The population impact of familial cancer, a major cause of cancer
Frank, Christoph LU ; Fallah, Mahdi LU ; Ji, Jianguang LU
; Sundquist, Jan
LU
and Hemminki, Kari
LU
(2014)
In International Journal of Cancer
134(8).
p.906-1899
- Abstract
The population attributable fraction (PAF) defines the proportion of a disease that would be prevented if the exposure to a particular risk factor was avoided. Familial risk is a known risk factor for many cancers, but an unbiased estimation of the PAF for familial risk requires a large study population to include rare cancers. PAFs and their corresponding standardized incidence ratios (SIRs) were calculated for familial relative risk among first-degree relatives (FDRs) and second-degree relatives (SDRs) diagnosed with the same (concordant) invasive or in situ cancers. Calculations were based on the Swedish Family-Cancer Database considering 8,148,737 individuals. To assess environmental effects, PAFs were also calculated for concordant... (More)
The population attributable fraction (PAF) defines the proportion of a disease that would be prevented if the exposure to a particular risk factor was avoided. Familial risk is a known risk factor for many cancers, but an unbiased estimation of the PAF for familial risk requires a large study population to include rare cancers. PAFs and their corresponding standardized incidence ratios (SIRs) were calculated for familial relative risk among first-degree relatives (FDRs) and second-degree relatives (SDRs) diagnosed with the same (concordant) invasive or in situ cancers. Calculations were based on the Swedish Family-Cancer Database considering 8,148,737 individuals. To assess environmental effects, PAFs were also calculated for concordant cancers among spouses. Almost all cancers showed a significant familial risk. The highest PAFs were found for the common cancers of the prostate (13.94%), breast (7.46%) and colorectum (6.78%) among the FDRs. In the FDRs, the overall PAF for any concordant cancer was 4.20%, but in the SDRs, it was only 0.34%. The overall PAFs for in situ cancers were 0.86% and 0.56% for the FDRs and SDRs, respectively. The overall independent familial PAF was 5.96% for the invasive and in situ cancers in the FDRs and SDRs. The cancers between spouses yielded an overall PAF of 0.14%. For esophageal cancer, the risk among spouses was higher than the familial risk. Our study shows that the overall familial PAF of 5.96%, although underestimated for sex-specific cancers, ranks as the third most common population burden after tobacco smoking and unhealthy diet.
(Less)
- author
- Frank, Christoph
LU
; Fallah, Mahdi
LU
; Ji, Jianguang
LU
; Sundquist, Jan
LU
and Hemminki, Kari
LU
- organization
- publishing date
- 2014-04-15
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Breast Neoplasms/epidemiology, Carcinoma in Situ/epidemiology, Colorectal Neoplasms/epidemiology, Esophageal Neoplasms/epidemiology, Family, Female, Humans, Incidence, Male, Prostatic Neoplasms/epidemiology, Risk, Risk Factors
- in
- International Journal of Cancer
- volume
- 134
- issue
- 8
- pages
- 8 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:24590453
- scopus:84893763066
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.28510
- language
- English
- LU publication?
- yes
- id
- cd53d280-f918-403d-9cdf-27ce4d4cf30f
- date added to LUP
- 2019-01-30 10:53:39
- date last changed
- 2024-03-19 00:10:58
@article{cd53d280-f918-403d-9cdf-27ce4d4cf30f,
abstract = {{<p>The population attributable fraction (PAF) defines the proportion of a disease that would be prevented if the exposure to a particular risk factor was avoided. Familial risk is a known risk factor for many cancers, but an unbiased estimation of the PAF for familial risk requires a large study population to include rare cancers. PAFs and their corresponding standardized incidence ratios (SIRs) were calculated for familial relative risk among first-degree relatives (FDRs) and second-degree relatives (SDRs) diagnosed with the same (concordant) invasive or in situ cancers. Calculations were based on the Swedish Family-Cancer Database considering 8,148,737 individuals. To assess environmental effects, PAFs were also calculated for concordant cancers among spouses. Almost all cancers showed a significant familial risk. The highest PAFs were found for the common cancers of the prostate (13.94%), breast (7.46%) and colorectum (6.78%) among the FDRs. In the FDRs, the overall PAF for any concordant cancer was 4.20%, but in the SDRs, it was only 0.34%. The overall PAFs for in situ cancers were 0.86% and 0.56% for the FDRs and SDRs, respectively. The overall independent familial PAF was 5.96% for the invasive and in situ cancers in the FDRs and SDRs. The cancers between spouses yielded an overall PAF of 0.14%. For esophageal cancer, the risk among spouses was higher than the familial risk. Our study shows that the overall familial PAF of 5.96%, although underestimated for sex-specific cancers, ranks as the third most common population burden after tobacco smoking and unhealthy diet. </p>}},
author = {{Frank, Christoph and Fallah, Mahdi and Ji, Jianguang and Sundquist, Jan and Hemminki, Kari}},
issn = {{0020-7136}},
keywords = {{Breast Neoplasms/epidemiology; Carcinoma in Situ/epidemiology; Colorectal Neoplasms/epidemiology; Esophageal Neoplasms/epidemiology; Family; Female; Humans; Incidence; Male; Prostatic Neoplasms/epidemiology; Risk; Risk Factors}},
language = {{eng}},
month = {{04}},
number = {{8}},
pages = {{906--1899}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Cancer}},
title = {{The population impact of familial cancer, a major cause of cancer}},
url = {{http://dx.doi.org/10.1002/ijc.28510}},
doi = {{10.1002/ijc.28510}},
volume = {{134}},
year = {{2014}},
}