Bioavailability and interactions of schisandrin B with 5-fluorouracil in a xenograft mouse model of colorectal cancer
(2025) In Food Chemistry 463.- Abstract
Schisandrin B (Sch B) is a predominant bioactive lignan from the fruit of a Chinese medicine food homology plant, Schisandra chinensis. Previously, we observed potent anti-tumor effect of Sch-B in colorectal cancer (CRC) and enhanced chemotherapy efficacy with fluorouracil (5-FU). However, their bioavailability and reciprocal interactions under CRC conditions are unclear. In this study, we first compared the bioavailability, metabolism and tissue distribution of Sch-B between non-tumor-bearing and xenograft CRC tumor-bearing mice. Next, we examined SchB-5-FU interactions via investigating alterations in drug metabolism and multidrug resistance. Using a validated targeted metabolomics approach, five active metabolites, including Sch-B... (More)
Schisandrin B (Sch B) is a predominant bioactive lignan from the fruit of a Chinese medicine food homology plant, Schisandra chinensis. Previously, we observed potent anti-tumor effect of Sch-B in colorectal cancer (CRC) and enhanced chemotherapy efficacy with fluorouracil (5-FU). However, their bioavailability and reciprocal interactions under CRC conditions are unclear. In this study, we first compared the bioavailability, metabolism and tissue distribution of Sch-B between non-tumor-bearing and xenograft CRC tumor-bearing mice. Next, we examined SchB-5-FU interactions via investigating alterations in drug metabolism and multidrug resistance. Using a validated targeted metabolomics approach, five active metabolites, including Sch-B and fluorodeoxyuridine triphosphate, were found tumor-accumulative. Co-treatment resulted in higher levels of Sch-B and 5-FU metabolites, showing improved phytochemical and drug bioavailability. Multidrug resistance gene (MDR1) was significantly downregulated upon co-treatment. Overall, we demonstrated the potential of Sch-B to serve as a promising chemotherapy adjuvant via improving drug bioavailability and metabolism, and attenuating MDR.
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- author
- Lee, Pui Kei ; Co, Vanessa Anna ; Yang, Yang ; Wan, Murphy Lam Yim LU ; El-Nezami, Hani and Zhao, Danyue
- organization
- publishing date
- 2025-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bioavailability, Colorectal cancer, Metabolism, Phytochemical-drug interaction, Schisandrin B, Targeted metabolomics
- in
- Food Chemistry
- volume
- 463
- article number
- 141371
- publisher
- Elsevier
- external identifiers
-
- pmid:39332376
- scopus:85204802129
- ISSN
- 0308-8146
- DOI
- 10.1016/j.foodchem.2024.141371
- language
- English
- LU publication?
- yes
- id
- c5535c40-9fde-4f1e-9758-985cf4e7c8d5
- date added to LUP
- 2024-11-12 15:33:08
- date last changed
- 2025-06-11 08:36:26
@article{c5535c40-9fde-4f1e-9758-985cf4e7c8d5,
abstract = {{<p>Schisandrin B (Sch B) is a predominant bioactive lignan from the fruit of a Chinese medicine food homology plant, Schisandra chinensis. Previously, we observed potent anti-tumor effect of Sch-B in colorectal cancer (CRC) and enhanced chemotherapy efficacy with fluorouracil (5-FU). However, their bioavailability and reciprocal interactions under CRC conditions are unclear. In this study, we first compared the bioavailability, metabolism and tissue distribution of Sch-B between non-tumor-bearing and xenograft CRC tumor-bearing mice. Next, we examined SchB-5-FU interactions via investigating alterations in drug metabolism and multidrug resistance. Using a validated targeted metabolomics approach, five active metabolites, including Sch-B and fluorodeoxyuridine triphosphate, were found tumor-accumulative. Co-treatment resulted in higher levels of Sch-B and 5-FU metabolites, showing improved phytochemical and drug bioavailability. Multidrug resistance gene (MDR1) was significantly downregulated upon co-treatment. Overall, we demonstrated the potential of Sch-B to serve as a promising chemotherapy adjuvant via improving drug bioavailability and metabolism, and attenuating MDR.</p>}},
author = {{Lee, Pui Kei and Co, Vanessa Anna and Yang, Yang and Wan, Murphy Lam Yim and El-Nezami, Hani and Zhao, Danyue}},
issn = {{0308-8146}},
keywords = {{Bioavailability; Colorectal cancer; Metabolism; Phytochemical-drug interaction; Schisandrin B; Targeted metabolomics}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Food Chemistry}},
title = {{Bioavailability and interactions of schisandrin B with 5-fluorouracil in a xenograft mouse model of colorectal cancer}},
url = {{http://dx.doi.org/10.1016/j.foodchem.2024.141371}},
doi = {{10.1016/j.foodchem.2024.141371}},
volume = {{463}},
year = {{2025}},
}