Advanced

Dietary Intake of Vitamin D and Calcium and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition

Abbas, Sascha; Linseisen, Jakob; Rohrmann, Sabine; Chang-Claude, Jenny; Peeters, Petra H.; Engel, Pierre; Brustad, Magritt; Lund, Eiliv; Skeie, Guri and Olsen, Anja, et al. (2013) In Nutrition and Cancer 65(2). p.178-187
Abstract
Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for pre- and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95% CI were 1.07 (0.871.32) and... (More)
Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for pre- and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95% CI were 1.07 (0.871.32) and 1.02 (0.901.16) for pre- and postmenopausal women, respectively. The corresponding HR and 95% CIs for calcium intake were 0.98 (0.801.19) and 0.90 (0.791.02), respectively. For calcium intake in postmenopausal women, the test for trend was borderline statistically significant (Ptrend = 0.05). There was no significant interaction between vitamin D and calcium intake and cancer risk (Pinteraction = 0.57 and 0.22 in pre- and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk. (Less)
Please use this url to cite or link to this publication:
@article{c685014e-ac90-4166-8b92-0065f71bea69,
  abstract     = {Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for pre- and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95% CI were 1.07 (0.871.32) and 1.02 (0.901.16) for pre- and postmenopausal women, respectively. The corresponding HR and 95% CIs for calcium intake were 0.98 (0.801.19) and 0.90 (0.791.02), respectively. For calcium intake in postmenopausal women, the test for trend was borderline statistically significant (Ptrend = 0.05). There was no significant interaction between vitamin D and calcium intake and cancer risk (Pinteraction = 0.57 and 0.22 in pre- and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk.},
  author       = {Abbas, Sascha and Linseisen, Jakob and Rohrmann, Sabine and Chang-Claude, Jenny and Peeters, Petra H. and Engel, Pierre and Brustad, Magritt and Lund, Eiliv and Skeie, Guri and Olsen, Anja and Tjonneland, Anne and Overvad, Kim and Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise and Fagherazzi, Guy and Kaaks, Rudolf and Boeing, Heiner and Buijsse, Brian and Adarakis, George and Ouranos, Vassilis and Trichopoulou, Antonia and Masala, Giovanna and Krogh, Vittorio and Mattiello, Amalia and Tumino, Rosario and Sacerdote, Carlotta and Buckland, Genevieve and Argueelles Suarez, Marcial Vicente and Sanchez, Maria-Jose and Chirlaque, Maria-Dolores and Barricarte, Aurelio and Amiano, Pilar and Manjer, Jonas and Wirfalt, Elisabet},
  issn         = {1532-7914},
  language     = {eng},
  number       = {2},
  pages        = {178--187},
  publisher    = {Lawrence Erlbaum Associates},
  series       = {Nutrition and Cancer},
  title        = {Dietary Intake of Vitamin D and Calcium and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1080/01635581.2013.752018},
  volume       = {65},
  year         = {2013},
}