Association between plasma glucose-dependent insulinotropic polypeptide and active adiponectin in normoglycemic women
Salvatierra, Isidora ; Parada, Javier ; Cataldo, Rodrigo LU
; Galgani, José Eduardo
; Alberti, Gigliola
; Labayen, Idoia
and Santos, José L.
(2026)
In Endocrine Connections
15(1).
- Abstract
Background/objectives: Glucose-dependent insulinotropic polypeptide (GIP) is secreted by enteroendocrine K cells in response to nutrient ingestion. The aims of this study were: i) to evaluate the cross-sectional associations between plasma GIP change in response to an oral glucose challenge (as a surrogate of GIP secretion) with obesity-related anthropometric measurements, fasting inflammatory biomarkers, and fasting circulating adipokines; and ii) to evaluate the feasibility of using postprandial plasma GIP as a biomarker of adiposity-related phenotypes in response to starch-based meals. Methods: Fifty normoglycemic women without obesity (19-32 years) were evaluated with an oral glucose tolerance test (OGTT). A feasibility study was... (More)
Background/objectives: Glucose-dependent insulinotropic polypeptide (GIP) is secreted by enteroendocrine K cells in response to nutrient ingestion. The aims of this study were: i) to evaluate the cross-sectional associations between plasma GIP change in response to an oral glucose challenge (as a surrogate of GIP secretion) with obesity-related anthropometric measurements, fasting inflammatory biomarkers, and fasting circulating adipokines; and ii) to evaluate the feasibility of using postprandial plasma GIP as a biomarker of adiposity-related phenotypes in response to starch-based meals. Methods: Fifty normoglycemic women without obesity (19-32 years) were evaluated with an oral glucose tolerance test (OGTT). A feasibility study was conducted in a subset of eight women to estimate responses to starch-based meals (25 g of starch). Postprandial glycemic-related changes in plasma hormones/metabolites were assessed, and circulating adipokines and inflammatory biomarkers in fasting conditions. Results: The incremental-GIP change after 2 h OGTT was significantly associated with waist circumference (rho=0.34; P=0.02), fasting plasma TNF-α (rho=0.54; P=0.0002), and white blood cell count (rho=0.39; P=0.008), but not with MCP-1, total adiponectin, leptin, or the free leptin index. A strong inverse association was found between incremental-GIP change and fasting plasma high-molecular-weight (HMW) adiponectin (rho=0.50; P=0.0004), which remained significant after adjusting for age and body mass index. Conclusion: An inverse association was found between postprandial GIP levels and circulating HMW-adiponectin levels in humans. This work highlights the suitability of using postprandial plasma GIP as a biomarker for metabolic disturbances of increased adiposity, even in the absence of obesity.
(Less)
- author
- Salvatierra, Isidora
; Parada, Javier
; Cataldo, Rodrigo
LU
; Galgani, José Eduardo
; Alberti, Gigliola
; Labayen, Idoia
and Santos, José L.
- organization
- publishing date
- 2026-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- adipokines, adiponectin, GIP, high molecular weight adiponectin, incretins
- in
- Endocrine Connections
- volume
- 15
- issue
- 1
- article number
- e250804
- publisher
- BioScientifica
- external identifiers
-
- pmid:41528263
- scopus:105028854828
- ISSN
- 2049-3614
- DOI
- 10.1530/EC-25-0804
- language
- English
- LU publication?
- yes
- id
- c8b3ef55-8e79-4dc2-8298-c49a98cfb3b7
- date added to LUP
- 2026-02-25 10:49:39
- date last changed
- 2026-04-22 22:14:33
@article{c8b3ef55-8e79-4dc2-8298-c49a98cfb3b7,
abstract = {{<p>Background/objectives: Glucose-dependent insulinotropic polypeptide (GIP) is secreted by enteroendocrine K cells in response to nutrient ingestion. The aims of this study were: i) to evaluate the cross-sectional associations between plasma GIP change in response to an oral glucose challenge (as a surrogate of GIP secretion) with obesity-related anthropometric measurements, fasting inflammatory biomarkers, and fasting circulating adipokines; and ii) to evaluate the feasibility of using postprandial plasma GIP as a biomarker of adiposity-related phenotypes in response to starch-based meals. Methods: Fifty normoglycemic women without obesity (19-32 years) were evaluated with an oral glucose tolerance test (OGTT). A feasibility study was conducted in a subset of eight women to estimate responses to starch-based meals (25 g of starch). Postprandial glycemic-related changes in plasma hormones/metabolites were assessed, and circulating adipokines and inflammatory biomarkers in fasting conditions. Results: The incremental-GIP change after 2 h OGTT was significantly associated with waist circumference (rho=0.34; P=0.02), fasting plasma TNF-α (rho=0.54; P=0.0002), and white blood cell count (rho=0.39; P=0.008), but not with MCP-1, total adiponectin, leptin, or the free leptin index. A strong inverse association was found between incremental-GIP change and fasting plasma high-molecular-weight (HMW) adiponectin (rho=0.50; P=0.0004), which remained significant after adjusting for age and body mass index. Conclusion: An inverse association was found between postprandial GIP levels and circulating HMW-adiponectin levels in humans. This work highlights the suitability of using postprandial plasma GIP as a biomarker for metabolic disturbances of increased adiposity, even in the absence of obesity.</p>}},
author = {{Salvatierra, Isidora and Parada, Javier and Cataldo, Rodrigo and Galgani, José Eduardo and Alberti, Gigliola and Labayen, Idoia and Santos, José L.}},
issn = {{2049-3614}},
keywords = {{adipokines; adiponectin; GIP; high molecular weight adiponectin; incretins}},
language = {{eng}},
number = {{1}},
publisher = {{BioScientifica}},
series = {{Endocrine Connections}},
title = {{Association between plasma glucose-dependent insulinotropic polypeptide and active adiponectin in normoglycemic women}},
url = {{http://dx.doi.org/10.1530/EC-25-0804}},
doi = {{10.1530/EC-25-0804}},
volume = {{15}},
year = {{2026}},
}