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TRIM22 genotype is not associated with markers of disease progression in children with HIV-1 infection

Boswell, Michael T. LU ; Yindom, Louis Marie ; Hameiri-Bowen, Dan ; McHugh, Grace ; Dauya, Ethel ; Bandason, Tsitsi ; Mujuru, Hilda ; Esbjörnsson, Joakim LU orcid ; Ferrand, Rashida A. and Rowland-Jones, Sarah (2021) In AIDS (London, England) 35(15). p.2445-2450
Abstract

OBJECTIVE: Untreated perinatal HIV-1 infection is often associated with rapid disease progression in children with HIV (CWH), characterized by high viral loads and early mortality. TRIM22 is a host restriction factor, which directly inhibits HIV-1 transcription, and its genotype variation is associated with disease progression in adults. We tested the hypothesis that TRIM22 genotype is associated with disease progression in CWH. DESIGN: ART-naive CWH, aged 6-16 years, were recruited from primary care clinics in Harare, Zimbabwe. We performed a candidate gene association study of TRIM22 genotype and haplotypes with markers of disease progression and indicators of advanced disease. METHODS: TRIM22 exons three and four were sequenced by... (More)

OBJECTIVE: Untreated perinatal HIV-1 infection is often associated with rapid disease progression in children with HIV (CWH), characterized by high viral loads and early mortality. TRIM22 is a host restriction factor, which directly inhibits HIV-1 transcription, and its genotype variation is associated with disease progression in adults. We tested the hypothesis that TRIM22 genotype is associated with disease progression in CWH. DESIGN: ART-naive CWH, aged 6-16 years, were recruited from primary care clinics in Harare, Zimbabwe. We performed a candidate gene association study of TRIM22 genotype and haplotypes with markers of disease progression and indicators of advanced disease. METHODS: TRIM22 exons three and four were sequenced by Sanger sequencing and single nucleotide polymorphisms were associated with markers of disease progression (CD4+ T-cell count and HIV viral load) and clinical indicators of advanced HIV disease (presence of stunting and chronic diarrhoea). Associations were tested using multivariate linear and logistic regression models. RESULTS: A total of 241 children, median age 11.4 years, 50% female, were included. Stunting was present in 16% of participants. Five SNPs were analyzed including rs7935564, rs2291842, rs78484876, rs1063303 and rs61735273. The median CD4+ count was 342 (IQR: 195-533) cells/μl and median HIV-1 viral load 34 199 (IQR: 8211-90 662) IU/ml. TRIM22 genotype and haplotypes were not associated with CD4+ T-cell count, HIV-1 viral load, stunting or chronic diarrhoea. CONCLUSION: TRIM22 genotype was not associated with markers of HIV disease progression markers or advanced disease in CWH.

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; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
AIDS (London, England)
volume
35
issue
15
pages
6 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85122528592
  • pmid:34870928
ISSN
1473-5571
DOI
10.1097/QAD.0000000000003053
language
English
LU publication?
yes
id
c6033a61-e01e-477f-852e-e19a4f7213f3
date added to LUP
2022-03-14 14:48:11
date last changed
2024-03-28 03:00:50
@article{c6033a61-e01e-477f-852e-e19a4f7213f3,
  abstract     = {{<p>OBJECTIVE: Untreated perinatal HIV-1 infection is often associated with rapid disease progression in children with HIV (CWH), characterized by high viral loads and early mortality. TRIM22 is a host restriction factor, which directly inhibits HIV-1 transcription, and its genotype variation is associated with disease progression in adults. We tested the hypothesis that TRIM22 genotype is associated with disease progression in CWH. DESIGN: ART-naive CWH, aged 6-16 years, were recruited from primary care clinics in Harare, Zimbabwe. We performed a candidate gene association study of TRIM22 genotype and haplotypes with markers of disease progression and indicators of advanced disease. METHODS: TRIM22 exons three and four were sequenced by Sanger sequencing and single nucleotide polymorphisms were associated with markers of disease progression (CD4+ T-cell count and HIV viral load) and clinical indicators of advanced HIV disease (presence of stunting and chronic diarrhoea). Associations were tested using multivariate linear and logistic regression models. RESULTS: A total of 241 children, median age 11.4 years, 50% female, were included. Stunting was present in 16% of participants. Five SNPs were analyzed including rs7935564, rs2291842, rs78484876, rs1063303 and rs61735273. The median CD4+ count was 342 (IQR: 195-533) cells/μl and median HIV-1 viral load 34 199 (IQR: 8211-90 662) IU/ml. TRIM22 genotype and haplotypes were not associated with CD4+ T-cell count, HIV-1 viral load, stunting or chronic diarrhoea. CONCLUSION: TRIM22 genotype was not associated with markers of HIV disease progression markers or advanced disease in CWH.</p>}},
  author       = {{Boswell, Michael T. and Yindom, Louis Marie and Hameiri-Bowen, Dan and McHugh, Grace and Dauya, Ethel and Bandason, Tsitsi and Mujuru, Hilda and Esbjörnsson, Joakim and Ferrand, Rashida A. and Rowland-Jones, Sarah}},
  issn         = {{1473-5571}},
  language     = {{eng}},
  number       = {{15}},
  pages        = {{2445--2450}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{AIDS (London, England)}},
  title        = {{TRIM22 genotype is not associated with markers of disease progression in children with HIV-1 infection}},
  url          = {{http://dx.doi.org/10.1097/QAD.0000000000003053}},
  doi          = {{10.1097/QAD.0000000000003053}},
  volume       = {{35}},
  year         = {{2021}},
}