Interactive roles of the cerebellum and striatum in sub-second and supra-second timing : Support for an initiation, continuation, adjustment, and termination (ICAT) model of temporal processing
(2016) In Neuroscience and Biobehavioral Reviews 71. p.739-755- Abstract
The contributions of cortico-cerebellar and cortico-striatal circuits to timing and time perception have often been a point of contention. In this review we propose that the cerebellum principally functions to reduce variability, through the detection of stimulus onsets and the sub-division of longer durations, thus contributing to both sub-second and supra-second timing. This sensitivity of the cerebellum to stimulus dynamics and subsequent integration with motor control allows it to accurately measure intervals within a range of 100–2000 ms. For intervals in the supra-second range (e.g., >2000 ms), we propose that cerebellar output signals from the dentate nucleus pass through thalamic connections to the striatum, where... (More)
The contributions of cortico-cerebellar and cortico-striatal circuits to timing and time perception have often been a point of contention. In this review we propose that the cerebellum principally functions to reduce variability, through the detection of stimulus onsets and the sub-division of longer durations, thus contributing to both sub-second and supra-second timing. This sensitivity of the cerebellum to stimulus dynamics and subsequent integration with motor control allows it to accurately measure intervals within a range of 100–2000 ms. For intervals in the supra-second range (e.g., >2000 ms), we propose that cerebellar output signals from the dentate nucleus pass through thalamic connections to the striatum, where cortico-thalamic-striatal circuits supporting higher-level cognitive functions take over. Moreover, the importance of intrinsic circuit dynamics as well as behavioral, neuroimaging, and lesion studies of the cerebellum and striatum are discussed in terms of a framework positing initiation, continuation, adjustment, and termination phases of temporal processing.
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- author
- Petter, Elijah A. ; Lusk, Nicholas A. ; Hesslow, Germund LU and Meck, Warren H.
- organization
- publishing date
- 2016-12-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Degeneracy, Interval timing, Medium spiny neurons, Neural oscillations, Purkinje cells, Striatal beat-frequency model, Time perception
- in
- Neuroscience and Biobehavioral Reviews
- volume
- 71
- pages
- 17 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:27773690
- wos:000390502100049
- scopus:84994381606
- ISSN
- 0149-7634
- DOI
- 10.1016/j.neubiorev.2016.10.015
- language
- English
- LU publication?
- yes
- id
- cc157dd3-84a8-4dfa-be04-311505196959
- date added to LUP
- 2016-11-25 08:11:39
- date last changed
- 2024-12-01 12:46:47
@article{cc157dd3-84a8-4dfa-be04-311505196959,
abstract = {{<p>The contributions of cortico-cerebellar and cortico-striatal circuits to timing and time perception have often been a point of contention. In this review we propose that the cerebellum principally functions to reduce variability, through the detection of stimulus onsets and the sub-division of longer durations, thus contributing to both sub-second and supra-second timing. This sensitivity of the cerebellum to stimulus dynamics and subsequent integration with motor control allows it to accurately measure intervals within a range of 100–2000 ms. For intervals in the supra-second range (e.g., >2000 ms), we propose that cerebellar output signals from the dentate nucleus pass through thalamic connections to the striatum, where cortico-thalamic-striatal circuits supporting higher-level cognitive functions take over. Moreover, the importance of intrinsic circuit dynamics as well as behavioral, neuroimaging, and lesion studies of the cerebellum and striatum are discussed in terms of a framework positing initiation, continuation, adjustment, and termination phases of temporal processing.</p>}},
author = {{Petter, Elijah A. and Lusk, Nicholas A. and Hesslow, Germund and Meck, Warren H.}},
issn = {{0149-7634}},
keywords = {{Degeneracy; Interval timing; Medium spiny neurons; Neural oscillations; Purkinje cells; Striatal beat-frequency model; Time perception}},
language = {{eng}},
month = {{12}},
pages = {{739--755}},
publisher = {{Elsevier}},
series = {{Neuroscience and Biobehavioral Reviews}},
title = {{Interactive roles of the cerebellum and striatum in sub-second and supra-second timing : Support for an initiation, continuation, adjustment, and termination (ICAT) model of temporal processing}},
url = {{http://dx.doi.org/10.1016/j.neubiorev.2016.10.015}},
doi = {{10.1016/j.neubiorev.2016.10.015}},
volume = {{71}},
year = {{2016}},
}