Immunohistochemical profiles in primary lung cancers and epithelial pulmonary metastases
(2019) In Human Pathology 84. p.221-230- Abstract
Correct diagnosis of pulmonary tumors is essential for treatment decision and often relies on immunohistochemical markers. We stained tissue microarrays from resected primary lung cancer (n = 665) and pulmonary metastases (n = 425) for CK7, CK20, CDX2, CK5, p40, p63, TTF-1, napsin A, GATA3, and PAX8 to systematically assess the diagnostic value of these markers. Primary lung adenocarcinomas expressed TTF-1 in 90% and napsin A in 84% of the cases, whereas 10% were positive for p63, 7% for CDX2, 2% for CK20, and 2% for GATA3. Only 68% of the lung adenocarcinomas were positive for CK7, TTF-1, and napsin A and negative for all other markers. Primary lung squamous cell carcinomas expressed CK5, p40, and p63 in 94%-97% of cases, whereas 44%... (More)
Correct diagnosis of pulmonary tumors is essential for treatment decision and often relies on immunohistochemical markers. We stained tissue microarrays from resected primary lung cancer (n = 665) and pulmonary metastases (n = 425) for CK7, CK20, CDX2, CK5, p40, p63, TTF-1, napsin A, GATA3, and PAX8 to systematically assess the diagnostic value of these markers. Primary lung adenocarcinomas expressed TTF-1 in 90% and napsin A in 84% of the cases, whereas 10% were positive for p63, 7% for CDX2, 2% for CK20, and 2% for GATA3. Only 68% of the lung adenocarcinomas were positive for CK7, TTF-1, and napsin A and negative for all other markers. Primary lung squamous cell carcinomas expressed CK5, p40, and p63 in 94%-97% of cases, whereas 44% were positive for CK7, 20% for GATA3, 7% for CDX2, and 3% for TTF-1. Rare cases expressed PAX8, CK20, or napsin A. Pulmonary metastases of colorectal cancer were positive for CK20 in 83% and CDX2 in 99% of the cases. Rare cases expressed CK7, p63, or PAX8, whereas 4% expressed TTF-1. Pulmonary metastases of renal cell carcinomas were positive for PAX8 in 74%, napsin A in 7%, and CK7 in 7% of the cases. Pulmonary metastases of breast cancer were positive for GATA3 in 93% and CK7 in 78% of the cases, whereas 15% expressed CK5. Information on expression and patterns of immunohistochemical markers facilitates histopathological diagnostics. Evidently, unusual immune profiles occur and may lead to incorrect diagnosis.
(Less)
- author
- Vidarsdottir, Halla LU ; Tran, Lena ; Nodin, Björn LU ; Jirström, Karin LU ; Planck, Maria LU ; Jönsson, Per LU ; Mattsson, Johanna S.M. ; Botling, Johan ; Micke, Patrick and Brunnström, Hans LU
- organization
-
- Improved diagnostics and prognostics of lung cancer and metastases to the lungs (research group)
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- Personalized Pathology & Cancer Therapy (research group)
- Research Group Lung Cancer (research group)
- Thoracic Surgery
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- CDX2, Cytokeratin, GATA3, Napsin A, Tissue microarray, TTF-1
- in
- Human Pathology
- volume
- 84
- pages
- 10 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:30389437
- scopus:85060112849
- ISSN
- 0046-8177
- DOI
- 10.1016/j.humpath.2018.10.009
- project
- Histopathological and molecular diagnostics of lung cancer
- language
- English
- LU publication?
- yes
- id
- c95e777f-4e87-48e6-ac8a-4b6d8a7922ca
- date added to LUP
- 2019-01-28 12:50:01
- date last changed
- 2024-09-03 11:15:47
@article{c95e777f-4e87-48e6-ac8a-4b6d8a7922ca, abstract = {{<p>Correct diagnosis of pulmonary tumors is essential for treatment decision and often relies on immunohistochemical markers. We stained tissue microarrays from resected primary lung cancer (n = 665) and pulmonary metastases (n = 425) for CK7, CK20, CDX2, CK5, p40, p63, TTF-1, napsin A, GATA3, and PAX8 to systematically assess the diagnostic value of these markers. Primary lung adenocarcinomas expressed TTF-1 in 90% and napsin A in 84% of the cases, whereas 10% were positive for p63, 7% for CDX2, 2% for CK20, and 2% for GATA3. Only 68% of the lung adenocarcinomas were positive for CK7, TTF-1, and napsin A and negative for all other markers. Primary lung squamous cell carcinomas expressed CK5, p40, and p63 in 94%-97% of cases, whereas 44% were positive for CK7, 20% for GATA3, 7% for CDX2, and 3% for TTF-1. Rare cases expressed PAX8, CK20, or napsin A. Pulmonary metastases of colorectal cancer were positive for CK20 in 83% and CDX2 in 99% of the cases. Rare cases expressed CK7, p63, or PAX8, whereas 4% expressed TTF-1. Pulmonary metastases of renal cell carcinomas were positive for PAX8 in 74%, napsin A in 7%, and CK7 in 7% of the cases. Pulmonary metastases of breast cancer were positive for GATA3 in 93% and CK7 in 78% of the cases, whereas 15% expressed CK5. Information on expression and patterns of immunohistochemical markers facilitates histopathological diagnostics. Evidently, unusual immune profiles occur and may lead to incorrect diagnosis.</p>}}, author = {{Vidarsdottir, Halla and Tran, Lena and Nodin, Björn and Jirström, Karin and Planck, Maria and Jönsson, Per and Mattsson, Johanna S.M. and Botling, Johan and Micke, Patrick and Brunnström, Hans}}, issn = {{0046-8177}}, keywords = {{CDX2; Cytokeratin; GATA3; Napsin A; Tissue microarray; TTF-1}}, language = {{eng}}, pages = {{221--230}}, publisher = {{Elsevier}}, series = {{Human Pathology}}, title = {{Immunohistochemical profiles in primary lung cancers and epithelial pulmonary metastases}}, url = {{http://dx.doi.org/10.1016/j.humpath.2018.10.009}}, doi = {{10.1016/j.humpath.2018.10.009}}, volume = {{84}}, year = {{2019}}, }