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T-cell and B-cell perturbations are similar in ART-naive HIV-1 and HIV-1/2 dually infected patients

Hønge, Bo L. ; Petersen, Mikkel S. ; Jespersen, Sanne ; Medina, Candida ; Té, David D.S. ; Kjerulff, Bertram ; Jensen, Mads M. ; Steiniche, Ditte ; Esbjörnsson, Joakim LU orcid and Laursen, Alex L. , et al. (2019) In AIDS 33(7). p.1143-1153
Abstract

BACKGROUND: HIV-2 may slow progression of a subsequently acquired HIV-1 infection through cross-neutralizing antibodies and polyfunctional CD8 T cells. We hypothesized that HIV-1/2 dually infected patients compared with HIV-1-infected patients had more preserved immune maturation subsets and less immune activation of T and B cells. METHODS: ART-naive patients with HIV-1 (n = 83) or HIV-1/2 dual (n = 27) infections were included in this cross-sectional study at an HIV clinic in Guinea-Bissau. Peripheral blood mononuclear cells (PBMCs) were analyzed by flow cytometry according to T-cell maturation and activation, regulatory T-cell fraction, and B-cell maturation and activation. RESULTS: HIV-1/2 dually infected patients had lower levels of... (More)

BACKGROUND: HIV-2 may slow progression of a subsequently acquired HIV-1 infection through cross-neutralizing antibodies and polyfunctional CD8 T cells. We hypothesized that HIV-1/2 dually infected patients compared with HIV-1-infected patients had more preserved immune maturation subsets and less immune activation of T and B cells. METHODS: ART-naive patients with HIV-1 (n = 83) or HIV-1/2 dual (n = 27) infections were included in this cross-sectional study at an HIV clinic in Guinea-Bissau. Peripheral blood mononuclear cells (PBMCs) were analyzed by flow cytometry according to T-cell maturation and activation, regulatory T-cell fraction, and B-cell maturation and activation. RESULTS: HIV-1/2 dually infected patients had lower levels of HIV-1 RNA compared with patients with HIV-1 infection, but the levels of total HIV RNA (HIV-1 and HIV-2) were similar in the two patient groups. T-cell maturation, and proportions of regulatory T cells (FoxP3+) were also similar in the two groups. HIV-1/2 dually infected patients had higher proportions of CD4 and CD8 T cells positive for the activation marker CD38, but there was no difference in other T-cell activation markers (CD28, CTLA-4, PD-1). HIV-1/2 dually infected patients also had higher proportions of IgM-only B cells and plasmablasts. CONCLUSION: HIV-1/2 was not associated with less immune perturbations than for HIV-1 infection.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
AIDS
volume
33
issue
7
pages
11 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85065514336
  • pmid:30845069
ISSN
0269-9370
DOI
10.1097/QAD.0000000000002185
language
English
LU publication?
yes
id
c9d4b383-e1d7-4403-afd6-05ec7e9fa586
date added to LUP
2019-05-22 10:59:48
date last changed
2024-04-30 09:22:34
@article{c9d4b383-e1d7-4403-afd6-05ec7e9fa586,
  abstract     = {{<p>BACKGROUND: HIV-2 may slow progression of a subsequently acquired HIV-1 infection through cross-neutralizing antibodies and polyfunctional CD8 T cells. We hypothesized that HIV-1/2 dually infected patients compared with HIV-1-infected patients had more preserved immune maturation subsets and less immune activation of T and B cells. METHODS: ART-naive patients with HIV-1 (n = 83) or HIV-1/2 dual (n = 27) infections were included in this cross-sectional study at an HIV clinic in Guinea-Bissau. Peripheral blood mononuclear cells (PBMCs) were analyzed by flow cytometry according to T-cell maturation and activation, regulatory T-cell fraction, and B-cell maturation and activation. RESULTS: HIV-1/2 dually infected patients had lower levels of HIV-1 RNA compared with patients with HIV-1 infection, but the levels of total HIV RNA (HIV-1 and HIV-2) were similar in the two patient groups. T-cell maturation, and proportions of regulatory T cells (FoxP3+) were also similar in the two groups. HIV-1/2 dually infected patients had higher proportions of CD4 and CD8 T cells positive for the activation marker CD38, but there was no difference in other T-cell activation markers (CD28, CTLA-4, PD-1). HIV-1/2 dually infected patients also had higher proportions of IgM-only B cells and plasmablasts. CONCLUSION: HIV-1/2 was not associated with less immune perturbations than for HIV-1 infection.</p>}},
  author       = {{Hønge, Bo L. and Petersen, Mikkel S. and Jespersen, Sanne and Medina, Candida and Té, David D.S. and Kjerulff, Bertram and Jensen, Mads M. and Steiniche, Ditte and Esbjörnsson, Joakim and Laursen, Alex L. and Wejse, Christian and Krarup, Henrik and Møller, Bjarne K. and Erikstrup, Christian}},
  issn         = {{0269-9370}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1143--1153}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{AIDS}},
  title        = {{T-cell and B-cell perturbations are similar in ART-naive HIV-1 and HIV-1/2 dually infected patients}},
  url          = {{http://dx.doi.org/10.1097/QAD.0000000000002185}},
  doi          = {{10.1097/QAD.0000000000002185}},
  volume       = {{33}},
  year         = {{2019}},
}