Advanced

Deciphering systemic lupus erythematosus-associated serum biomarkers reflecting apoptosis and disease activity

Delfani, P. LU ; Sturfelt, G. LU ; Gullstrand, B. LU ; Carlsson, A. LU ; Kassandra, M.; Borrebaeck, C. A K LU ; Bengtsson, A. A. LU and Wingren, C. LU (2017) In Lupus 26(4). p.373-387
Abstract

Systemic lupus erythematosus (SLE) is a severe chronic inflammatory autoimmune connective tissue disease. Despite major efforts, SLE remains a poorly understood disease with unpredictable course, unknown etiology and complex pathogenesis. Apoptosis combined with deficiency in clearing apoptotic cells is an important etiopathogenic event in SLE, which could contribute to the increased load of potential autoantigen(s); however, the lack of disease-specific protein signatures deciphering SLE and the underlying biological processes is striking and represents a key limitation. In this retrospective pilot study, we explored the immune system as a specific sensor for disease, in order to advance our understanding of SLE. To this end, we... (More)

Systemic lupus erythematosus (SLE) is a severe chronic inflammatory autoimmune connective tissue disease. Despite major efforts, SLE remains a poorly understood disease with unpredictable course, unknown etiology and complex pathogenesis. Apoptosis combined with deficiency in clearing apoptotic cells is an important etiopathogenic event in SLE, which could contribute to the increased load of potential autoantigen(s); however, the lack of disease-specific protein signatures deciphering SLE and the underlying biological processes is striking and represents a key limitation. In this retrospective pilot study, we explored the immune system as a specific sensor for disease, in order to advance our understanding of SLE. To this end, we determined multiplexed serum protein expression profiles of crude SLE serum samples, using antibody microarrays. The aim was to identify differential immunoprofiles, or snapshots of the immune response modulated by the disease, reflecting apoptosis, a key process in the etiology of SLE and disease activity. The results showed that multiplexed panels of SLE-associated serum biomarkers could be decoded, in particular reflecting disease activity, but potentially the apoptosis process as well. While the former biomarkers could display a potential future use for prognosis, the latter biomarkers might help shed further light on the apoptosis process taking place in SLE.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antibody microarray, apoptosis, autoantibodies, biomarker, disease activity, systemic lupus erythematosus
in
Lupus
volume
26
issue
4
pages
15 pages
publisher
SAGE Publications Ltd
external identifiers
  • scopus:85015734898
  • wos:000397488800005
ISSN
0961-2033
DOI
10.1177/0961203316669240
language
English
LU publication?
yes
id
c58b9008-94c0-4125-93e6-d2be3f93207c
date added to LUP
2017-04-26 14:07:48
date last changed
2018-01-07 12:01:01
@article{c58b9008-94c0-4125-93e6-d2be3f93207c,
  abstract     = {<p>Systemic lupus erythematosus (SLE) is a severe chronic inflammatory autoimmune connective tissue disease. Despite major efforts, SLE remains a poorly understood disease with unpredictable course, unknown etiology and complex pathogenesis. Apoptosis combined with deficiency in clearing apoptotic cells is an important etiopathogenic event in SLE, which could contribute to the increased load of potential autoantigen(s); however, the lack of disease-specific protein signatures deciphering SLE and the underlying biological processes is striking and represents a key limitation. In this retrospective pilot study, we explored the immune system as a specific sensor for disease, in order to advance our understanding of SLE. To this end, we determined multiplexed serum protein expression profiles of crude SLE serum samples, using antibody microarrays. The aim was to identify differential immunoprofiles, or snapshots of the immune response modulated by the disease, reflecting apoptosis, a key process in the etiology of SLE and disease activity. The results showed that multiplexed panels of SLE-associated serum biomarkers could be decoded, in particular reflecting disease activity, but potentially the apoptosis process as well. While the former biomarkers could display a potential future use for prognosis, the latter biomarkers might help shed further light on the apoptosis process taking place in SLE.</p>},
  author       = {Delfani, P. and Sturfelt, G. and Gullstrand, B. and Carlsson, A. and Kassandra, M. and Borrebaeck, C. A K and Bengtsson, A. A. and Wingren, C.},
  issn         = {0961-2033},
  keyword      = {Antibody microarray,apoptosis,autoantibodies,biomarker,disease activity,systemic lupus erythematosus},
  language     = {eng},
  month        = {04},
  number       = {4},
  pages        = {373--387},
  publisher    = {SAGE Publications Ltd},
  series       = {Lupus},
  title        = {Deciphering systemic lupus erythematosus-associated serum biomarkers reflecting apoptosis and disease activity},
  url          = {http://dx.doi.org/10.1177/0961203316669240},
  volume       = {26},
  year         = {2017},
}