Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Fetal electrocardiographic monitoring during labor in relation to cord blood levels of the brain-injury marker protein S-100.

Stuart, Andrea ; Edvinsson, Linda ; Källén, Karin LU ; Olofsson, Per LU ; Hellsten, Charlotte LU and Amer-Wåhlin, Isis LU (2008) In Journal of Perinatal Medicine 36(2). p.136-141
Abstract
Abstract Background: Cord artery protein S-100 levels at birth are potential markers of brain damage after asphyxia. Our aim was to investigate if S-100 levels were elevated in neonates with indirect signs of asphyxia during birth. S-100 levels in cord blood were studied in relation to cardiotocography (CTG) and fetal electrocardiography (FECG) changes during birth and to acidemia in umbilical blood. Material and methods: This case-control study was performed in parallel to a large randomized controlled trial (RCT) studying FECG at birth. Protein S-100 samples were collected from 103 neonates at birth and related to the CTG and ECG changes during labor and to pH in umbilical blood. Results: Protein S-100 was significantly higher in... (More)
Abstract Background: Cord artery protein S-100 levels at birth are potential markers of brain damage after asphyxia. Our aim was to investigate if S-100 levels were elevated in neonates with indirect signs of asphyxia during birth. S-100 levels in cord blood were studied in relation to cardiotocography (CTG) and fetal electrocardiography (FECG) changes during birth and to acidemia in umbilical blood. Material and methods: This case-control study was performed in parallel to a large randomized controlled trial (RCT) studying FECG at birth. Protein S-100 samples were collected from 103 neonates at birth and related to the CTG and ECG changes during labor and to pH in umbilical blood. Results: Protein S-100 was significantly higher in neonates with umbilical artery blood pH</=7.05, compared to neonates with pH>7.05. Furthermore, neonates with preterminal CTG patterns showed increased S-100 levels compared to neonates with normal CTG. Neonates having significant CTG and ECG changes, leading to intervention according to clinical guidelines, showed significantly higher S-100 levels compared to neonates without such indication of intervention. Conclusion: A relation exists between S-100 in umbilical blood at birth, acidosis and pathological patterns in CTG and FECG during labor. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Perinatal Medicine
volume
36
issue
2
pages
136 - 141
publisher
De Gruyter
external identifiers
  • pmid:18331207
  • wos:000254578700007
  • scopus:40549137464
  • pmid:18331207
ISSN
1619-3997
DOI
10.1515/JPM.2008.019
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Reproductive Epidemiology/Tornblad Institute (013003000), Research Unit for Urogynaecology and Reproductive Pharmacology (013242710), Department of Obstetrics and Gynaecology (Lund) (013018000)
id
cd32a658-4178-48b0-92fd-3e7a05cb9e0e (old id 1052673)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18331207?dopt=Abstract
date added to LUP
2016-04-04 08:54:32
date last changed
2022-01-29 07:34:16
@article{cd32a658-4178-48b0-92fd-3e7a05cb9e0e,
  abstract     = {{Abstract Background: Cord artery protein S-100 levels at birth are potential markers of brain damage after asphyxia. Our aim was to investigate if S-100 levels were elevated in neonates with indirect signs of asphyxia during birth. S-100 levels in cord blood were studied in relation to cardiotocography (CTG) and fetal electrocardiography (FECG) changes during birth and to acidemia in umbilical blood. Material and methods: This case-control study was performed in parallel to a large randomized controlled trial (RCT) studying FECG at birth. Protein S-100 samples were collected from 103 neonates at birth and related to the CTG and ECG changes during labor and to pH in umbilical blood. Results: Protein S-100 was significantly higher in neonates with umbilical artery blood pH&lt;/=7.05, compared to neonates with pH&gt;7.05. Furthermore, neonates with preterminal CTG patterns showed increased S-100 levels compared to neonates with normal CTG. Neonates having significant CTG and ECG changes, leading to intervention according to clinical guidelines, showed significantly higher S-100 levels compared to neonates without such indication of intervention. Conclusion: A relation exists between S-100 in umbilical blood at birth, acidosis and pathological patterns in CTG and FECG during labor.}},
  author       = {{Stuart, Andrea and Edvinsson, Linda and Källén, Karin and Olofsson, Per and Hellsten, Charlotte and Amer-Wåhlin, Isis}},
  issn         = {{1619-3997}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{136--141}},
  publisher    = {{De Gruyter}},
  series       = {{Journal of Perinatal Medicine}},
  title        = {{Fetal electrocardiographic monitoring during labor in relation to cord blood levels of the brain-injury marker protein S-100.}},
  url          = {{http://dx.doi.org/10.1515/JPM.2008.019}},
  doi          = {{10.1515/JPM.2008.019}},
  volume       = {{36}},
  year         = {{2008}},
}