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Interactive roles of the cerebellum and striatum in sub-second and supra-second timing : Support for an initiation, continuation, adjustment, and termination (ICAT) model of temporal processing

Petter, Elijah A.; Lusk, Nicholas A.; Hesslow, Germund LU and Meck, Warren H. (2016) In Neuroscience and Biobehavioral Reviews 71. p.739-755
Abstract

The contributions of cortico-cerebellar and cortico-striatal circuits to timing and time perception have often been a point of contention. In this review we propose that the cerebellum principally functions to reduce variability, through the detection of stimulus onsets and the sub-division of longer durations, thus contributing to both sub-second and supra-second timing. This sensitivity of the cerebellum to stimulus dynamics and subsequent integration with motor control allows it to accurately measure intervals within a range of 100–2000 ms. For intervals in the supra-second range (e.g., >2000 ms), we propose that cerebellar output signals from the dentate nucleus pass through thalamic connections to the striatum, where... (More)

The contributions of cortico-cerebellar and cortico-striatal circuits to timing and time perception have often been a point of contention. In this review we propose that the cerebellum principally functions to reduce variability, through the detection of stimulus onsets and the sub-division of longer durations, thus contributing to both sub-second and supra-second timing. This sensitivity of the cerebellum to stimulus dynamics and subsequent integration with motor control allows it to accurately measure intervals within a range of 100–2000 ms. For intervals in the supra-second range (e.g., >2000 ms), we propose that cerebellar output signals from the dentate nucleus pass through thalamic connections to the striatum, where cortico-thalamic-striatal circuits supporting higher-level cognitive functions take over. Moreover, the importance of intrinsic circuit dynamics as well as behavioral, neuroimaging, and lesion studies of the cerebellum and striatum are discussed in terms of a framework positing initiation, continuation, adjustment, and termination phases of temporal processing.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Degeneracy, Interval timing, Medium spiny neurons, Neural oscillations, Purkinje cells, Striatal beat-frequency model, Time perception
in
Neuroscience and Biobehavioral Reviews
volume
71
pages
17 pages
publisher
Elsevier
external identifiers
  • scopus:84994381606
  • wos:000390502100049
ISSN
0149-7634
DOI
10.1016/j.neubiorev.2016.10.015
language
English
LU publication?
yes
id
cc157dd3-84a8-4dfa-be04-311505196959
date added to LUP
2016-11-25 08:11:39
date last changed
2017-10-08 04:55:06
@article{cc157dd3-84a8-4dfa-be04-311505196959,
  abstract     = {<p>The contributions of cortico-cerebellar and cortico-striatal circuits to timing and time perception have often been a point of contention. In this review we propose that the cerebellum principally functions to reduce variability, through the detection of stimulus onsets and the sub-division of longer durations, thus contributing to both sub-second and supra-second timing. This sensitivity of the cerebellum to stimulus dynamics and subsequent integration with motor control allows it to accurately measure intervals within a range of 100–2000 ms. For intervals in the supra-second range (e.g., &gt;2000 ms), we propose that cerebellar output signals from the dentate nucleus pass through thalamic connections to the striatum, where cortico-thalamic-striatal circuits supporting higher-level cognitive functions take over. Moreover, the importance of intrinsic circuit dynamics as well as behavioral, neuroimaging, and lesion studies of the cerebellum and striatum are discussed in terms of a framework positing initiation, continuation, adjustment, and termination phases of temporal processing.</p>},
  author       = {Petter, Elijah A. and Lusk, Nicholas A. and Hesslow, Germund and Meck, Warren H.},
  issn         = {0149-7634},
  keyword      = {Degeneracy,Interval timing,Medium spiny neurons,Neural oscillations,Purkinje cells,Striatal beat-frequency model,Time perception},
  language     = {eng},
  month        = {12},
  pages        = {739--755},
  publisher    = {Elsevier},
  series       = {Neuroscience and Biobehavioral Reviews},
  title        = {Interactive roles of the cerebellum and striatum in sub-second and supra-second timing : Support for an initiation, continuation, adjustment, and termination (ICAT) model of temporal processing},
  url          = {http://dx.doi.org/10.1016/j.neubiorev.2016.10.015},
  volume       = {71},
  year         = {2016},
}