sex of the patients. The results showed improved health among the patients after surgery, which coincided with weight loss and improved lipid metabolism. Health changes were associated with decreased inflammation and significant alterations in the gut microbiome after surgery that differed between females and males. The Actinobacteriota phylum decreased in females and increased in males. Overall increases in the genera Prevotella, Paraprevotella, Gemella, Streptococcus, and Veillonella_A, and decreases in Bacteroides_H, Anaerostipes, Lachnoclostridium_B, Hydrogeniiclostridium, Lawsonibacter, Paludicola, and Rothia were observed. In conclusion, our findings indicate that there were long-term changes in the gut microbiota after RYGB, and shifts in the microbial taxa appeared to differ depending on sex, which should be investigated further in a larger cohort.</p>}},
  author       = {{Prykhodko, Olena and Burleigh, Stephen and Campanello, Magnus and Iresjö, Britt-Marie and Zilling, Thomas and Ljungh, Åsa and Smedh, Ulrika and Hållenius, Frida Fåk}},
  issn         = {{2072-6643}},
  keywords     = {{Humans; Male; Female; Gastric Bypass/methods; Obesity, Morbid/surgery; Interleukin-6; Sweden; Obesity/surgery; Gastrointestinal Microbiome/physiology; Lactobacillales}},
  language     = {{eng}},
  number       = {{4}},
  publisher    = {{MDPI AG}},
  series       = {{Nutrients}},
  title        = {{Long-Term Changes to the Microbiome, Blood Lipid Profiles and IL-6 in Female and Male Swedish Patients in Response to Bariatric Roux-en-Y Gastric Bypass}},
  url          = {{http://dx.doi.org/10.3390/nu16040498}},
  doi          = {{10.3390/nu16040498}},
  volume       = {{16}},
  year         = {{2024}},
}