Neuronal replacement from endogenous precursors in the adult brain after stroke.
Arvidsson, Andreas LU ; Collin, Tove LU ; Kirik, Deniz LU ; Kokaia, Zaal LU
and Lindvall, Olle
LU
(2002)
In Nature Medicine
8(9).
p.963-970
- Abstract
- In the adult brain, new neurons are continuously generated in the subventricular zone and dentate gyrus, but it is unknown whether these neurons can replace those lost following damage or disease. Here we show that stroke, caused by transient middle cerebral artery occlusion in adult rats, leads to a marked increase of cell proliferation in the subventricular zone. Stroke-generated new neurons, as well as neuroblasts probably already formed before the insult, migrate into the severely damaged area of the striatum, where they express markers of developing and mature, striatal medium-sized spiny neurons. Thus, stroke induces differentiation of new neurons into the phenotype of most of the neurons destroyed by the ischemic lesion. Here we... (More)
- In the adult brain, new neurons are continuously generated in the subventricular zone and dentate gyrus, but it is unknown whether these neurons can replace those lost following damage or disease. Here we show that stroke, caused by transient middle cerebral artery occlusion in adult rats, leads to a marked increase of cell proliferation in the subventricular zone. Stroke-generated new neurons, as well as neuroblasts probably already formed before the insult, migrate into the severely damaged area of the striatum, where they express markers of developing and mature, striatal medium-sized spiny neurons. Thus, stroke induces differentiation of new neurons into the phenotype of most of the neurons destroyed by the ischemic lesion. Here we show that the adult brain has the capacity for self-repair after insults causing extensive neuronal death. If the new neurons are functional and their formation can be stimulated, a novel therapeutic strategy might be developed for stroke in humans. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/109740
- author
- Arvidsson, Andreas
LU
; Collin, Tove
LU
; Kirik, Deniz
LU
; Kokaia, Zaal
LU
and Lindvall, Olle
LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Medicine
- volume
- 8
- issue
- 9
- pages
- 963 - 970
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:12161747
- wos:000177757900031
- scopus:0036735672
- ISSN
- 1546-170X
- DOI
- 10.1038/nm747
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Restorative Neurology (0131000160), Neurobiology (013212024), Brain Repair and Imaging in Neural Systems (BRAINS) (013212027), Neurology, Lund (013027000)
- id
- c3087779-d5a3-493f-9bb1-91bbc8b08a98 (old id 109740)
- alternative location
- http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12161747&dopt=Abstract
- date added to LUP
- 2016-04-01 16:41:08
- date last changed
- 2022-04-22 23:29:01
@article{c3087779-d5a3-493f-9bb1-91bbc8b08a98,
abstract = {{In the adult brain, new neurons are continuously generated in the subventricular zone and dentate gyrus, but it is unknown whether these neurons can replace those lost following damage or disease. Here we show that stroke, caused by transient middle cerebral artery occlusion in adult rats, leads to a marked increase of cell proliferation in the subventricular zone. Stroke-generated new neurons, as well as neuroblasts probably already formed before the insult, migrate into the severely damaged area of the striatum, where they express markers of developing and mature, striatal medium-sized spiny neurons. Thus, stroke induces differentiation of new neurons into the phenotype of most of the neurons destroyed by the ischemic lesion. Here we show that the adult brain has the capacity for self-repair after insults causing extensive neuronal death. If the new neurons are functional and their formation can be stimulated, a novel therapeutic strategy might be developed for stroke in humans.}},
author = {{Arvidsson, Andreas and Collin, Tove and Kirik, Deniz and Kokaia, Zaal and Lindvall, Olle}},
issn = {{1546-170X}},
language = {{eng}},
number = {{9}},
pages = {{963--970}},
publisher = {{Nature Publishing Group}},
series = {{Nature Medicine}},
title = {{Neuronal replacement from endogenous precursors in the adult brain after stroke.}},
url = {{https://lup.lub.lu.se/search/files/4749661/623641.pdf}},
doi = {{10.1038/nm747}},
volume = {{8}},
year = {{2002}},
}