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Selective enhancement of synthesis of interleukin-2 in lymphocytes in the presence of ciprofloxacin

Riesbeck, K. LU orcid and Forsgren, A. LU (1990) In European Journal of Clinical Microbiology & Infectious Diseases 9(6). p.409-413
Abstract

A study was performed to verify the effect of ciprofloxacin on the production of interleukin-2 and other cytokines in cultures of human peripheral lymphocytes. In the presence of ciprofloxacin, lymphocytes demonstrated increased synthesis of interleukin-2 (100-fold, 7-fold and 1.5-fold increase at ciprofloxacin concentrations of 80, 20 and 5 μg/ml respectively), as measured by radioimmunoassay. Synthesis of other cytokines from T lymphocytes, gamma-interferon, lymphotoxin and granulocyte-macrophage colony stimulating factor as well as interleukin-1 and tumour necrosis factor from monocytes was not increased, but inhibited at a ciprofloxacin concentration of 80 μg/ml. Thus the effect of ciprofloxacin resulting in enhanced synthesis of... (More)

A study was performed to verify the effect of ciprofloxacin on the production of interleukin-2 and other cytokines in cultures of human peripheral lymphocytes. In the presence of ciprofloxacin, lymphocytes demonstrated increased synthesis of interleukin-2 (100-fold, 7-fold and 1.5-fold increase at ciprofloxacin concentrations of 80, 20 and 5 μg/ml respectively), as measured by radioimmunoassay. Synthesis of other cytokines from T lymphocytes, gamma-interferon, lymphotoxin and granulocyte-macrophage colony stimulating factor as well as interleukin-1 and tumour necrosis factor from monocytes was not increased, but inhibited at a ciprofloxacin concentration of 80 μg/ml. Thus the effect of ciprofloxacin resulting in enhanced synthesis of interleukin-2 seems to be specific.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Clinical Microbiology & Infectious Diseases
volume
9
issue
6
pages
409 - 413
publisher
Springer Science and Business Media B.V.
external identifiers
  • scopus:0025280424
  • pmid:2117532
ISSN
0934-9723
DOI
10.1007/BF01979471
language
English
LU publication?
yes
id
c351f9da-66cf-45f8-9da9-5c4c4e88c4e2
date added to LUP
2019-03-27 14:25:52
date last changed
2025-10-14 13:14:33
@article{c351f9da-66cf-45f8-9da9-5c4c4e88c4e2,
  abstract     = {{<p>A study was performed to verify the effect of ciprofloxacin on the production of interleukin-2 and other cytokines in cultures of human peripheral lymphocytes. In the presence of ciprofloxacin, lymphocytes demonstrated increased synthesis of interleukin-2 (100-fold, 7-fold and 1.5-fold increase at ciprofloxacin concentrations of 80, 20 and 5 μg/ml respectively), as measured by radioimmunoassay. Synthesis of other cytokines from T lymphocytes, gamma-interferon, lymphotoxin and granulocyte-macrophage colony stimulating factor as well as interleukin-1 and tumour necrosis factor from monocytes was not increased, but inhibited at a ciprofloxacin concentration of 80 μg/ml. Thus the effect of ciprofloxacin resulting in enhanced synthesis of interleukin-2 seems to be specific.</p>}},
  author       = {{Riesbeck, K. and Forsgren, A.}},
  issn         = {{0934-9723}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{6}},
  pages        = {{409--413}},
  publisher    = {{Springer Science and Business Media B.V.}},
  series       = {{European Journal of Clinical Microbiology & Infectious Diseases}},
  title        = {{Selective enhancement of synthesis of interleukin-2 in lymphocytes in the presence of ciprofloxacin}},
  url          = {{http://dx.doi.org/10.1007/BF01979471}},
  doi          = {{10.1007/BF01979471}},
  volume       = {{9}},
  year         = {{1990}},
}