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Genetic predisposition for multiple myeloma

Pertesi, Maroulio LU ; Went, Molly ; Hansson, Markus LU orcid ; Hemminki, Kari LU ; Houlston, Richard S. and Nilsson, Björn LU (2020) In Leukemia 34(3). p.697-708
Abstract

Multiple myeloma (MM) is the second most common blood malignancy. Epidemiological family studies going back to the 1920s have provided evidence for familial aggregation, suggesting a subset of cases have an inherited genetic background. Recently, studies aimed at explaining this phenomenon have begun to provide direct evidence for genetic predisposition to MM. Genome-wide association studies have identified common risk alleles at 24 independent loci. Sequencing studies of familial cases and kindreds have begun to identify promising candidate genes where variants with strong effects on MM risk might reside. Finally, functional studies are starting to give insight into how identified risk alleles promote the development of MM. Here, we... (More)

Multiple myeloma (MM) is the second most common blood malignancy. Epidemiological family studies going back to the 1920s have provided evidence for familial aggregation, suggesting a subset of cases have an inherited genetic background. Recently, studies aimed at explaining this phenomenon have begun to provide direct evidence for genetic predisposition to MM. Genome-wide association studies have identified common risk alleles at 24 independent loci. Sequencing studies of familial cases and kindreds have begun to identify promising candidate genes where variants with strong effects on MM risk might reside. Finally, functional studies are starting to give insight into how identified risk alleles promote the development of MM. Here, we review recent findings in MM predisposition field, and highlight open questions and future directions.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Leukemia
volume
34
issue
3
pages
12 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85077707182
  • pmid:31913320
ISSN
0887-6924
DOI
10.1038/s41375-019-0703-6
language
English
LU publication?
yes
id
c26d4667-9389-425b-8eab-5c4115dea17a
date added to LUP
2020-01-29 14:14:35
date last changed
2022-05-12 00:08:48
@article{c26d4667-9389-425b-8eab-5c4115dea17a,
  abstract     = {{<p>Multiple myeloma (MM) is the second most common blood malignancy. Epidemiological family studies going back to the 1920s have provided evidence for familial aggregation, suggesting a subset of cases have an inherited genetic background. Recently, studies aimed at explaining this phenomenon have begun to provide direct evidence for genetic predisposition to MM. Genome-wide association studies have identified common risk alleles at 24 independent loci. Sequencing studies of familial cases and kindreds have begun to identify promising candidate genes where variants with strong effects on MM risk might reside. Finally, functional studies are starting to give insight into how identified risk alleles promote the development of MM. Here, we review recent findings in MM predisposition field, and highlight open questions and future directions.</p>}},
  author       = {{Pertesi, Maroulio and Went, Molly and Hansson, Markus and Hemminki, Kari and Houlston, Richard S. and Nilsson, Björn}},
  issn         = {{0887-6924}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{697--708}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Leukemia}},
  title        = {{Genetic predisposition for multiple myeloma}},
  url          = {{http://dx.doi.org/10.1038/s41375-019-0703-6}},
  doi          = {{10.1038/s41375-019-0703-6}},
  volume       = {{34}},
  year         = {{2020}},
}