Antiplatelet therapy contributes to a higher risk of traumatic intracranial hemorrhage compared to anticoagulation therapy in ground-level falls : a single-center retrospective study
(2022) In European Journal of Trauma and Emergency Surgery 48(6). p.4909-4917- Abstract
Background: Traumatic brain injury (TBI) is a common injury and constitutes up to 3% of emergency department (ED) visits. Current studies show that TBI is most commonly inflicted in older patients after ground-level falls. These patients often take medications affecting coagulation such as anticoagulants or antiplatelet drugs. Guidelines for ED TBI-management assume that anticoagulation therapy (ACT) confers a higher risk of traumatic intracranial hemorrhage (TICH) than antiplatelet therapy (APT). However, recent studies have challenged this. This study aimed to evaluate if oral anticoagulation and platelet inhibitors affected rate of TICH in head-trauma patients with ground-level falls. Methods: This was a retrospective review of... (More)
Background: Traumatic brain injury (TBI) is a common injury and constitutes up to 3% of emergency department (ED) visits. Current studies show that TBI is most commonly inflicted in older patients after ground-level falls. These patients often take medications affecting coagulation such as anticoagulants or antiplatelet drugs. Guidelines for ED TBI-management assume that anticoagulation therapy (ACT) confers a higher risk of traumatic intracranial hemorrhage (TICH) than antiplatelet therapy (APT). However, recent studies have challenged this. This study aimed to evaluate if oral anticoagulation and platelet inhibitors affected rate of TICH in head-trauma patients with ground-level falls. Methods: This was a retrospective review of medical records during January 1, 2017 to December 31, 2017 and January 1 2020 to December 31, 2020 of all patients seeking ED care because of head-trauma. Patients ≥ 18 years with ground-level falls were included. Results: The study included 1938 head-trauma patients with ground-level falls. Median age of patients with TICH was 81 years. The RR for TICH in APT-patients compared to patients without medication affecting coagulation was 1.72 (p = 0.01) (95% Confidence Interval (CI) 1.13–2.60) and 1.08 (p = 0.73), (95% CI 0.70–1.67) in ACT-patients. APT was independently associated with TICH in regression analysis (OR 1.59 (95% CI 1.02–2.49), p = 0.041). Conclusion: This study adds to the growing evidence that APT-patients with ground-level falls might have as high or higher risk of TICH than ACT-patients. This is not addressed in the current guidelines which may need to be updated. We therefore recommend broad prospective studies.
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- author
- Vedin, Tomas LU ; Lundager Forberg, Jakob LU ; Anefjäll, Ebba ; Lehtinen, Riikka ; Faisal, Mohammed and Edelhamre, Marcus LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- (MESH), Anticoagulants, Brain injuries, Intracranial hemorrhages, Tomography, Traumatic, X-ray computed
- in
- European Journal of Trauma and Emergency Surgery
- volume
- 48
- issue
- 6
- pages
- 4909 - 4917
- publisher
- Urban & Vogel
- external identifiers
-
- scopus:85132341261
- pmid:35732809
- ISSN
- 1863-9933
- DOI
- 10.1007/s00068-022-02016-8
- language
- English
- LU publication?
- yes
- id
- c8cdf7ee-af4d-4da3-ad9a-bf1a0044577b
- date added to LUP
- 2022-09-21 14:59:56
- date last changed
- 2024-06-13 19:30:31
@article{c8cdf7ee-af4d-4da3-ad9a-bf1a0044577b,
abstract = {{<p>Background: Traumatic brain injury (TBI) is a common injury and constitutes up to 3% of emergency department (ED) visits. Current studies show that TBI is most commonly inflicted in older patients after ground-level falls. These patients often take medications affecting coagulation such as anticoagulants or antiplatelet drugs. Guidelines for ED TBI-management assume that anticoagulation therapy (ACT) confers a higher risk of traumatic intracranial hemorrhage (TICH) than antiplatelet therapy (APT). However, recent studies have challenged this. This study aimed to evaluate if oral anticoagulation and platelet inhibitors affected rate of TICH in head-trauma patients with ground-level falls. Methods: This was a retrospective review of medical records during January 1, 2017 to December 31, 2017 and January 1 2020 to December 31, 2020 of all patients seeking ED care because of head-trauma. Patients ≥ 18 years with ground-level falls were included. Results: The study included 1938 head-trauma patients with ground-level falls. Median age of patients with TICH was 81 years. The RR for TICH in APT-patients compared to patients without medication affecting coagulation was 1.72 (p = 0.01) (95% Confidence Interval (CI) 1.13–2.60) and 1.08 (p = 0.73), (95% CI 0.70–1.67) in ACT-patients. APT was independently associated with TICH in regression analysis (OR 1.59 (95% CI 1.02–2.49), p = 0.041). Conclusion: This study adds to the growing evidence that APT-patients with ground-level falls might have as high or higher risk of TICH than ACT-patients. This is not addressed in the current guidelines which may need to be updated. We therefore recommend broad prospective studies.</p>}},
author = {{Vedin, Tomas and Lundager Forberg, Jakob and Anefjäll, Ebba and Lehtinen, Riikka and Faisal, Mohammed and Edelhamre, Marcus}},
issn = {{1863-9933}},
keywords = {{(MESH); Anticoagulants; Brain injuries; Intracranial hemorrhages; Tomography; Traumatic; X-ray computed}},
language = {{eng}},
number = {{6}},
pages = {{4909--4917}},
publisher = {{Urban & Vogel}},
series = {{European Journal of Trauma and Emergency Surgery}},
title = {{Antiplatelet therapy contributes to a higher risk of traumatic intracranial hemorrhage compared to anticoagulation therapy in ground-level falls : a single-center retrospective study}},
url = {{http://dx.doi.org/10.1007/s00068-022-02016-8}},
doi = {{10.1007/s00068-022-02016-8}},
volume = {{48}},
year = {{2022}},
}