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Neuroendocrine differentiation in male breast carcinomas

ALM, PER LU ; ALUMETS, JAN LU ; BAK‐JENSEN, ELISABET and OLSSON, HÅKAN LU (1992) In APMIS1988-01-01+01:00 100(7-12). p.720-726
Abstract

The presence of neuroendocrine differentiation, as expressed by cellular chromogranin immunoreactivity, was investigated in paraffin‐embedded tissue material from 51 consecutive cases of male breast carcinoma. From six of these cases electron microscopic studies were included. Chromogranin‐immunoreactive cells were present in solid cords and delineated tubular structures. Ultrastructurally, dense core secretory granules could be detected. The expression of neuroendocrine differentiation was 45%, which is between two and eight times higher than reported for female breast carcinomas by other investigators. The present findings suggest that male breast carcinoma is an exclusive tumour disease showing both similarities and discrepancies... (More)

The presence of neuroendocrine differentiation, as expressed by cellular chromogranin immunoreactivity, was investigated in paraffin‐embedded tissue material from 51 consecutive cases of male breast carcinoma. From six of these cases electron microscopic studies were included. Chromogranin‐immunoreactive cells were present in solid cords and delineated tubular structures. Ultrastructurally, dense core secretory granules could be detected. The expression of neuroendocrine differentiation was 45%, which is between two and eight times higher than reported for female breast carcinomas by other investigators. The present findings suggest that male breast carcinoma is an exclusive tumour disease showing both similarities and discrepancies when compared to its female counterpart.

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author
organization
publishing date
type
Contribution to journal
publication status
published
keywords
Breast carcinoma, immunohistochemistry, neuroendocrine differentiation
in
APMIS1988-01-01+01:00
volume
100
issue
7-12
pages
720 - 726
publisher
John Wiley & Sons
external identifiers
  • scopus:0026782761
ISSN
0903-4641
DOI
10.1111/j.1699-0463.1992.tb03990.x
language
English
LU publication?
yes
id
c29b3703-04db-40ec-a148-a83a10d80af1
date added to LUP
2018-12-19 15:48:32
date last changed
2019-01-06 14:20:55
@article{c29b3703-04db-40ec-a148-a83a10d80af1,
  abstract     = {<p>The presence of neuroendocrine differentiation, as expressed by cellular chromogranin immunoreactivity, was investigated in paraffin‐embedded tissue material from 51 consecutive cases of male breast carcinoma. From six of these cases electron microscopic studies were included. Chromogranin‐immunoreactive cells were present in solid cords and delineated tubular structures. Ultrastructurally, dense core secretory granules could be detected. The expression of neuroendocrine differentiation was 45%, which is between two and eight times higher than reported for female breast carcinomas by other investigators. The present findings suggest that male breast carcinoma is an exclusive tumour disease showing both similarities and discrepancies when compared to its female counterpart.</p>},
  author       = {ALM, PER and ALUMETS, JAN and BAK‐JENSEN, ELISABET and OLSSON, HÅKAN},
  issn         = {0903-4641},
  keyword      = {Breast carcinoma,immunohistochemistry,neuroendocrine differentiation},
  language     = {eng},
  month        = {01},
  number       = {7-12},
  pages        = {720--726},
  publisher    = {John Wiley & Sons},
  series       = {APMIS1988-01-01+01:00},
  title        = {Neuroendocrine differentiation in male breast carcinomas},
  url          = {http://dx.doi.org/10.1111/j.1699-0463.1992.tb03990.x},
  volume       = {100},
  year         = {1992},
}