Continuous Flow Catalytic Reductive Amination of Carbonyl Compounds to Primary Amines with Carbon‐Coated Co@CS Catalyst under Mild Conditions
Mi, Siyi ; Liu, Yulong ; Liu, Jianguo and Pyo, Sang-Hyun LU
(2025)
In ChemPlusChem
90(12).
- Abstract
- Reductive amination is crucial for synthesizing amines in pharmaceutical and industry, yet selectively producing primary amines on a large scale remains challenging. This work presents a continuous-flow reductive amination process using benzaldehyde with NH3 and H2 as the nitrogen sources and reductant. A cobalt catalyst supported on nitrogen-doped carbon derived from chitosan (Co@CS) was developed. After optimization, a primary amine yield exceeding 99% was achieved under mild reaction conditions. The catalyst demonstrated excellent stability in long-term tests and with various substrates, including the biomass lignin-derived vanillin. Compared to batch reactors, theflow reactor provided superior selectivity. This... (More)
- Reductive amination is crucial for synthesizing amines in pharmaceutical and industry, yet selectively producing primary amines on a large scale remains challenging. This work presents a continuous-flow reductive amination process using benzaldehyde with NH3 and H2 as the nitrogen sources and reductant. A cobalt catalyst supported on nitrogen-doped carbon derived from chitosan (Co@CS) was developed. After optimization, a primary amine yield exceeding 99% was achieved under mild reaction conditions. The catalyst demonstrated excellent stability in long-term tests and with various substrates, including the biomass lignin-derived vanillin. Compared to batch reactors, theflow reactor provided superior selectivity. This catalytic flow process minimizes waste, enhances atom economy, avoids hazardous chemical, and improves energy efficiency. The use of a renewable chitosan feedstock and a safer process aligns with multiple principles of green chemistry. The exceptional heat and mass transfer in the Flow system offers an effective strategy for the large-scale production of primary amines from biomass platform compounds. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/c59fcc00-d639-4d55-be44-4d4faacc1748
- author
- Mi, Siyi
; Liu, Yulong
; Liu, Jianguo
and Pyo, Sang-Hyun
LU
- organization
- publishing date
- 2025-12-10
- type
- Contribution to journal
- publication status
- published
- subject
- in
- ChemPlusChem
- volume
- 90
- issue
- 12
- publisher
- Institute of Organic Chemistry and Biochemistry
- external identifiers
-
- pmid:41166575
- scopus:105020196384
- ISSN
- 2192-6506
- DOI
- 10.1002/cplu.202500381
- language
- English
- LU publication?
- yes
- id
- c59fcc00-d639-4d55-be44-4d4faacc1748
- date added to LUP
- 2025-11-29 15:26:31
- date last changed
- 2025-12-19 16:19:51
@article{c59fcc00-d639-4d55-be44-4d4faacc1748,
abstract = {{Reductive amination is crucial for synthesizing amines in pharmaceutical and industry, yet selectively producing primary amines on a large scale remains challenging. This work presents a continuous-flow reductive amination process using benzaldehyde with NH<sub>3</sub> and H<sub>2</sub> as the nitrogen sources and reductant. A cobalt catalyst supported on nitrogen-doped carbon derived from chitosan (Co@CS) was developed. After optimization, a primary amine yield exceeding 99% was achieved under mild reaction conditions. The catalyst demonstrated excellent stability in long-term tests and with various substrates, including the biomass lignin-derived vanillin. Compared to batch reactors, theflow reactor provided superior selectivity. This catalytic flow process minimizes waste, enhances atom economy, avoids hazardous chemical, and improves energy efficiency. The use of a renewable chitosan feedstock and a safer process aligns with multiple principles of green chemistry. The exceptional heat and mass transfer in the Flow system offers an effective strategy for the large-scale production of primary amines from biomass platform compounds.}},
author = {{Mi, Siyi and Liu, Yulong and Liu, Jianguo and Pyo, Sang-Hyun}},
issn = {{2192-6506}},
language = {{eng}},
month = {{12}},
number = {{12}},
publisher = {{Institute of Organic Chemistry and Biochemistry}},
series = {{ChemPlusChem}},
title = {{Continuous Flow Catalytic Reductive Amination of Carbonyl Compounds to Primary Amines with Carbon‐Coated Co@CS Catalyst under Mild Conditions}},
url = {{http://dx.doi.org/10.1002/cplu.202500381}},
doi = {{10.1002/cplu.202500381}},
volume = {{90}},
year = {{2025}},
}