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alpha-ketoglutarate (AKG) absorption from pig intestine and plasma pharmacokinetics

Dabek, M ; Kruszewska, Danuta LU ; Filip, R ; Hotowy, A ; Pierzynowski, L ; Wojtasz-Pajak, A ; Szymanczyk, S ; Piedra, J L V ; Werpachowska, E and Pierzynowski, Stefan LU (2005) In Journal of Animal Physiology and Animal Nutrition 89(11-12). p.419-426
Abstract
To study the absorption, metabolism and kinetics, the AKG ( in different concentrations) was administered intravenously, intra-portally, orally and directly into the ileum or duodenum of pigs, chronically fitted with portal and jugular catheters and T-shaped cannula at the duodenum and ileum. Additionally, this study was conducted to determine the influence of low pH, Fe2+ or/ and SO42- on AKG gut absorption and conversely FeSO4 and FeSO4/AKG on Fe2+ gut absorption. It is concluded that AKG was significantly better absorbed from the upper small intestine than from the distal sections. Furthermore, low pH, Fe2+ and/or SO42- ions enhanced AKG absorption. The AKG administered to the portal vein was rapidly eliminated from the blood (half-life... (More)
To study the absorption, metabolism and kinetics, the AKG ( in different concentrations) was administered intravenously, intra-portally, orally and directly into the ileum or duodenum of pigs, chronically fitted with portal and jugular catheters and T-shaped cannula at the duodenum and ileum. Additionally, this study was conducted to determine the influence of low pH, Fe2+ or/ and SO42- on AKG gut absorption and conversely FeSO4 and FeSO4/AKG on Fe2+ gut absorption. It is concluded that AKG was significantly better absorbed from the upper small intestine than from the distal sections. Furthermore, low pH, Fe2+ and/or SO42- ions enhanced AKG absorption. The AKG administered to the portal vein was rapidly eliminated from the blood (half-life less than 5 min). The short lifetime for AKG is probably dependent on quick metabolism in the enteorcyetes and liver. However, the prolonged half-life can be related to its low AKG blood concentration. The Fe2+ concentrations in blood increased after FeSO4 and FeSO4/AKG duodenal infusion. The implication of above observations is important for practical application of the AKG in animal and human nutrition as well in medicine. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Animal Physiology and Animal Nutrition
volume
89
issue
11-12
pages
419 - 426
publisher
Wiley-Blackwell
external identifiers
  • pmid:16401194
  • wos:000233530100008
  • scopus:28944447958
ISSN
0931-2439
DOI
10.1111/j.1439-0396.2005.00566.x
language
English
LU publication?
yes
id
c1b9f243-8d11-4f9d-af73-df0b54c5f10d (old id 212164)
date added to LUP
2016-04-01 16:03:24
date last changed
2025-04-04 14:09:05
@article{c1b9f243-8d11-4f9d-af73-df0b54c5f10d,
  abstract     = {{To study the absorption, metabolism and kinetics, the AKG ( in different concentrations) was administered intravenously, intra-portally, orally and directly into the ileum or duodenum of pigs, chronically fitted with portal and jugular catheters and T-shaped cannula at the duodenum and ileum. Additionally, this study was conducted to determine the influence of low pH, Fe2+ or/ and SO42- on AKG gut absorption and conversely FeSO4 and FeSO4/AKG on Fe2+ gut absorption. It is concluded that AKG was significantly better absorbed from the upper small intestine than from the distal sections. Furthermore, low pH, Fe2+ and/or SO42- ions enhanced AKG absorption. The AKG administered to the portal vein was rapidly eliminated from the blood (half-life less than 5 min). The short lifetime for AKG is probably dependent on quick metabolism in the enteorcyetes and liver. However, the prolonged half-life can be related to its low AKG blood concentration. The Fe2+ concentrations in blood increased after FeSO4 and FeSO4/AKG duodenal infusion. The implication of above observations is important for practical application of the AKG in animal and human nutrition as well in medicine.}},
  author       = {{Dabek, M and Kruszewska, Danuta and Filip, R and Hotowy, A and Pierzynowski, L and Wojtasz-Pajak, A and Szymanczyk, S and Piedra, J L V and Werpachowska, E and Pierzynowski, Stefan}},
  issn         = {{0931-2439}},
  language     = {{eng}},
  number       = {{11-12}},
  pages        = {{419--426}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Animal Physiology and Animal Nutrition}},
  title        = {{alpha-ketoglutarate (AKG) absorption from pig intestine and plasma pharmacokinetics}},
  url          = {{http://dx.doi.org/10.1111/j.1439-0396.2005.00566.x}},
  doi          = {{10.1111/j.1439-0396.2005.00566.x}},
  volume       = {{89}},
  year         = {{2005}},
}