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Selective enhancement of synthesis of interleukin-2 in lymphocytes in the presence of ciprofloxacin

Riesbeck, K. LU and Forsgren, A. LU (1990) In European Journal of Clinical Microbiology & Infectious Diseases 9(6). p.409-413
Abstract

A study was performed to verify the effect of ciprofloxacin on the production of interleukin-2 and other cytokines in cultures of human peripheral lymphocytes. In the presence of ciprofloxacin, lymphocytes demonstrated increased synthesis of interleukin-2 (100-fold, 7-fold and 1.5-fold increase at ciprofloxacin concentrations of 80, 20 and 5 μg/ml respectively), as measured by radioimmunoassay. Synthesis of other cytokines from T lymphocytes, gamma-interferon, lymphotoxin and granulocyte-macrophage colony stimulating factor as well as interleukin-1 and tumour necrosis factor from monocytes was not increased, but inhibited at a ciprofloxacin concentration of 80 μg/ml. Thus the effect of ciprofloxacin resulting in enhanced synthesis of... (More)

A study was performed to verify the effect of ciprofloxacin on the production of interleukin-2 and other cytokines in cultures of human peripheral lymphocytes. In the presence of ciprofloxacin, lymphocytes demonstrated increased synthesis of interleukin-2 (100-fold, 7-fold and 1.5-fold increase at ciprofloxacin concentrations of 80, 20 and 5 μg/ml respectively), as measured by radioimmunoassay. Synthesis of other cytokines from T lymphocytes, gamma-interferon, lymphotoxin and granulocyte-macrophage colony stimulating factor as well as interleukin-1 and tumour necrosis factor from monocytes was not increased, but inhibited at a ciprofloxacin concentration of 80 μg/ml. Thus the effect of ciprofloxacin resulting in enhanced synthesis of interleukin-2 seems to be specific.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Clinical Microbiology & Infectious Diseases
volume
9
issue
6
pages
409 - 413
publisher
Springer
external identifiers
  • scopus:0025280424
ISSN
0934-9723
DOI
10.1007/BF01979471
language
English
LU publication?
yes
id
c351f9da-66cf-45f8-9da9-5c4c4e88c4e2
date added to LUP
2019-03-27 14:25:52
date last changed
2019-06-08 02:20:13
@article{c351f9da-66cf-45f8-9da9-5c4c4e88c4e2,
  abstract     = {<p>A study was performed to verify the effect of ciprofloxacin on the production of interleukin-2 and other cytokines in cultures of human peripheral lymphocytes. In the presence of ciprofloxacin, lymphocytes demonstrated increased synthesis of interleukin-2 (100-fold, 7-fold and 1.5-fold increase at ciprofloxacin concentrations of 80, 20 and 5 μg/ml respectively), as measured by radioimmunoassay. Synthesis of other cytokines from T lymphocytes, gamma-interferon, lymphotoxin and granulocyte-macrophage colony stimulating factor as well as interleukin-1 and tumour necrosis factor from monocytes was not increased, but inhibited at a ciprofloxacin concentration of 80 μg/ml. Thus the effect of ciprofloxacin resulting in enhanced synthesis of interleukin-2 seems to be specific.</p>},
  author       = {Riesbeck, K. and Forsgren, A.},
  issn         = {0934-9723},
  language     = {eng},
  month        = {06},
  number       = {6},
  pages        = {409--413},
  publisher    = {Springer},
  series       = {European Journal of Clinical Microbiology & Infectious Diseases},
  title        = {Selective enhancement of synthesis of interleukin-2 in lymphocytes in the presence of ciprofloxacin},
  url          = {http://dx.doi.org/10.1007/BF01979471},
  volume       = {9},
  year         = {1990},
}