True infection or contamination in patients with positive Cutibacterium blood cultures-a retrospective cohort study
Boman, Jolin ; Nilson, Bo LU
; Sunnerhagen, Torgny
LU
and Rasmussen, Magnus
LU
(2022)
In European Journal of Clinical Microbiology and Infectious Diseases
41(7).
p.1029-1037
- Abstract
Cutibacterium is a genus often considered a contaminant when present in blood cultures, but it can also cause severe infections, especially related to implanted foreign materials. We investigated the incidence and features of patients with true Cutibacterium infection. Patients with positive Cutibacterium blood cultures between the years 2015-2020 in southern Sweden were identified through microbiology records and medical records were studied retrospectively. Cutibacterium isolates were species determined using MALDI-TOF MS. Patients were classified as having true infection or contamination according to a definition considering both clinical and microbiological features and these groups were compared. A total of 313 episodes of positive... (More)
Cutibacterium is a genus often considered a contaminant when present in blood cultures, but it can also cause severe infections, especially related to implanted foreign materials. We investigated the incidence and features of patients with true Cutibacterium infection. Patients with positive Cutibacterium blood cultures between the years 2015-2020 in southern Sweden were identified through microbiology records and medical records were studied retrospectively. Cutibacterium isolates were species determined using MALDI-TOF MS. Patients were classified as having true infection or contamination according to a definition considering both clinical and microbiological features and these groups were compared. A total of 313 episodes of positive Cutibacterium blood cultures were identified in 312 patients. Of these, 49 (16%, corresponding to an incidence of 6 cases per million inhabitants per year) were classified as true infections. The most common species was Cutibacterium acnes (87%), and the majority were elderly men with comorbidities. Patients with true Cutibacterium infection often had an unknown focus of infection (n = 21) or a focus in the respiratory tract (n = 18). We identified one episode of ventriculo-peritoneal shunt infection, three episodes of aortic stent-graft infection, and one episode of infective endocarditis. Two patients, where Cutibacterium was isolated at the site of infection, had only one positive blood culture. The finding of positive Cutibacterium blood cultures should not always be considered contamination. Definitions of true Cutibacterium bacteremia with a demand that more than one blood culture must be positive may miss true infections.
(Less)
- author
- Boman, Jolin
; Nilson, Bo
LU
; Sunnerhagen, Torgny
LU
and Rasmussen, Magnus
LU
- organization
- publishing date
- 2022-05-25
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Clinical Microbiology and Infectious Diseases
- volume
- 41
- issue
- 7
- pages
- 1029 - 1037
- publisher
- Springer
- external identifiers
-
- scopus:85130743896
- pmid:35612767
- ISSN
- 0934-9723
- DOI
- 10.1007/s10096-022-04458-9
- project
- Matters of the heart- Biofilm on cardiovascular prostheses, their microbiological properties, and antibiotic tolerance
- language
- English
- LU publication?
- yes
- additional info
- © 2022. The Author(s).
- id
- cb62785e-0c78-4dcb-a3b3-637012d22d42
- date added to LUP
- 2022-05-27 10:41:37
- date last changed
- 2024-04-18 12:27:48
@article{cb62785e-0c78-4dcb-a3b3-637012d22d42,
abstract = {{<p>Cutibacterium is a genus often considered a contaminant when present in blood cultures, but it can also cause severe infections, especially related to implanted foreign materials. We investigated the incidence and features of patients with true Cutibacterium infection. Patients with positive Cutibacterium blood cultures between the years 2015-2020 in southern Sweden were identified through microbiology records and medical records were studied retrospectively. Cutibacterium isolates were species determined using MALDI-TOF MS. Patients were classified as having true infection or contamination according to a definition considering both clinical and microbiological features and these groups were compared. A total of 313 episodes of positive Cutibacterium blood cultures were identified in 312 patients. Of these, 49 (16%, corresponding to an incidence of 6 cases per million inhabitants per year) were classified as true infections. The most common species was Cutibacterium acnes (87%), and the majority were elderly men with comorbidities. Patients with true Cutibacterium infection often had an unknown focus of infection (n = 21) or a focus in the respiratory tract (n = 18). We identified one episode of ventriculo-peritoneal shunt infection, three episodes of aortic stent-graft infection, and one episode of infective endocarditis. Two patients, where Cutibacterium was isolated at the site of infection, had only one positive blood culture. The finding of positive Cutibacterium blood cultures should not always be considered contamination. Definitions of true Cutibacterium bacteremia with a demand that more than one blood culture must be positive may miss true infections.</p>}},
author = {{Boman, Jolin and Nilson, Bo and Sunnerhagen, Torgny and Rasmussen, Magnus}},
issn = {{0934-9723}},
language = {{eng}},
month = {{05}},
number = {{7}},
pages = {{1029--1037}},
publisher = {{Springer}},
series = {{European Journal of Clinical Microbiology and Infectious Diseases}},
title = {{True infection or contamination in patients with positive Cutibacterium blood cultures-a retrospective cohort study}},
url = {{https://lup.lub.lu.se/search/files/119234280/True_infection_or_contamination_in_patients_with_positive_Cutibacterium_blood_cultures_a_retrospective_cohort_study.pdf}},
doi = {{10.1007/s10096-022-04458-9}},
volume = {{41}},
year = {{2022}},
}