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Complement C3 and incident hospitalization due to chronic kidney disease : a population-based cohort study

Bao, Xue LU ; Borné, Yan LU ; Muhammad, Iram Faqir LU ; Schulz, Christina Alexandra LU ; Persson, Margaretha LU ; Orho-Melander, Marju LU ; Niu, Kaijun; Christensson, Anders LU and Engström, Gunnar LU (2019) In BMC Nephrology 20.
Abstract

BACKGROUND: Circulating C3 has been associated with diabetes and hypertension, which are the leading causes of chronic kidney disease (CKD). C3 activation is considered to contribute to several renal diseases. Here we examined whether elevated C3 concentration is associated with hospitalization due to CKD in the general population, and whether this relationship is mediated by factors such as diabetes and hypertension. METHODS: Baseline plasma C3 was quantified in 4552 participants, without previous hospital admission due to CKD, from the Malmö Diet and Cancer cohort study. Incidence of first hospitalization due to CKD (main diagnosis) was investigated in relation to C3 levels using Cox proportional hazards regression models after a mean... (More)

BACKGROUND: Circulating C3 has been associated with diabetes and hypertension, which are the leading causes of chronic kidney disease (CKD). C3 activation is considered to contribute to several renal diseases. Here we examined whether elevated C3 concentration is associated with hospitalization due to CKD in the general population, and whether this relationship is mediated by factors such as diabetes and hypertension. METHODS: Baseline plasma C3 was quantified in 4552 participants, without previous hospital admission due to CKD, from the Malmö Diet and Cancer cohort study. Incidence of first hospitalization due to CKD (main diagnosis) was investigated in relation to C3 levels using Cox proportional hazards regression models after a mean follow-up of 19.2 ± 4.16 years. Traditional risk factors of CKD including diabetes, blood pressure, C-reactive protein and baseline renal function were considered in adjustments and sensitivity analyses. RESULTS: During the follow-up period, 94 subjects were admitted to hospital due to CKD. After multivariate adjustment, the hazard ratios (95% confidence interval) for hospitalization from CKD across quartiles of C3 were 1.00 (reference), 1.68 (0.69, 4.13), 2.71 (1.15, 6.39), and 3.16 (1.36, 7.34) (p for trend = 0.003). Results were generally consistent across different sensitivity analyses. CONCLUSIONS: These findings indicate that C3 is associated with incidence of first hospitalization due to CKD in the general population. The observed relationship cannot be entirely attributed to hyperglycemia and hypertension.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chronic kidney disease, Complement C3, Diabetes, Hypertension
in
BMC Nephrology
volume
20
publisher
BioMed Central
external identifiers
  • scopus:85061963513
ISSN
1471-2369
DOI
10.1186/s12882-019-1248-7
language
English
LU publication?
yes
id
c8de1ae3-53d3-4933-bf43-3900bac5298f
date added to LUP
2019-03-06 11:06:48
date last changed
2019-03-27 04:40:00
@article{c8de1ae3-53d3-4933-bf43-3900bac5298f,
  abstract     = {<p>BACKGROUND: Circulating C3 has been associated with diabetes and hypertension, which are the leading causes of chronic kidney disease (CKD). C3 activation is considered to contribute to several renal diseases. Here we examined whether elevated C3 concentration is associated with hospitalization due to CKD in the general population, and whether this relationship is mediated by factors such as diabetes and hypertension. METHODS: Baseline plasma C3 was quantified in 4552 participants, without previous hospital admission due to CKD, from the Malmö Diet and Cancer cohort study. Incidence of first hospitalization due to CKD (main diagnosis) was investigated in relation to C3 levels using Cox proportional hazards regression models after a mean follow-up of 19.2 ± 4.16 years. Traditional risk factors of CKD including diabetes, blood pressure, C-reactive protein and baseline renal function were considered in adjustments and sensitivity analyses. RESULTS: During the follow-up period, 94 subjects were admitted to hospital due to CKD. After multivariate adjustment, the hazard ratios (95% confidence interval) for hospitalization from CKD across quartiles of C3 were 1.00 (reference), 1.68 (0.69, 4.13), 2.71 (1.15, 6.39), and 3.16 (1.36, 7.34) (p for trend = 0.003). Results were generally consistent across different sensitivity analyses. CONCLUSIONS: These findings indicate that C3 is associated with incidence of first hospitalization due to CKD in the general population. The observed relationship cannot be entirely attributed to hyperglycemia and hypertension.</p>},
  articleno    = {61},
  author       = {Bao, Xue and Borné, Yan and Muhammad, Iram Faqir and Schulz, Christina Alexandra and Persson, Margaretha and Orho-Melander, Marju and Niu, Kaijun and Christensson, Anders and Engström, Gunnar},
  issn         = {1471-2369},
  keyword      = {Chronic kidney disease,Complement C3,Diabetes,Hypertension},
  language     = {eng},
  month        = {02},
  publisher    = {BioMed Central},
  series       = {BMC Nephrology},
  title        = {Complement C3 and incident hospitalization due to chronic kidney disease : a population-based cohort study},
  url          = {http://dx.doi.org/10.1186/s12882-019-1248-7},
  volume       = {20},
  year         = {2019},
}