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Cognitive abnormalities and cerebral perfusion defects in a community-dwelling cohort of elderly men with MMSE within the normal range

André-Petersson, Lena LU ; Thorsson, Ola LU and Siennicki-Lantz, Arkadiusz LU (2018) In Aging, Neuropsychology, and Cognition 25(2). p.200-212
Abstract

Objectives: Mini Mental State Examination’s (MMSE’s) sensitivity in its upper level is questioned, hence we investigated cognitive abnormalities and defects in regional cerebral blood flow (rCBF) in elderly with MMSE scores ≥24. Methods: One hundred and four men at age 81 with MMSE scores ≥24 (mean 28.4 ± 1.7), no dementia or stroke, were examined with neuropsychological test battery, and their rCBF was estimated using 99mTc-HMPAO SPECT. Results: MMSE was very sparsely correlated with rCBF. Instead, visuo-spatial tests were correlated with rCBF in parietal and occipital lobe, verbal tests with rCBF in frontal and temporal-parietal lobes, and most of all between Digit Symbol and all rCBF regions, especially in subcortical gray... (More)

Objectives: Mini Mental State Examination’s (MMSE’s) sensitivity in its upper level is questioned, hence we investigated cognitive abnormalities and defects in regional cerebral blood flow (rCBF) in elderly with MMSE scores ≥24. Methods: One hundred and four men at age 81 with MMSE scores ≥24 (mean 28.4 ± 1.7), no dementia or stroke, were examined with neuropsychological test battery, and their rCBF was estimated using 99mTc-HMPAO SPECT. Results: MMSE was very sparsely correlated with rCBF. Instead, visuo-spatial tests were correlated with rCBF in parietal and occipital lobe, verbal tests with rCBF in frontal and temporal-parietal lobes, and most of all between Digit Symbol and all rCBF regions, especially in subcortical gray and white matter. In a cluster of low achievers, test of Synonyms, followed by Digit Symbol and Benton test, had highest discriminatory importance. Low achievers had generalized rCBF changes especially in subcortical areas. Only lower scores on two MMSE items, figure drawing and calculation, could discriminate the clusters. Conclusion: A substantial number of octogenarian men with MMSE ≥ 24p have widespread rCBF changes corresponding to a decreased speeded performance and verbal capacity.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
aged, 80 and over, cohort studies, emission-computed, single-photon, Neuropsychological tests, tomography
in
Aging, Neuropsychology, and Cognition
volume
25
issue
2
pages
200 - 212
publisher
Taylor & Francis
external identifiers
  • scopus:85009177524
ISSN
1382-5585
DOI
10.1080/13825585.2016.1277970
language
English
LU publication?
yes
id
cd86377b-e39f-4dcf-af57-e7d105348f93
date added to LUP
2017-02-10 14:46:19
date last changed
2018-01-29 12:29:07
@article{cd86377b-e39f-4dcf-af57-e7d105348f93,
  abstract     = {<p>Objectives: Mini Mental State Examination’s (MMSE’s) sensitivity in its upper level is questioned, hence we investigated cognitive abnormalities and defects in regional cerebral blood flow (rCBF) in elderly with MMSE scores ≥24. Methods: One hundred and four men at age 81 with MMSE scores ≥24 (mean 28.4 ± 1.7), no dementia or stroke, were examined with neuropsychological test battery, and their rCBF was estimated using <sup>99mTc</sup>-HMPAO SPECT. Results: MMSE was very sparsely correlated with rCBF. Instead, visuo-spatial tests were correlated with rCBF in parietal and occipital lobe, verbal tests with rCBF in frontal and temporal-parietal lobes, and most of all between Digit Symbol and all rCBF regions, especially in subcortical gray and white matter. In a cluster of low achievers, test of Synonyms, followed by Digit Symbol and Benton test, had highest discriminatory importance. Low achievers had generalized rCBF changes especially in subcortical areas. Only lower scores on two MMSE items, figure drawing and calculation, could discriminate the clusters. Conclusion: A substantial number of octogenarian men with MMSE ≥ 24p have widespread rCBF changes corresponding to a decreased speeded performance and verbal capacity.</p>},
  author       = {André-Petersson, Lena and Thorsson, Ola and Siennicki-Lantz, Arkadiusz},
  issn         = {1382-5585},
  keyword      = {aged, 80 and over,cohort studies,emission-computed, single-photon,Neuropsychological tests,tomography},
  language     = {eng},
  number       = {2},
  pages        = {200--212},
  publisher    = {Taylor & Francis},
  series       = {Aging, Neuropsychology, and Cognition},
  title        = {Cognitive abnormalities and cerebral perfusion defects in a community-dwelling cohort of elderly men with MMSE within the normal range},
  url          = {http://dx.doi.org/10.1080/13825585.2016.1277970},
  volume       = {25},
  year         = {2018},
}