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Persistent elevation of fibrosis biomarker cartilage oligomeric matrix protein following hepatitis C virus eradication

Andréasson, Kristofer LU ; Jönsson, Göran LU ; Hesselstrand, Roger LU and Norrgren, Hans LU (2019) In World Journal of Hepatology 11(3). p.330-334
Abstract

Serum levels of cartilage oligomeric matrix protein (COMP) has been presented as a biomarker of liver fibrosis in several cross-sectional studies. COMP is also an essential mediator in carcinoma development and has also been associated with hepatocellular carcinoma. We present a prospective analysis of this biomarker in 38 patients with chronic hepatitis C who were subject to eradication therapy with direct acting antivirals. We confirm previous studies associating COMP elevation with liver cirrhosis. We also show how viral levels are correlated with COMP at baseline. In our prospective analysis, we report that successful eradication of hepatitis C results in improvement in liver stiffness and laboratory liver function tests at 1 year... (More)

Serum levels of cartilage oligomeric matrix protein (COMP) has been presented as a biomarker of liver fibrosis in several cross-sectional studies. COMP is also an essential mediator in carcinoma development and has also been associated with hepatocellular carcinoma. We present a prospective analysis of this biomarker in 38 patients with chronic hepatitis C who were subject to eradication therapy with direct acting antivirals. We confirm previous studies associating COMP elevation with liver cirrhosis. We also show how viral levels are correlated with COMP at baseline. In our prospective analysis, we report that successful eradication of hepatitis C results in improvement in liver stiffness and laboratory liver function tests at 1 year follow-up. In contrast, median COMP-levels remain unchanged during the study period. We conclude that the biomarker potential of COMP in the prospective evaluation of liver diseases, remains to be elucidated.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cartilage oligomeric matrix protein, Chronic, Fibrosis, Hepatitis C
in
World Journal of Hepatology
volume
11
issue
3
pages
5 pages
publisher
Baishideng Publishing Group
external identifiers
  • scopus:85063677835
DOI
10.4254/wjh.v11.i3.330
language
English
LU publication?
yes
id
cbb231af-314c-426f-a365-be9a33bf1a6f
date added to LUP
2019-04-10 10:50:57
date last changed
2019-05-08 02:30:24
@article{cbb231af-314c-426f-a365-be9a33bf1a6f,
  abstract     = {<p>Serum levels of cartilage oligomeric matrix protein (COMP) has been presented as a biomarker of liver fibrosis in several cross-sectional studies. COMP is also an essential mediator in carcinoma development and has also been associated with hepatocellular carcinoma. We present a prospective analysis of this biomarker in 38 patients with chronic hepatitis C who were subject to eradication therapy with direct acting antivirals. We confirm previous studies associating COMP elevation with liver cirrhosis. We also show how viral levels are correlated with COMP at baseline. In our prospective analysis, we report that successful eradication of hepatitis C results in improvement in liver stiffness and laboratory liver function tests at 1 year follow-up. In contrast, median COMP-levels remain unchanged during the study period. We conclude that the biomarker potential of COMP in the prospective evaluation of liver diseases, remains to be elucidated.</p>},
  author       = {Andréasson, Kristofer and Jönsson, Göran and Hesselstrand, Roger and Norrgren, Hans},
  keyword      = {Cartilage oligomeric matrix protein,Chronic,Fibrosis,Hepatitis C},
  language     = {eng},
  number       = {3},
  pages        = {330--334},
  publisher    = {Baishideng Publishing Group},
  series       = {World Journal of Hepatology},
  title        = {Persistent elevation of fibrosis biomarker cartilage oligomeric matrix protein following hepatitis C virus eradication},
  url          = {http://dx.doi.org/10.4254/wjh.v11.i3.330},
  volume       = {11},
  year         = {2019},
}