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Ventilation management and outcomes in out-of-hospital cardiac arrest : a protocol for a preplanned secondary analysis of the TTM2 trial

Robba, Chiara ; Nielsen, Niklas LU ; Dankiewicz, Josef LU orcid ; Badenes, Rafael ; Battaglini, Denise ; Ball, Lorenzo ; Brunetti, Iole ; Pedro David, Wendel Garcia ; Young, Paul and Eastwood, Glenn , et al. (2022) In BMJ Open 12(3). p.058001-058001
Abstract

INTRODUCTION: Mechanical ventilation is a fundamental component in the management of patients post cardiac arrest. However, the ventilator settings and the gas-exchange targets used after cardiac arrest may not be optimal to minimise post-anoxic secondary brain injury. Therefore, questions remain regarding the best ventilator management in such patients. METHODS AND ANALYSIS: This is a preplanned analysis of the international randomised controlled trial, targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (OHCA)-target temperature management 2 (TTM2). The primary objective is to describe ventilatory settings and gas exchange in patients who required invasive mechanical ventilation and included in the... (More)

INTRODUCTION: Mechanical ventilation is a fundamental component in the management of patients post cardiac arrest. However, the ventilator settings and the gas-exchange targets used after cardiac arrest may not be optimal to minimise post-anoxic secondary brain injury. Therefore, questions remain regarding the best ventilator management in such patients. METHODS AND ANALYSIS: This is a preplanned analysis of the international randomised controlled trial, targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (OHCA)-target temperature management 2 (TTM2). The primary objective is to describe ventilatory settings and gas exchange in patients who required invasive mechanical ventilation and included in the TTM2 trial. Secondary objectives include evaluating the association of ventilator settings and gas-exchange values with 6 months mortality and neurological outcome. Adult patients after an OHCA who were included in the TTM2 trial and who received invasive mechanical ventilation will be eligible for this analysis. Data collected in the TTM2 trial that will be analysed include patients' prehospital characteristics, clinical examination, ventilator settings and arterial blood gases recorded at hospital and intensive care unit (ICU) admission and daily during ICU stay. ETHICS AND DISSEMINATION: The TTM2 study has been approved by the regional ethics committee at Lund University and by all relevant ethics boards in participating countries. No further ethical committee approval is required for this secondary analysis. Data will be disseminated to the scientific community by abstracts and by original articles submitted to peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT02908308.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adult intensive & critical care, clinical trials, respiratory physiology
in
BMJ Open
volume
12
issue
3
pages
058001 - 058001
publisher
BMJ Publishing Group
external identifiers
  • pmid:35241476
  • scopus:85125692248
ISSN
2044-6055
DOI
10.1136/bmjopen-2021-058001
language
English
LU publication?
yes
id
c8f2214b-5bbd-4aec-9f6f-746ad7c3fbc5
date added to LUP
2022-04-26 11:07:21
date last changed
2024-06-13 12:07:27
@article{c8f2214b-5bbd-4aec-9f6f-746ad7c3fbc5,
  abstract     = {{<p>INTRODUCTION: Mechanical ventilation is a fundamental component in the management of patients post cardiac arrest. However, the ventilator settings and the gas-exchange targets used after cardiac arrest may not be optimal to minimise post-anoxic secondary brain injury. Therefore, questions remain regarding the best ventilator management in such patients. METHODS AND ANALYSIS: This is a preplanned analysis of the international randomised controlled trial, targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (OHCA)-target temperature management 2 (TTM2). The primary objective is to describe ventilatory settings and gas exchange in patients who required invasive mechanical ventilation and included in the TTM2 trial. Secondary objectives include evaluating the association of ventilator settings and gas-exchange values with 6 months mortality and neurological outcome. Adult patients after an OHCA who were included in the TTM2 trial and who received invasive mechanical ventilation will be eligible for this analysis. Data collected in the TTM2 trial that will be analysed include patients' prehospital characteristics, clinical examination, ventilator settings and arterial blood gases recorded at hospital and intensive care unit (ICU) admission and daily during ICU stay. ETHICS AND DISSEMINATION: The TTM2 study has been approved by the regional ethics committee at Lund University and by all relevant ethics boards in participating countries. No further ethical committee approval is required for this secondary analysis. Data will be disseminated to the scientific community by abstracts and by original articles submitted to peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT02908308.</p>}},
  author       = {{Robba, Chiara and Nielsen, Niklas and Dankiewicz, Josef and Badenes, Rafael and Battaglini, Denise and Ball, Lorenzo and Brunetti, Iole and Pedro David, Wendel Garcia and Young, Paul and Eastwood, Glenn and Chew, Michelle S. and Jakobsen, Janus and Unden, Johan and Thomas, Matthew and Joannidis, Michael and Nichol, Alistair and Lundin, Andreas and Hollenberg, Jacob and Lilja, Gisela and Hammond, Naomi E. and Saxena, Manoj and Martin, Annborn and Solar, Miroslav and Taccone, Fabio Silvio and Friberg, Hans A. and Pelosi, Paolo}},
  issn         = {{2044-6055}},
  keywords     = {{adult intensive & critical care; clinical trials; respiratory physiology}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{3}},
  pages        = {{058001--058001}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{BMJ Open}},
  title        = {{Ventilation management and outcomes in out-of-hospital cardiac arrest : a protocol for a preplanned secondary analysis of the TTM2 trial}},
  url          = {{http://dx.doi.org/10.1136/bmjopen-2021-058001}},
  doi          = {{10.1136/bmjopen-2021-058001}},
  volume       = {{12}},
  year         = {{2022}},
}