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Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition.

Piel, Sarah LU orcid ; Ehinger, Johannes LU orcid ; Elmer, Eskil LU orcid and Hansson, Magnus LU orcid (2015) In Acta Physiologica 213(1). p.171-180
Abstract
Metformin is a widely used antidiabetic drug associated with the rare side effect of lactic acidosis which has been proposed to be linked to drug-induced mitochondrial dysfunction. Using respirometry, the aim of this study was to evaluate mitochondrial toxicity of metformin to human blood cells in relation to that of phenformin, a biguanide analogue withdrawn in most countries due to a high incidence of lactic acidosis.
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Physiologica
volume
213
issue
1
pages
171 - 180
publisher
Wiley-Blackwell
external identifiers
  • pmid:24801139
  • wos:000346475000012
  • scopus:84940845680
  • pmid:24801139
ISSN
1748-1716
DOI
10.1111/apha.12311
language
English
LU publication?
yes
id
c6f1f9fb-b61b-4cf3-b525-b6ab405663a7 (old id 4455749)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24801139?dopt=Abstract
date added to LUP
2016-04-01 10:21:44
date last changed
2025-10-14 09:32:08
@article{c6f1f9fb-b61b-4cf3-b525-b6ab405663a7,
  abstract     = {{Metformin is a widely used antidiabetic drug associated with the rare side effect of lactic acidosis which has been proposed to be linked to drug-induced mitochondrial dysfunction. Using respirometry, the aim of this study was to evaluate mitochondrial toxicity of metformin to human blood cells in relation to that of phenformin, a biguanide analogue withdrawn in most countries due to a high incidence of lactic acidosis.}},
  author       = {{Piel, Sarah and Ehinger, Johannes and Elmer, Eskil and Hansson, Magnus}},
  issn         = {{1748-1716}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{171--180}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Physiologica}},
  title        = {{Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition.}},
  url          = {{http://dx.doi.org/10.1111/apha.12311}},
  doi          = {{10.1111/apha.12311}},
  volume       = {{213}},
  year         = {{2015}},
}