Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Impact of maternal prepregnancy body mass index on neonatal outcomes following extremely preterm birth

Girard, Charlotte ; Zeitlin, Jennifer ; Marlow, Neil ; Norman, Mikael ; Serenius, Fredrik ; Draper, Elizabeth S. ; Johnson, Samantha ; Benhammou, Valérie ; Källén, Karin LU and van Buuren, Stef , et al. (2025) In Obesity 33(3). p.599-611
Abstract

Objective: Extremes of prepregnancy maternal BMI increase neonatal mortality and morbidity at term. They also increase the risk of extremely preterm (EP, i.e., <27 weeks' gestational age) births. However, the association between maternal BMI and outcomes for EP babies is poorly understood. Methods: We used a cross-country design, bringing together the following three population-based, prospective, national EP birth cohorts: EXPRESS (Sweden, 2004–2007); EPICure 2 (UK, 2006); and EPIPAGE 2 (France, 2011). We included all singleton births at 22 to 26 weeks' gestational age with a live fetus at maternal hospital admission. Our exposure was maternal prepregnancy BMI, i.e., underweight, reference, overweight, or obesity. Odds ratios (OR)... (More)

Objective: Extremes of prepregnancy maternal BMI increase neonatal mortality and morbidity at term. They also increase the risk of extremely preterm (EP, i.e., <27 weeks' gestational age) births. However, the association between maternal BMI and outcomes for EP babies is poorly understood. Methods: We used a cross-country design, bringing together the following three population-based, prospective, national EP birth cohorts: EXPRESS (Sweden, 2004–2007); EPICure 2 (UK, 2006); and EPIPAGE 2 (France, 2011). We included all singleton births at 22 to 26 weeks' gestational age with a live fetus at maternal hospital admission. Our exposure was maternal prepregnancy BMI, i.e., underweight, reference, overweight, or obesity. Odds ratios (OR) for survival without severe neonatal morbidity to hospital discharge according to maternal BMI were calculated using logistic regression. Results: A total of 1396 babies were born to mothers in the reference group, 140 to those with underweight, 719 to those with overweight, 556 to those with obesity, and 445 to those with missing BMI information. There was no difference in survival without major neonatal morbidity (reference, 22%; underweight, 26%, OR, 1.31, 95% CI: 0.82–2.08; overweight, 23%, OR, 1.00, 95% CI: 0.77–1.29; obesity, 19%, OR, 0.94, 95% CI: 0.70–1.25). Conclusions: No associations were seen between maternal BMI and outcomes for EP babies.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Obesity
volume
33
issue
3
pages
13 pages
publisher
Nature Publishing Group
external identifiers
  • pmid:39915012
  • scopus:85217049633
ISSN
1930-7381
DOI
10.1002/oby.24241
language
English
LU publication?
yes
id
cb7a499d-c3d1-4727-ab22-99424287137f
date added to LUP
2025-05-28 09:44:02
date last changed
2025-06-11 10:32:40
@article{cb7a499d-c3d1-4727-ab22-99424287137f,
  abstract     = {{<p>Objective: Extremes of prepregnancy maternal BMI increase neonatal mortality and morbidity at term. They also increase the risk of extremely preterm (EP, i.e., &lt;27 weeks' gestational age) births. However, the association between maternal BMI and outcomes for EP babies is poorly understood. Methods: We used a cross-country design, bringing together the following three population-based, prospective, national EP birth cohorts: EXPRESS (Sweden, 2004–2007); EPICure 2 (UK, 2006); and EPIPAGE 2 (France, 2011). We included all singleton births at 22 to 26 weeks' gestational age with a live fetus at maternal hospital admission. Our exposure was maternal prepregnancy BMI, i.e., underweight, reference, overweight, or obesity. Odds ratios (OR) for survival without severe neonatal morbidity to hospital discharge according to maternal BMI were calculated using logistic regression. Results: A total of 1396 babies were born to mothers in the reference group, 140 to those with underweight, 719 to those with overweight, 556 to those with obesity, and 445 to those with missing BMI information. There was no difference in survival without major neonatal morbidity (reference, 22%; underweight, 26%, OR, 1.31, 95% CI: 0.82–2.08; overweight, 23%, OR, 1.00, 95% CI: 0.77–1.29; obesity, 19%, OR, 0.94, 95% CI: 0.70–1.25). Conclusions: No associations were seen between maternal BMI and outcomes for EP babies.</p>}},
  author       = {{Girard, Charlotte and Zeitlin, Jennifer and Marlow, Neil and Norman, Mikael and Serenius, Fredrik and Draper, Elizabeth S. and Johnson, Samantha and Benhammou, Valérie and Källén, Karin and van Buuren, Stef and Ancel, Pierre Yves and Morgan, Andrei S.}},
  issn         = {{1930-7381}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{599--611}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Obesity}},
  title        = {{Impact of maternal prepregnancy body mass index on neonatal outcomes following extremely preterm birth}},
  url          = {{http://dx.doi.org/10.1002/oby.24241}},
  doi          = {{10.1002/oby.24241}},
  volume       = {{33}},
  year         = {{2025}},
}