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Bayesian determination of the effect of a deep eutectic solvent on the structure of lipid monolayers

McCluskey, Andrew R. ; Sanchez-Fernandez, Adrian LU ; Edler, Karen J. LU ; Parker, Stephen C. ; Jackson, Andrew J. LU ; Campbell, Richard A. LU and Arnold, Thomas (2019) In Physical Chemistry Chemical Physics 21(11). p.6133-6141
Abstract

In this work, we present the first example of the self-assembly of phospholipid monolayers at the interface between air and an ionic solvent. Deep eutectic solvents are a novel class of environmentally friendly, non-aqueous, room temperature liquids with tunable properties, that have wide-ranging potential applications and are capable of promoting the self-assembly of surfactant molecules. We use a chemically-consistent Bayesian modelling of X-ray and neutron reflectometry measurements to show that these monolayers broadly behave as they do on water. This method allows for the monolayer structure to be determined, alongside the molecular volumes of the individual monolayer components, without the need for water-specific constraints to... (More)

In this work, we present the first example of the self-assembly of phospholipid monolayers at the interface between air and an ionic solvent. Deep eutectic solvents are a novel class of environmentally friendly, non-aqueous, room temperature liquids with tunable properties, that have wide-ranging potential applications and are capable of promoting the self-assembly of surfactant molecules. We use a chemically-consistent Bayesian modelling of X-ray and neutron reflectometry measurements to show that these monolayers broadly behave as they do on water. This method allows for the monolayer structure to be determined, alongside the molecular volumes of the individual monolayer components, without the need for water-specific constraints to be introduced. Furthermore, using this method we are able to better understand the correlations present between parameters in the analytical model. This example of a non-aqueous phospholipid monolayer has important implications for the potential uses of these solvents and for our understanding of how biomolecules behave in the absence of water.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physical Chemistry Chemical Physics
volume
21
issue
11
pages
9 pages
publisher
Royal Society of Chemistry
external identifiers
  • pmid:30816891
  • scopus:85062888640
ISSN
1463-9076
DOI
10.1039/c9cp00203k
language
English
LU publication?
yes
id
cbd9a384-c00f-4cdb-9434-cf75642632b1
date added to LUP
2019-03-29 12:33:00
date last changed
2020-10-20 04:53:30
@article{cbd9a384-c00f-4cdb-9434-cf75642632b1,
  abstract     = {<p>In this work, we present the first example of the self-assembly of phospholipid monolayers at the interface between air and an ionic solvent. Deep eutectic solvents are a novel class of environmentally friendly, non-aqueous, room temperature liquids with tunable properties, that have wide-ranging potential applications and are capable of promoting the self-assembly of surfactant molecules. We use a chemically-consistent Bayesian modelling of X-ray and neutron reflectometry measurements to show that these monolayers broadly behave as they do on water. This method allows for the monolayer structure to be determined, alongside the molecular volumes of the individual monolayer components, without the need for water-specific constraints to be introduced. Furthermore, using this method we are able to better understand the correlations present between parameters in the analytical model. This example of a non-aqueous phospholipid monolayer has important implications for the potential uses of these solvents and for our understanding of how biomolecules behave in the absence of water.</p>},
  author       = {McCluskey, Andrew R. and Sanchez-Fernandez, Adrian and Edler, Karen J. and Parker, Stephen C. and Jackson, Andrew J. and Campbell, Richard A. and Arnold, Thomas},
  issn         = {1463-9076},
  language     = {eng},
  number       = {11},
  pages        = {6133--6141},
  publisher    = {Royal Society of Chemistry},
  series       = {Physical Chemistry Chemical Physics},
  title        = {Bayesian determination of the effect of a deep eutectic solvent on the structure of lipid monolayers},
  url          = {http://dx.doi.org/10.1039/c9cp00203k},
  doi          = {10.1039/c9cp00203k},
  volume       = {21},
  year         = {2019},
}