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Gender-related differences in urothelial carcinoma of the bladder : a population-based study from the Swedish National Registry of Urinary Bladder Cancer

Thorstenson, Andreas; Hagberg, Oskar LU ; Ljungberg, Börje; Liedberg, Fredrik LU ; Jancke, Georg; Holmäng, Sten; Malmström, Per-Uno LU ; Hosseini, Abolfazl and Jahnson, Staffan (2016) In Scandinavian Journal of Urology2013-01-01+01:00 50(4). p.292-297
Abstract

OBJECTIVE: The aim of this investigation was to describe tumour characteristics, treatments and survival in patients with urinary bladder cancer (UBC) in a national population-based cohort, with special reference to gender-related differences.

MATERIAL AND METHODS: All primary UBC patients with urothelial pathology reported to the Swedish National Registry of Urinary Bladder Cancer (SNRUBC) from 1997 to 2011 were included in the study. Groups were compared regarding tumour, node, metastasis classification, primary treatment and survival.

RESULTS: In total, 30,310 patients (74.9% male, 25.1% female) with UBC were analysed. A larger proportion of women than men had stage T2-T4 (p < 0.001), and women also had more G1 tumours... (More)

OBJECTIVE: The aim of this investigation was to describe tumour characteristics, treatments and survival in patients with urinary bladder cancer (UBC) in a national population-based cohort, with special reference to gender-related differences.

MATERIAL AND METHODS: All primary UBC patients with urothelial pathology reported to the Swedish National Registry of Urinary Bladder Cancer (SNRUBC) from 1997 to 2011 were included in the study. Groups were compared regarding tumour, node, metastasis classification, primary treatment and survival.

RESULTS: In total, 30,310 patients (74.9% male, 25.1% female) with UBC were analysed. A larger proportion of women than men had stage T2-T4 (p < 0.001), and women also had more G1 tumours (p < 0.001). However, compared to women, a larger proportion of men with carcinoma in situ or T1G3 received intravesical treatment with bacillus Calmette-Guérin or intravesical chemotherapy, and a larger proportion of men with stage T2-T4 underwent radical cystectomy (38% men vs 33% women, p < 0.0001). The cancer-specific survival at 5 years was 77% for men and 72% for women (p < 0.001), and the relative survival at 5 years was 72% for men and 69% for women (p < 0.001).

CONCLUSIONS: In this population-based cohort comprising virtually all patients diagnosed with UBC in Sweden between 1997 and 2011, female gender was associated with inferior cancer-specific and relative survival. Although women had a higher rate of aggressive tumours, a smaller proportion of women than men received optimal treatment.

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organization
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type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Urology2013-01-01+01:00
volume
50
issue
4
pages
6 pages
publisher
Taylor & Francis
external identifiers
  • Scopus:84961391574
  • WOS:000379024000009
ISSN
2168-1813
DOI
10.3109/21681805.2016.1158207
language
English
LU publication?
yes
id
c8e7fe56-1dbf-42a7-8b1b-8dfdcbc9c2a2
date added to LUP
2016-04-12 15:07:50
date last changed
2017-02-12 04:31:59
@article{c8e7fe56-1dbf-42a7-8b1b-8dfdcbc9c2a2,
  abstract     = {<p>OBJECTIVE: The aim of this investigation was to describe tumour characteristics, treatments and survival in patients with urinary bladder cancer (UBC) in a national population-based cohort, with special reference to gender-related differences.</p><p>MATERIAL AND METHODS: All primary UBC patients with urothelial pathology reported to the Swedish National Registry of Urinary Bladder Cancer (SNRUBC) from 1997 to 2011 were included in the study. Groups were compared regarding tumour, node, metastasis classification, primary treatment and survival.</p><p>RESULTS: In total, 30,310 patients (74.9% male, 25.1% female) with UBC were analysed. A larger proportion of women than men had stage T2-T4 (p &lt; 0.001), and women also had more G1 tumours (p &lt; 0.001). However, compared to women, a larger proportion of men with carcinoma in situ or T1G3 received intravesical treatment with bacillus Calmette-Guérin or intravesical chemotherapy, and a larger proportion of men with stage T2-T4 underwent radical cystectomy (38% men vs 33% women, p &lt; 0.0001). The cancer-specific survival at 5 years was 77% for men and 72% for women (p &lt; 0.001), and the relative survival at 5 years was 72% for men and 69% for women (p &lt; 0.001).</p><p>CONCLUSIONS: In this population-based cohort comprising virtually all patients diagnosed with UBC in Sweden between 1997 and 2011, female gender was associated with inferior cancer-specific and relative survival. Although women had a higher rate of aggressive tumours, a smaller proportion of women than men received optimal treatment.</p>},
  author       = {Thorstenson, Andreas and Hagberg, Oskar and Ljungberg, Börje and Liedberg, Fredrik and Jancke, Georg and Holmäng, Sten and Malmström, Per-Uno and Hosseini, Abolfazl and Jahnson, Staffan},
  issn         = {2168-1813},
  language     = {eng},
  number       = {4},
  pages        = {292--297},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Urology2013-01-01+01:00},
  title        = {Gender-related differences in urothelial carcinoma of the bladder : a population-based study from the Swedish National Registry of Urinary Bladder Cancer},
  url          = {http://dx.doi.org/10.3109/21681805.2016.1158207},
  volume       = {50},
  year         = {2016},
}