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Connecting Cohorts to Diminish Alzheimer's Disease (CONCORD-AD) : A Report of an International Research Collaboration Network

Pavlik, Valory N. ; Burnham, Samantha C. ; Kass, Joseph S. ; Helmer, Catherine ; Palmqvist, Sebastian LU orcid ; Vassilaki, Maria ; Dartigues, Jean François ; Hansson, Oskar LU orcid ; Masters, Colin L. and Pérès, Karine , et al. (2022) In Journal of Alzheimer's Disease 85(1). p.31-45
Abstract

Longitudinal observational cohort studies are being conducted worldwide to understand cognition, biomarkers, and the health of the aging population better. Cross-cohort comparisons and networks of registries in Alzheimer's disease (AD) foster scientific exchange, generate insights, and contribute to the evolving clinical science in AD. A scientific working group was convened with invited investigators from established cohort studies in AD, in order to form a research collaboration network as a resource to address important research questions. The Connecting Cohorts to Diminish Alzheimer's Disease (CONCORD-AD) collaboration network was created to bring together global resources and expertise, to generate insights and improve... (More)

Longitudinal observational cohort studies are being conducted worldwide to understand cognition, biomarkers, and the health of the aging population better. Cross-cohort comparisons and networks of registries in Alzheimer's disease (AD) foster scientific exchange, generate insights, and contribute to the evolving clinical science in AD. A scientific working group was convened with invited investigators from established cohort studies in AD, in order to form a research collaboration network as a resource to address important research questions. The Connecting Cohorts to Diminish Alzheimer's Disease (CONCORD-AD) collaboration network was created to bring together global resources and expertise, to generate insights and improve understanding of the natural history of AD, to inform design of clinical trials in all disease stages, and to plan for optimal patient access to disease-modifying therapies once they become available. The network brings together expertise and data insights from 7 cohorts across Australia, Europe, and North America. Notably, the network includes populations recruited through memory clinics as well as population-based cohorts, representing observations from individuals across the AD spectrum. This report aims to introduce the CONCORD-AD network, providing an overview of the cohorts involved, reporting the common assessments used, and describing the key characteristics of the cohort populations. Cohort study designs and baseline population characteristics are compared, and available cognitive, functional, and neuropsychiatric symptom data, as well as the frequency of biomarker assessments, are summarized. Finally, the challenges and opportunities of cross-cohort studies in AD are discussed.

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@article{c47ca5bd-8df8-4a35-912b-e6f73ed40289,
  abstract     = {{<p>Longitudinal observational cohort studies are being conducted worldwide to understand cognition, biomarkers, and the health of the aging population better. Cross-cohort comparisons and networks of registries in Alzheimer's disease (AD) foster scientific exchange, generate insights, and contribute to the evolving clinical science in AD. A scientific working group was convened with invited investigators from established cohort studies in AD, in order to form a research collaboration network as a resource to address important research questions. The Connecting Cohorts to Diminish Alzheimer's Disease (CONCORD-AD) collaboration network was created to bring together global resources and expertise, to generate insights and improve understanding of the natural history of AD, to inform design of clinical trials in all disease stages, and to plan for optimal patient access to disease-modifying therapies once they become available. The network brings together expertise and data insights from 7 cohorts across Australia, Europe, and North America. Notably, the network includes populations recruited through memory clinics as well as population-based cohorts, representing observations from individuals across the AD spectrum. This report aims to introduce the CONCORD-AD network, providing an overview of the cohorts involved, reporting the common assessments used, and describing the key characteristics of the cohort populations. Cohort study designs and baseline population characteristics are compared, and available cognitive, functional, and neuropsychiatric symptom data, as well as the frequency of biomarker assessments, are summarized. Finally, the challenges and opportunities of cross-cohort studies in AD are discussed.</p>}},
  author       = {{Pavlik, Valory N. and Burnham, Samantha C. and Kass, Joseph S. and Helmer, Catherine and Palmqvist, Sebastian and Vassilaki, Maria and Dartigues, Jean François and Hansson, Oskar and Masters, Colin L. and Pérès, Karine and Petersen, Ronald C. and Stomrud, Erik and Butler, Lesley and Coloma, Preciosa M. and Teitsma, Xavier M. and Doody, Rachelle and Sano, Mary}},
  issn         = {{1387-2877}},
  keywords     = {{Alzheimer's disease; biomarkers; cognitive function; cohort; CONCORD-AD network; dementia; observational study; population characteristics}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{31--45}},
  publisher    = {{IOS Press}},
  series       = {{Journal of Alzheimer's Disease}},
  title        = {{Connecting Cohorts to Diminish Alzheimer's Disease (CONCORD-AD) : A Report of an International Research Collaboration Network}},
  url          = {{http://dx.doi.org/10.3233/jad-210525}},
  doi          = {{10.3233/jad-210525}},
  volume       = {{85}},
  year         = {{2022}},
}