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Regeneration across a partial defect in rat sciatic nerve encased in a silicone chamber

Urabe, Tadahisa; Zhao, Q; Danielsen, N LU and Lundborg, G LU (1996) In Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery1987-01-01+01:002010-01-01+01:00 30(1). p.7-15
Abstract

Forty-four rat sciatic nerves with partial defects were repaired with a silicone chamber. Each partial defect was created by resecting a 10 mm segment from the tibial fascicle leaving the peroneal fascicle intact. The proximal and the distal stumps of the tibial fascicle together with the intact peroneal fascicle were encased in a single silicone chamber. After seven days a fibrin matrix had surrounded the peroneal fascicle and spanned the defect between the tibial stumps. This matrix was later invaded by non-neuronal cells and regenerating axons. Non-myelinated nerve fibres had almost regenerated across the defect by 16 days. The tetanic force of the gastrocnemius muscle 120 days after repair showed 80% recovery, which was no different... (More)

Forty-four rat sciatic nerves with partial defects were repaired with a silicone chamber. Each partial defect was created by resecting a 10 mm segment from the tibial fascicle leaving the peroneal fascicle intact. The proximal and the distal stumps of the tibial fascicle together with the intact peroneal fascicle were encased in a single silicone chamber. After seven days a fibrin matrix had surrounded the peroneal fascicle and spanned the defect between the tibial stumps. This matrix was later invaded by non-neuronal cells and regenerating axons. Non-myelinated nerve fibres had almost regenerated across the defect by 16 days. The tetanic force of the gastrocnemius muscle 120 days after repair showed 80% recovery, which was no different from that of partial defects repaired with conventional nerve grafts. The results suggest that the silicone chamber technique could be applicable to the treatment of partially transected nerve trunks.

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organization
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Contribution to journal
publication status
published
subject
keywords
Animals, Female, Immunohistochemistry, Muscle Contraction, Nerve Regeneration, Rats, Rats, Wistar, Sciatic Nerve, Silicones, Journal Article, Research Support, Non-U.S. Gov't
in
Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery1987-01-01+01:002010-01-01+01:00
volume
30
issue
1
pages
9 pages
publisher
Taylor & Francis
external identifiers
  • scopus:0029986933
ISSN
0284-4311
language
English
LU publication?
yes
id
c297cf8d-0a1e-4093-87b5-ed10fd38ddd7
date added to LUP
2017-10-13 13:38:14
date last changed
2017-11-30 08:23:54
@article{c297cf8d-0a1e-4093-87b5-ed10fd38ddd7,
  abstract     = {<p>Forty-four rat sciatic nerves with partial defects were repaired with a silicone chamber. Each partial defect was created by resecting a 10 mm segment from the tibial fascicle leaving the peroneal fascicle intact. The proximal and the distal stumps of the tibial fascicle together with the intact peroneal fascicle were encased in a single silicone chamber. After seven days a fibrin matrix had surrounded the peroneal fascicle and spanned the defect between the tibial stumps. This matrix was later invaded by non-neuronal cells and regenerating axons. Non-myelinated nerve fibres had almost regenerated across the defect by 16 days. The tetanic force of the gastrocnemius muscle 120 days after repair showed 80% recovery, which was no different from that of partial defects repaired with conventional nerve grafts. The results suggest that the silicone chamber technique could be applicable to the treatment of partially transected nerve trunks.</p>},
  author       = {Urabe, Tadahisa and Zhao, Q and Danielsen, N and Lundborg, G},
  issn         = {0284-4311},
  keyword      = {Animals,Female,Immunohistochemistry,Muscle Contraction,Nerve Regeneration,Rats,Rats, Wistar,Sciatic Nerve,Silicones,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {1},
  pages        = {7--15},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery1987-01-01+01:002010-01-01+01:00},
  title        = {Regeneration across a partial defect in rat sciatic nerve encased in a silicone chamber},
  volume       = {30},
  year         = {1996},
}