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Rate differences between first and second primary cancers may outline immune dysfunction as a key risk factor

Zheng, Guoqiao LU ; Sundquist, Kristina LU ; Sundquist, Jan LU ; Försti, Asta LU ; Hemminki, Akseli and Hemminki, Kari LU (2020) In Cancer Medicine 9(21). p.8258-8265
Abstract

Background: Many cancers are increased in immunosuppressed patients and evidence is accumulating that immune dysfunction may be a contributing risk factor for second primary cancers (SPCs). The aim of this study was to explore the potential influence of immune mechanisms in SPC. Methods: We used the Swedish Cancer Registry (1990-2015) to select 13 male and 14 female first primary cancers (FPCs) that are known to be related to immune suppression. We assessed relative risks (RRs) for any of these as concordant (same first and second cancer) and discordant FPC-SPC pairs. Hierarchical clustering of significant RRs was performed for cancers as FPC and SPC. Results: Concordant risks for SPCs were excessive in men and women for nasal (RRs 59.3... (More)

Background: Many cancers are increased in immunosuppressed patients and evidence is accumulating that immune dysfunction may be a contributing risk factor for second primary cancers (SPCs). The aim of this study was to explore the potential influence of immune mechanisms in SPC. Methods: We used the Swedish Cancer Registry (1990-2015) to select 13 male and 14 female first primary cancers (FPCs) that are known to be related to immune suppression. We assessed relative risks (RRs) for any of these as concordant (same first and second cancer) and discordant FPC-SPC pairs. Hierarchical clustering of significant RRs was performed for cancers as FPC and SPC. Results: Concordant risks for SPCs were excessive in men and women for nasal (RRs 59.3 for men and 150.6 for women), tongue/mouth (51.7 and 100.8), and lip (32.4 and 61.2) cancers. Heatmaps showed that some cancers, such as skin cancer, tongue/mouth cancers, and non-Hodgkin lymphoma had multiple bidirectional associations as FPC and SPC. Nasal cancer and chronic lymphocytic leukemia had associations mainly as FPC while liver and kidney cancers showed most associations as SPC. Conclusions: Immune dysfunction may be a plausible contributing factor for most of the associations, which calls for experimental verification.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cancer risk, immune suppression, multiple cancers, risk factors
in
Cancer Medicine
volume
9
issue
21
pages
8 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:32960498
  • scopus:85091317841
ISSN
2045-7634
DOI
10.1002/cam4.3454
language
English
LU publication?
yes
id
c34bf3e4-6e72-4f55-8a37-137093dad68f
date added to LUP
2020-11-02 09:43:53
date last changed
2024-04-03 15:44:16
@article{c34bf3e4-6e72-4f55-8a37-137093dad68f,
  abstract     = {{<p>Background: Many cancers are increased in immunosuppressed patients and evidence is accumulating that immune dysfunction may be a contributing risk factor for second primary cancers (SPCs). The aim of this study was to explore the potential influence of immune mechanisms in SPC. Methods: We used the Swedish Cancer Registry (1990-2015) to select 13 male and 14 female first primary cancers (FPCs) that are known to be related to immune suppression. We assessed relative risks (RRs) for any of these as concordant (same first and second cancer) and discordant FPC-SPC pairs. Hierarchical clustering of significant RRs was performed for cancers as FPC and SPC. Results: Concordant risks for SPCs were excessive in men and women for nasal (RRs 59.3 for men and 150.6 for women), tongue/mouth (51.7 and 100.8), and lip (32.4 and 61.2) cancers. Heatmaps showed that some cancers, such as skin cancer, tongue/mouth cancers, and non-Hodgkin lymphoma had multiple bidirectional associations as FPC and SPC. Nasal cancer and chronic lymphocytic leukemia had associations mainly as FPC while liver and kidney cancers showed most associations as SPC. Conclusions: Immune dysfunction may be a plausible contributing factor for most of the associations, which calls for experimental verification.</p>}},
  author       = {{Zheng, Guoqiao and Sundquist, Kristina and Sundquist, Jan and Försti, Asta and Hemminki, Akseli and Hemminki, Kari}},
  issn         = {{2045-7634}},
  keywords     = {{cancer risk; immune suppression; multiple cancers; risk factors}},
  language     = {{eng}},
  number       = {{21}},
  pages        = {{8258--8265}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Cancer Medicine}},
  title        = {{Rate differences between first and second primary cancers may outline immune dysfunction as a key risk factor}},
  url          = {{http://dx.doi.org/10.1002/cam4.3454}},
  doi          = {{10.1002/cam4.3454}},
  volume       = {{9}},
  year         = {{2020}},
}