Effects of FK506 on regeneration and macrophages in injured rat sciatic nerve.
Kvist, Martin LU ; Danielsen, Nils LU and Dahlin, Lars LU
(2003)
In Journal of the Peripheral Nervous System
8(4).
p.251-259
- Abstract
- Effects of FK506 [5.0 mg/kg body weight (BW), subcutaneous, daily] on nerve regeneration and presence of macrophages in lesioned rat sciatic nerves were studied. Models of autologous nerve graft or a nerve crush lesion were used and regeneration was evaluated by immunocytochemistry (also used to detect ED1/ED2 macrophages) and sensory pinch reflex test, respectively. Treatment with FK506 did not increase regeneration distance or regeneration rate in the autologous nerve grafts. However, regeneration distances after nerve crush were significantly longer following treatment with FK506. The number of macrophages (ED1/ED2) in nerve grafts increased over time, but treatment with FK506 had limited effects only in the presence of ED2 macrophages.... (More)
- Effects of FK506 [5.0 mg/kg body weight (BW), subcutaneous, daily] on nerve regeneration and presence of macrophages in lesioned rat sciatic nerves were studied. Models of autologous nerve graft or a nerve crush lesion were used and regeneration was evaluated by immunocytochemistry (also used to detect ED1/ED2 macrophages) and sensory pinch reflex test, respectively. Treatment with FK506 did not increase regeneration distance or regeneration rate in the autologous nerve grafts. However, regeneration distances after nerve crush were significantly longer following treatment with FK506. The number of macrophages (ED1/ED2) in nerve grafts increased over time, but treatment with FK506 had limited effects only in the presence of ED2 macrophages. Present and previously published studies may imply that there is a time-related and type-of-injury-related profile of FK506's pro-regenerative effect. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/119877
- author
- Kvist, Martin
LU
; Danielsen, Nils
LU
and Dahlin, Lars
LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of the Peripheral Nervous System
- volume
- 8
- issue
- 4
- pages
- 251 - 259
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000187429300007
- pmid:14641649
- scopus:0346093573
- ISSN
- 1085-9489
- DOI
- 10.1111/j.1085-9489.2003.03021.x
- project
- Nerve regeneration - signal transduktion mechanisms, timing and alternatives to nerve grafts
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hand Surgery Research Group (013241910), Neural Interfaces (013212003), Reconstructive Surgery (013240300)
- id
- c2d32ab0-408c-4fa0-8dd2-47bd5791ab63 (old id 119877)
- date added to LUP
- 2016-04-01 16:00:10
- date last changed
- 2022-01-28 08:38:50
@article{c2d32ab0-408c-4fa0-8dd2-47bd5791ab63,
abstract = {{Effects of FK506 [5.0 mg/kg body weight (BW), subcutaneous, daily] on nerve regeneration and presence of macrophages in lesioned rat sciatic nerves were studied. Models of autologous nerve graft or a nerve crush lesion were used and regeneration was evaluated by immunocytochemistry (also used to detect ED1/ED2 macrophages) and sensory pinch reflex test, respectively. Treatment with FK506 did not increase regeneration distance or regeneration rate in the autologous nerve grafts. However, regeneration distances after nerve crush were significantly longer following treatment with FK506. The number of macrophages (ED1/ED2) in nerve grafts increased over time, but treatment with FK506 had limited effects only in the presence of ED2 macrophages. Present and previously published studies may imply that there is a time-related and type-of-injury-related profile of FK506's pro-regenerative effect.}},
author = {{Kvist, Martin and Danielsen, Nils and Dahlin, Lars}},
issn = {{1085-9489}},
language = {{eng}},
number = {{4}},
pages = {{251--259}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of the Peripheral Nervous System}},
title = {{Effects of FK506 on regeneration and macrophages in injured rat sciatic nerve.}},
url = {{https://lup.lub.lu.se/search/files/4540004/623928.pdf}},
doi = {{10.1111/j.1085-9489.2003.03021.x}},
volume = {{8}},
year = {{2003}},
}