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Clinical efficacy of a topical lactic acid bacterial microbiome in chronic rhinosinusitis: A randomized controlled trial

Mårtensson, Anders LU ; Abolhalaj, Milad LU ; Lindstedt, Malin LU ; Mårtensson, Anette LU ; Olofsson, Tobias LU ; Vasquez, Alejandra LU ; Greiff, Lennart LU and Cervin, Anders LU (2017) In Laryngoscope Investigative Otolaryngology 2(6). p.410-416
Abstract
Objective
A locally disturbed commensal microbiome might be an etiological factor in chronic rhinosinusitis (CRS) in general and in CRS without nasal polyps (CRSsNP) in particular. Lactic acid bacteria (LAB) have been suggested to restore commensal microbiomes. A honeybee LAB microbiome consisting of various lactobacilli and bifidobacteria have been found potent against CRS pathogens in vitro. Recently, we examined effects of single nasal administrations of this microbiome in healthy subjects and found it inert. In this study, we examined effects of repeated such administrations in patients with CRSsNP.

Study Design
The study was of a randomized, double-blinded, crossover, and sham-controlled... (More)
Objective
A locally disturbed commensal microbiome might be an etiological factor in chronic rhinosinusitis (CRS) in general and in CRS without nasal polyps (CRSsNP) in particular. Lactic acid bacteria (LAB) have been suggested to restore commensal microbiomes. A honeybee LAB microbiome consisting of various lactobacilli and bifidobacteria have been found potent against CRS pathogens in vitro. Recently, we examined effects of single nasal administrations of this microbiome in healthy subjects and found it inert. In this study, we examined effects of repeated such administrations in patients with CRSsNP.

Study Design
The study was of a randomized, double-blinded, crossover, and sham-controlled design.

Methods
Twenty patients received 2 weeks' treatment administered using a nasal spray-device. The subjects were monitored with regard to symptoms (SNOT-22 questionnaire, i.e., the primary efficacy variable), changes to their microbiome, and inflammatory products (IL-6, IL-8, TNF-, IL-8,a, and MPO) in nasal lavage fluids.

Results
Neither symptom scores, microbiological explorations, nor levels of inflammatory products in nasal lavage fluids were affected by LAB (c.f. sham).

Conclusion
Two weeks' nasal administration of a honeybee LAB microbiome to patients with CRSsNP is well tolerated but affects neither symptom severity nor the microbiological flora/local inflammatory activity.

Level of Evidence
1b (Less)
Abstract (Swedish)
Abstract
Objective
A locally disturbed commensal microbiome might be an etiological factor in chronic rhinosinusitis (CRS) in general and in CRS without nasal polyps (CRSsNP) in particular. Lactic acid bacteria (LAB) have been suggested to restore commensal microbiomes. A honeybee LAB microbiome consisting of various lactobacilli and bifidobacteria have been found potent against CRS pathogens in vitro. Recently, we examined effects of single nasal administrations of this microbiome in healthy subjects and found it inert. In this study, we examined effects of repeated such administrations in patients with CRSsNP.

Study Design
The study was of a randomized, double-blinded, crossover, and sham-controlled... (More)
Abstract
Objective
A locally disturbed commensal microbiome might be an etiological factor in chronic rhinosinusitis (CRS) in general and in CRS without nasal polyps (CRSsNP) in particular. Lactic acid bacteria (LAB) have been suggested to restore commensal microbiomes. A honeybee LAB microbiome consisting of various lactobacilli and bifidobacteria have been found potent against CRS pathogens in vitro. Recently, we examined effects of single nasal administrations of this microbiome in healthy subjects and found it inert. In this study, we examined effects of repeated such administrations in patients with CRSsNP.

Study Design
The study was of a randomized, double-blinded, crossover, and sham-controlled design.

Methods
Twenty patients received 2 weeks' treatment administered using a nasal spray-device. The subjects were monitored with regard to symptoms (SNOT-22 questionnaire, i.e., the primary efficacy variable), changes to their microbiome, and inflammatory products (IL-6, IL-8, TNF-, IL-8,a, and MPO) in nasal lavage fluids.

Results
Neither symptom scores, microbiological explorations, nor levels of inflammatory products in nasal lavage fluids were affected by LAB (c.f. sham).

Conclusion
Two weeks' nasal administration of a honeybee LAB microbiome to patients with CRSsNP is well tolerated but affects neither symptom severity nor the microbiological flora/local inflammatory activity.

Level of Evidence
1b (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Laryngoscope Investigative Otolaryngology
volume
2
issue
6
pages
410 - 416
publisher
Wiley
external identifiers
  • scopus:85055707125
ISSN
2378-8038
DOI
10.1002/lio2.93
language
English
LU publication?
yes
id
c90f3fe3-a413-47b7-887c-1cc794f3a689
date added to LUP
2023-08-04 22:44:40
date last changed
2023-08-28 09:28:44
@article{c90f3fe3-a413-47b7-887c-1cc794f3a689,
  abstract     = {{Objective<br/>A locally disturbed commensal microbiome might be an etiological factor in chronic rhinosinusitis (CRS) in general and in CRS without nasal polyps (CRSsNP) in particular. Lactic acid bacteria (LAB) have been suggested to restore commensal microbiomes. A honeybee LAB microbiome consisting of various lactobacilli and bifidobacteria have been found potent against CRS pathogens in vitro. Recently, we examined effects of single nasal administrations of this microbiome in healthy subjects and found it inert. In this study, we examined effects of repeated such administrations in patients with CRSsNP.<br/><br/>Study Design<br/>The study was of a randomized, double-blinded, crossover, and sham-controlled design.<br/><br/>Methods<br/>Twenty patients received 2 weeks' treatment administered using a nasal spray-device. The subjects were monitored with regard to symptoms (SNOT-22 questionnaire, i.e., the primary efficacy variable), changes to their microbiome, and inflammatory products (IL-6, IL-8, TNF-, IL-8,a, and MPO) in nasal lavage fluids.<br/><br/>Results<br/>Neither symptom scores, microbiological explorations, nor levels of inflammatory products in nasal lavage fluids were affected by LAB (c.f. sham).<br/><br/>Conclusion<br/>Two weeks' nasal administration of a honeybee LAB microbiome to patients with CRSsNP is well tolerated but affects neither symptom severity nor the microbiological flora/local inflammatory activity.<br/><br/>Level of Evidence<br/>1b}},
  author       = {{Mårtensson, Anders and Abolhalaj, Milad and Lindstedt, Malin and Mårtensson, Anette and Olofsson, Tobias and Vasquez, Alejandra and Greiff, Lennart and Cervin, Anders}},
  issn         = {{2378-8038}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{6}},
  pages        = {{410--416}},
  publisher    = {{Wiley}},
  series       = {{Laryngoscope Investigative Otolaryngology}},
  title        = {{Clinical efficacy of a topical lactic acid bacterial microbiome in chronic rhinosinusitis: A randomized controlled trial}},
  url          = {{http://dx.doi.org/10.1002/lio2.93}},
  doi          = {{10.1002/lio2.93}},
  volume       = {{2}},
  year         = {{2017}},
}