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Changes in bone mineral density over 10 years in patients with early rheumatoid arthritis

Theander, Lisa LU ; Willim, Minna LU ; Nilsson, Jan Åke LU ; Karlsson, Magnus LU ; Åkesson, Kristina E. LU ; Jacobsson, Lennart T.H. LU and Turesson, Carl LU (2020) In RMD Open 6(1).
Abstract

Objectives To investigate changes in bone mineral density (BMD) in patients with early rheumatoid arthritis (RA) over a 10-year period. Methods Consecutive patients with early RA (symptom duration <12 months) were followed according to a structured programme and examined with dual-energy X-ray absorptiometry (DXA) at inclusion and after 2, 5 and 10 years. Mean Z-scores over the study period were estimated using mixed linear effect models. Changes in Z-scores between follow-up visits were analysed using paired T-tests. Results At inclusion, 220 patients were examined with DXA. At the femoral neck, the mean Z-score over 10 years was -0.33 (95 % CI -0.57 to -0.08) in men and -0.07 (-0.22 to 0.08) in women. Men had significantly lower... (More)

Objectives To investigate changes in bone mineral density (BMD) in patients with early rheumatoid arthritis (RA) over a 10-year period. Methods Consecutive patients with early RA (symptom duration <12 months) were followed according to a structured programme and examined with dual-energy X-ray absorptiometry (DXA) at inclusion and after 2, 5 and 10 years. Mean Z-scores over the study period were estimated using mixed linear effect models. Changes in Z-scores between follow-up visits were analysed using paired T-tests. Results At inclusion, 220 patients were examined with DXA. At the femoral neck, the mean Z-score over 10 years was -0.33 (95 % CI -0.57 to -0.08) in men and -0.07 (-0.22 to 0.08) in women. Men had significantly lower BMD at the femoral neck than expected by age at inclusion (intercept Z-score value -0.35; 95 % CI -0.61 to -0.09), whereas there was no such difference in women. At the lumbar spine, the mean Z-score over the study period for men was -0.05 (-0.29 to 0.19) and for women 0.06 (-0.10 to 0.21). In paired comparisons of BMD at different follow-up visits, femoral neck Z-scores for men decreased significantly from inclusion to the 5-year follow-up. After 5 years, no further reduction was seen. Conclusions In this observational study of a limited sample, men with early RA had reduced femoral neck BMD at diagnosis, with a further significant but marginal decline during the first 5 years. Lumbar spine BMD Z-scores were not reduced in men or women with early RA. Data on 10-year follow-up were limited.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bone mineral density, osteoporosis, rheumatoid arthritis (RA)
in
RMD Open
volume
6
issue
1
article number
e001142
publisher
BMJ Publishing Group
external identifiers
  • pmid:32519976
  • scopus:85079647829
ISSN
2056-5933
DOI
10.1136/rmdopen-2019-001142
language
English
LU publication?
yes
id
cbdb87ad-dced-4c23-bcab-8d64246c0b45
date added to LUP
2020-03-10 11:17:49
date last changed
2024-05-01 06:36:08
@article{cbdb87ad-dced-4c23-bcab-8d64246c0b45,
  abstract     = {{<p>Objectives To investigate changes in bone mineral density (BMD) in patients with early rheumatoid arthritis (RA) over a 10-year period. Methods Consecutive patients with early RA (symptom duration &lt;12 months) were followed according to a structured programme and examined with dual-energy X-ray absorptiometry (DXA) at inclusion and after 2, 5 and 10 years. Mean Z-scores over the study period were estimated using mixed linear effect models. Changes in Z-scores between follow-up visits were analysed using paired T-tests. Results At inclusion, 220 patients were examined with DXA. At the femoral neck, the mean Z-score over 10 years was -0.33 (95 % CI -0.57 to -0.08) in men and -0.07 (-0.22 to 0.08) in women. Men had significantly lower BMD at the femoral neck than expected by age at inclusion (intercept Z-score value -0.35; 95 % CI -0.61 to -0.09), whereas there was no such difference in women. At the lumbar spine, the mean Z-score over the study period for men was -0.05 (-0.29 to 0.19) and for women 0.06 (-0.10 to 0.21). In paired comparisons of BMD at different follow-up visits, femoral neck Z-scores for men decreased significantly from inclusion to the 5-year follow-up. After 5 years, no further reduction was seen. Conclusions In this observational study of a limited sample, men with early RA had reduced femoral neck BMD at diagnosis, with a further significant but marginal decline during the first 5 years. Lumbar spine BMD Z-scores were not reduced in men or women with early RA. Data on 10-year follow-up were limited.</p>}},
  author       = {{Theander, Lisa and Willim, Minna and Nilsson, Jan Åke and Karlsson, Magnus and Åkesson, Kristina E. and Jacobsson, Lennart T.H. and Turesson, Carl}},
  issn         = {{2056-5933}},
  keywords     = {{bone mineral density; osteoporosis; rheumatoid arthritis (RA)}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{RMD Open}},
  title        = {{Changes in bone mineral density over 10 years in patients with early rheumatoid arthritis}},
  url          = {{http://dx.doi.org/10.1136/rmdopen-2019-001142}},
  doi          = {{10.1136/rmdopen-2019-001142}},
  volume       = {{6}},
  year         = {{2020}},
}