The impact of geometry, intramural friction, and pressure on the antegrade longitudinal motion of the arterial wall : A phantom and finite element study
Sjöstrand, Sandra LU ; Widerström, Alice ; Svensson, Ingrid LU ; Segers, Patrick ; Erlöv, Tobias LU ; Ahlgren, Åsa Rydén LU
and Cinthio, Magnus
LU
(2023)
In Physiological Reports
11(12).
- Abstract
Longitudinal motion of the carotid arterial wall, as measured with ultrasound, has shown promise as an indicator of vascular health. The underlying mechanisms are however not fully understood. We have found, in in vivo studies, that blood pressure has a strong relation to the antegrade longitudinal displacement in early systole. Further, we have identified that a tapered geometry and the intramural friction in-between two parts of a vessel wall influence the longitudinal displacement. We therefore studied the interaction between pressure, vessel geometry and intramural friction, tapered and straight ultrasound phantoms in a paralleled hydraulic bench study and corresponding numerical models. Profound antegrade longitudinal motion was... (More)
Longitudinal motion of the carotid arterial wall, as measured with ultrasound, has shown promise as an indicator of vascular health. The underlying mechanisms are however not fully understood. We have found, in in vivo studies, that blood pressure has a strong relation to the antegrade longitudinal displacement in early systole. Further, we have identified that a tapered geometry and the intramural friction in-between two parts of a vessel wall influence the longitudinal displacement. We therefore studied the interaction between pressure, vessel geometry and intramural friction, tapered and straight ultrasound phantoms in a paralleled hydraulic bench study and corresponding numerical models. Profound antegrade longitudinal motion was induced in the innermost part of both tapered phantoms and the numerical models, but to a lesser extent when intramural friction was increased in the simulations. Strong correlations (R = 0.82–0.96; p < 1e-3; k = 9.3–14 μm/mmHg) between longitudinal displacement and pulse pressure were found in six of seven regions of interest in tapered phantoms. The motion of the straight phantom and the corresponding numerical model was smaller, on average zero or close to zero. This study demonstrates that tapering of the lumen, low intramural friction, and pressure might be important conducive features to the antegrade longitudinal motion of the arterial wall in vivo.
(Less)
- author
- Sjöstrand, Sandra
LU
; Widerström, Alice
; Svensson, Ingrid
LU
; Segers, Patrick
; Erlöv, Tobias
LU
; Ahlgren, Åsa Rydén
LU
and Cinthio, Magnus
LU
- organization
- publishing date
- 2023-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- artery, finite element modeling, longitudinal displacement, shear stress, ultrasound
- in
- Physiological Reports
- volume
- 11
- issue
- 12
- article number
- e15746
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:37332094
- scopus:85162152000
- ISSN
- 2051-817X
- DOI
- 10.14814/phy2.15746
- language
- English
- LU publication?
- yes
- id
- c5ac3a56-90d7-4ee4-a1d2-ca0f83d44f24
- date added to LUP
- 2023-09-21 11:33:04
- date last changed
- 2024-04-19 01:30:46
@article{c5ac3a56-90d7-4ee4-a1d2-ca0f83d44f24,
abstract = {{<p>Longitudinal motion of the carotid arterial wall, as measured with ultrasound, has shown promise as an indicator of vascular health. The underlying mechanisms are however not fully understood. We have found, in in vivo studies, that blood pressure has a strong relation to the antegrade longitudinal displacement in early systole. Further, we have identified that a tapered geometry and the intramural friction in-between two parts of a vessel wall influence the longitudinal displacement. We therefore studied the interaction between pressure, vessel geometry and intramural friction, tapered and straight ultrasound phantoms in a paralleled hydraulic bench study and corresponding numerical models. Profound antegrade longitudinal motion was induced in the innermost part of both tapered phantoms and the numerical models, but to a lesser extent when intramural friction was increased in the simulations. Strong correlations (R = 0.82–0.96; p < 1e-3; k = 9.3–14 μm/mmHg) between longitudinal displacement and pulse pressure were found in six of seven regions of interest in tapered phantoms. The motion of the straight phantom and the corresponding numerical model was smaller, on average zero or close to zero. This study demonstrates that tapering of the lumen, low intramural friction, and pressure might be important conducive features to the antegrade longitudinal motion of the arterial wall in vivo.</p>}},
author = {{Sjöstrand, Sandra and Widerström, Alice and Svensson, Ingrid and Segers, Patrick and Erlöv, Tobias and Ahlgren, Åsa Rydén and Cinthio, Magnus}},
issn = {{2051-817X}},
keywords = {{artery; finite element modeling; longitudinal displacement; shear stress; ultrasound}},
language = {{eng}},
number = {{12}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Physiological Reports}},
title = {{The impact of geometry, intramural friction, and pressure on the antegrade longitudinal motion of the arterial wall : A phantom and finite element study}},
url = {{http://dx.doi.org/10.14814/phy2.15746}},
doi = {{10.14814/phy2.15746}},
volume = {{11}},
year = {{2023}},
}