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BDNF makes cultured dentate granule cells more resistant to hypoglycemic damage

Kokaia, Zaal LU orcid ; SanMartin, Agneta LU ; Kokaia, Merab LU and Lindvall, Olle LU (1994) In NeuroReport 5(10). p.1241-1244
Abstract
THE aim of this study was to explore whether brain-derived neurotrophic factor (BDNF) can improve neuronal survival in cell cultures of rat dentate gyrus subjected to a hypoglycaemic insult. Glucose deprivation for 15 h caused severe neuronal loss (about 70%). BDNF added either 24 h before or 4 h after onset of hypoglycaemia completely protected granule cells against this insult-induced damage. Nerve growth factor (NGF) had similar effects. These findings support the hypothesis that the rapid upregulation of BDNF mRNA in dentate granule cells after brief periods of hypoglycaemic coma and other insults is a local protective mechanism.
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hypoglycaemia, Dentate gyrus, Neurotrophins, Neuronal protection, Brain insults
in
NeuroReport
volume
5
issue
10
pages
1241 - 1244
publisher
Lippincott Williams & Wilkins
ISSN
1473-558X
DOI
10.1097/00001756-199406020-00021
language
English
LU publication?
yes
additional info
Author Othberg was 1991-1996 an employee at Restorative Neurology Unit research group led by Lindvall.
id
c48ac862-34aa-49f5-b76f-fdb5e6728733 (old id 4025354)
date added to LUP
2016-04-04 08:55:33
date last changed
2021-09-27 05:53:22
@article{c48ac862-34aa-49f5-b76f-fdb5e6728733,
  abstract     = {{THE aim of this study was to explore whether brain-derived neurotrophic factor (BDNF) can improve neuronal survival in cell cultures of rat dentate gyrus subjected to a hypoglycaemic insult. Glucose deprivation for 15 h caused severe neuronal loss (about 70%). BDNF added either 24 h before or 4 h after onset of hypoglycaemia completely protected granule cells against this insult-induced damage. Nerve growth factor (NGF) had similar effects. These findings support the hypothesis that the rapid upregulation of BDNF mRNA in dentate granule cells after brief periods of hypoglycaemic coma and other insults is a local protective mechanism.}},
  author       = {{Kokaia, Zaal and SanMartin, Agneta and Kokaia, Merab and Lindvall, Olle}},
  issn         = {{1473-558X}},
  keywords     = {{Hypoglycaemia; Dentate gyrus; Neurotrophins; Neuronal protection; Brain insults}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1241--1244}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{NeuroReport}},
  title        = {{BDNF makes cultured dentate granule cells more resistant to hypoglycemic damage}},
  url          = {{http://dx.doi.org/10.1097/00001756-199406020-00021}},
  doi          = {{10.1097/00001756-199406020-00021}},
  volume       = {{5}},
  year         = {{1994}},
}