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Abolished angiogenicity and tumorigenicity of Burkitt lymphoma by interleukin-10

Cervenak, L ; Morbidelli, L ; Donati, D ; Donnini, S ; Kambayashi, T ; Wilson, J L ; Axelson, H LU ; Castaños-Velez, E ; Ljunggren, H G and Malefyt, R D , et al. (2000) In Blood 96(7). p.73-2568
Abstract

Because of its immunosuppressive properties, interleukin-10 (IL-10) is thought to play an important role in a number of human disease states, including inflammation, autoimmunity, and transplant rejection. In this study, we demonstrate that introduction of human or viral IL-10 genes into Burkitt's lymphoma cells markedly reduced their ability to grow as subcutaneous (sc) tumors in SCID mice. In vivo assays for angiogenesis revealed an inhibition of the angiogenic capacity of the IL-10-transfected lines. Recombinant human IL-10 abolished and viral IL-10 reduced vascular endothelial growth factor (VEGF)-165-induced neovascularization. Furthermore, IL-10 blocked the VEGF- and fibroblast growth factor (FGF)-2-induced proliferation of... (More)

Because of its immunosuppressive properties, interleukin-10 (IL-10) is thought to play an important role in a number of human disease states, including inflammation, autoimmunity, and transplant rejection. In this study, we demonstrate that introduction of human or viral IL-10 genes into Burkitt's lymphoma cells markedly reduced their ability to grow as subcutaneous (sc) tumors in SCID mice. In vivo assays for angiogenesis revealed an inhibition of the angiogenic capacity of the IL-10-transfected lines. Recombinant human IL-10 abolished and viral IL-10 reduced vascular endothelial growth factor (VEGF)-165-induced neovascularization. Furthermore, IL-10 blocked the VEGF- and fibroblast growth factor (FGF)-2-induced proliferation of microvascular endothelial cells in vitro. The current observations suggest a direct role for IL-10 in the prevention of angiogenesis in human lymphoid malignancies.

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Contribution to journal
publication status
published
subject
keywords
Animals, Burkitt Lymphoma, Cell Division, Cell Line, Endothelial Growth Factors, Endothelium, Vascular, Fibroblast Growth Factor 2, Gene Expression, Interleukin-10, Killer Cells, Natural, Lymphokines, Mice, Mice, SCID, Neoplasm Transplantation, Neovascularization, Pathologic, Rabbits, Recombinant Proteins, Transfection, Tumor Cells, Cultured, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors
in
Blood
volume
96
issue
7
pages
6 pages
publisher
American Society of Hematology
external identifiers
  • pmid:11001913
  • scopus:0034307688
ISSN
0006-4971
language
English
LU publication?
yes
id
cda66bcc-fb86-41d8-bcbf-94690920a573
date added to LUP
2016-08-09 09:08:45
date last changed
2024-11-16 04:55:48
@article{cda66bcc-fb86-41d8-bcbf-94690920a573,
  abstract     = {{<p>Because of its immunosuppressive properties, interleukin-10 (IL-10) is thought to play an important role in a number of human disease states, including inflammation, autoimmunity, and transplant rejection. In this study, we demonstrate that introduction of human or viral IL-10 genes into Burkitt's lymphoma cells markedly reduced their ability to grow as subcutaneous (sc) tumors in SCID mice. In vivo assays for angiogenesis revealed an inhibition of the angiogenic capacity of the IL-10-transfected lines. Recombinant human IL-10 abolished and viral IL-10 reduced vascular endothelial growth factor (VEGF)-165-induced neovascularization. Furthermore, IL-10 blocked the VEGF- and fibroblast growth factor (FGF)-2-induced proliferation of microvascular endothelial cells in vitro. The current observations suggest a direct role for IL-10 in the prevention of angiogenesis in human lymphoid malignancies.</p>}},
  author       = {{Cervenak, L and Morbidelli, L and Donati, D and Donnini, S and Kambayashi, T and Wilson, J L and Axelson, H and Castaños-Velez, E and Ljunggren, H G and Malefyt, R D and Granger, H J and Ziche, M and Bejarano, M T}},
  issn         = {{0006-4971}},
  keywords     = {{Animals; Burkitt Lymphoma; Cell Division; Cell Line; Endothelial Growth Factors; Endothelium, Vascular; Fibroblast Growth Factor 2; Gene Expression; Interleukin-10; Killer Cells, Natural; Lymphokines; Mice; Mice, SCID; Neoplasm Transplantation; Neovascularization, Pathologic; Rabbits; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{7}},
  pages        = {{73--2568}},
  publisher    = {{American Society of Hematology}},
  series       = {{Blood}},
  title        = {{Abolished angiogenicity and tumorigenicity of Burkitt lymphoma by interleukin-10}},
  volume       = {{96}},
  year         = {{2000}},
}