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MafB-dependent neurotransmitter signaling promotes β cell migration in the developing pancreas

Bsharat, Sara LU ; Monni, Emanuela LU ; Singh, Tania LU ; Johansson, Jenny K LU ; Achanta, Kavya LU ; Bertonnier-Brouty, Ludivine LU ; Schmidt-Christensen, Anja LU orcid ; Holmberg, Dan LU ; Kokaia, Zaal LU orcid and Prasad, Rashmi B LU , et al. (2023) In Development: For advances in developmental biology and stem cells 150(6).
Abstract

Hormone secretion from pancreatic islets is essential for glucose homeostasis and loss or dysfunction of islet cells is a hallmark of type 2 diabetes. Maf transcription factors are critical for establishing and maintaining adult endocrine cell function. However, during pancreas development, MafB is not only expressed in insulin- and glucagon-producing cells, but also Neurog3+ endocrine progenitor cells suggesting additional functions in cell differentiation and islet formation. Here we report that MafB deficiency impairs β cell clustering and islet formation, but also coincides with loss of neurotransmitter and axon guidance receptor gene expression. Moreover, the observed loss of nicotinic receptor gene expression in human and mouse β... (More)

Hormone secretion from pancreatic islets is essential for glucose homeostasis and loss or dysfunction of islet cells is a hallmark of type 2 diabetes. Maf transcription factors are critical for establishing and maintaining adult endocrine cell function. However, during pancreas development, MafB is not only expressed in insulin- and glucagon-producing cells, but also Neurog3+ endocrine progenitor cells suggesting additional functions in cell differentiation and islet formation. Here we report that MafB deficiency impairs β cell clustering and islet formation, but also coincides with loss of neurotransmitter and axon guidance receptor gene expression. Moreover, the observed loss of nicotinic receptor gene expression in human and mouse β cells implied that signaling through these receptors contributes to islet cell migration/formation. Inhibition of nicotinic receptor activity resulted in reduced β cell migration towards autonomic nerves and impaired β cell clustering. These findings highlight a novel function of MafB in controlling neuronal-directed signaling events required for islet formation.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Development: For advances in developmental biology and stem cells
volume
150
issue
6
article number
dev201009
publisher
The Company of Biologists Ltd
external identifiers
  • scopus:85151044363
  • pmid:36897571
ISSN
0950-1991
DOI
10.1242/dev.201009
language
English
LU publication?
yes
id
c1f30173-a4d4-49a0-8373-d9528c184f16
date added to LUP
2023-03-12 14:18:07
date last changed
2024-06-15 01:35:04
@article{c1f30173-a4d4-49a0-8373-d9528c184f16,
  abstract     = {{<p>Hormone secretion from pancreatic islets is essential for glucose homeostasis and loss or dysfunction of islet cells is a hallmark of type 2 diabetes. Maf transcription factors are critical for establishing and maintaining adult endocrine cell function. However, during pancreas development, MafB is not only expressed in insulin- and glucagon-producing cells, but also Neurog3+ endocrine progenitor cells suggesting additional functions in cell differentiation and islet formation. Here we report that MafB deficiency impairs β cell clustering and islet formation, but also coincides with loss of neurotransmitter and axon guidance receptor gene expression. Moreover, the observed loss of nicotinic receptor gene expression in human and mouse β cells implied that signaling through these receptors contributes to islet cell migration/formation. Inhibition of nicotinic receptor activity resulted in reduced β cell migration towards autonomic nerves and impaired β cell clustering. These findings highlight a novel function of MafB in controlling neuronal-directed signaling events required for islet formation.</p>}},
  author       = {{Bsharat, Sara and Monni, Emanuela and Singh, Tania and Johansson, Jenny K and Achanta, Kavya and Bertonnier-Brouty, Ludivine and Schmidt-Christensen, Anja and Holmberg, Dan and Kokaia, Zaal and Prasad, Rashmi B and Artner, Isabella}},
  issn         = {{0950-1991}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{6}},
  publisher    = {{The Company of Biologists Ltd}},
  series       = {{Development: For advances in developmental biology and stem cells}},
  title        = {{MafB-dependent neurotransmitter signaling promotes β cell migration in the developing pancreas}},
  url          = {{http://dx.doi.org/10.1242/dev.201009}},
  doi          = {{10.1242/dev.201009}},
  volume       = {{150}},
  year         = {{2023}},
}